| Full name: C-C motif chemokine ligand 13 | Alias Symbol: MCP-4|NCC-1|SCYL1|CKb10|MGC17134 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6357 | HGNC ID: HGNC:10611 | Ensembl Gene: ENSG00000181374 | OMIM ID: 601391 |
| Drug and gene relationship at DGIdb | |||
CCL13 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04064 | NF-kappa B signaling pathway |
Expression of CCL13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL13 | 6357 | 206407_s_at | -1.2062 | 0.1704 | |
| GSE20347 | CCL13 | 6357 | 206407_s_at | 0.0553 | 0.5510 | |
| GSE23400 | CCL13 | 6357 | 216714_at | -0.0961 | 0.0285 | |
| GSE26886 | CCL13 | 6357 | 206407_s_at | 0.0587 | 0.8121 | |
| GSE29001 | CCL13 | 6357 | 206407_s_at | 0.1406 | 0.6295 | |
| GSE38129 | CCL13 | 6357 | 206407_s_at | -0.0489 | 0.8135 | |
| GSE45670 | CCL13 | 6357 | 206407_s_at | -0.7218 | 0.0383 | |
| GSE63941 | CCL13 | 6357 | 206407_s_at | -1.6305 | 0.0000 | |
| GSE77861 | CCL13 | 6357 | 206407_s_at | -0.0347 | 0.7998 | |
| GSE97050 | CCL13 | 6357 | A_24_P125335 | 0.2990 | 0.2574 | |
| SRP064894 | CCL13 | 6357 | RNAseq | -0.7773 | 0.0565 | |
| SRP133303 | CCL13 | 6357 | RNAseq | 0.0806 | 0.8336 | |
| SRP159526 | CCL13 | 6357 | RNAseq | 1.2049 | 0.1189 | |
| SRP219564 | CCL13 | 6357 | RNAseq | 1.6007 | 0.0191 | |
| TCGA | CCL13 | 6357 | RNAseq | 0.3485 | 0.4050 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CCL13 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CCL13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL13 | 6357 | 5 | 1 | 24 | |
| GSE20123 | CCL13 | 6357 | 5 | 1 | 24 | |
| GSE43470 | CCL13 | 6357 | 1 | 2 | 40 | |
| GSE46452 | CCL13 | 6357 | 34 | 0 | 25 | |
| GSE47630 | CCL13 | 6357 | 7 | 1 | 32 | |
| GSE54993 | CCL13 | 6357 | 3 | 3 | 64 | |
| GSE54994 | CCL13 | 6357 | 7 | 6 | 40 | |
| GSE60625 | CCL13 | 6357 | 4 | 0 | 7 | |
| GSE74703 | CCL13 | 6357 | 1 | 1 | 34 | |
| GSE74704 | CCL13 | 6357 | 3 | 1 | 16 | |
| TCGA | CCL13 | 6357 | 20 | 9 | 67 |
Total number of gains: 90; Total number of losses: 25; Total Number of normals: 373.
Somatic mutations of CCL13:
Generating mutation plots.
Highly correlated genes for CCL13:
Showing top 20/138 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL13 | RASGRF2 | 0.736172 | 3 | 0 | 3 |
| CCL13 | SHANK1 | 0.717275 | 3 | 0 | 3 |
| CCL13 | TRH | 0.716387 | 3 | 0 | 3 |
| CCL13 | PDZRN3 | 0.710144 | 4 | 0 | 3 |
| CCL13 | ROBO2 | 0.702646 | 3 | 0 | 3 |
| CCL13 | ABCC6 | 0.698995 | 3 | 0 | 3 |
| CCL13 | ADAMTS2 | 0.69889 | 3 | 0 | 3 |
| CCL13 | SCN3A | 0.692273 | 5 | 0 | 4 |
| CCL13 | CCDC170 | 0.68896 | 3 | 0 | 3 |
| CCL13 | SSTR2 | 0.687928 | 3 | 0 | 3 |
| CCL13 | HUS1B | 0.687094 | 3 | 0 | 3 |
| CCL13 | DACH1 | 0.685121 | 3 | 0 | 3 |
| CCL13 | MEP1A | 0.683729 | 4 | 0 | 3 |
| CCL13 | KCNK12 | 0.683003 | 4 | 0 | 3 |
| CCL13 | SLC6A3 | 0.674241 | 3 | 0 | 3 |
| CCL13 | ARHGAP20 | 0.668683 | 3 | 0 | 3 |
| CCL13 | SPACA1 | 0.665035 | 3 | 0 | 3 |
| CCL13 | CLEC1B | 0.664212 | 4 | 0 | 3 |
| CCL13 | GAB2 | 0.663915 | 4 | 0 | 3 |
| CCL13 | ADAMTS19 | 0.663127 | 3 | 0 | 3 |
For details and further investigation, click here
