| Full name: nudix hydrolase 16 like 1 | Alias Symbol: SDOS|TIRR | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 84309 | HGNC ID: HGNC:28154 | Ensembl Gene: ENSG00000168101 | OMIM ID: 617338 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
NUDT16L1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of NUDT16L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUDT16L1 | 84309 | 224477_s_at | 0.0797 | 0.9177 | |
| GSE26886 | NUDT16L1 | 84309 | 224477_s_at | -0.5056 | 0.0044 | |
| GSE45670 | NUDT16L1 | 84309 | 224477_s_at | -0.0554 | 0.6667 | |
| GSE53622 | NUDT16L1 | 84309 | 97523 | -0.0368 | 0.7220 | |
| GSE53624 | NUDT16L1 | 84309 | 97523 | -0.2699 | 0.0000 | |
| GSE63941 | NUDT16L1 | 84309 | 224477_s_at | -0.7353 | 0.0748 | |
| GSE77861 | NUDT16L1 | 84309 | 224477_s_at | -0.0561 | 0.7880 | |
| GSE97050 | NUDT16L1 | 84309 | A_23_P49429 | -0.1406 | 0.5227 | |
| SRP007169 | NUDT16L1 | 84309 | RNAseq | -0.7962 | 0.1398 | |
| SRP008496 | NUDT16L1 | 84309 | RNAseq | -0.7046 | 0.0344 | |
| SRP064894 | NUDT16L1 | 84309 | RNAseq | -0.2033 | 0.5135 | |
| SRP133303 | NUDT16L1 | 84309 | RNAseq | -0.2138 | 0.2357 | |
| SRP159526 | NUDT16L1 | 84309 | RNAseq | 0.0648 | 0.8064 | |
| SRP193095 | NUDT16L1 | 84309 | RNAseq | -0.4637 | 0.0000 | |
| SRP219564 | NUDT16L1 | 84309 | RNAseq | -0.2708 | 0.2068 | |
| TCGA | NUDT16L1 | 84309 | RNAseq | -0.0767 | 0.2213 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NUDT16L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUDT16L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUDT16L1 | 84309 | 5 | 5 | 20 | |
| GSE20123 | NUDT16L1 | 84309 | 5 | 4 | 21 | |
| GSE43470 | NUDT16L1 | 84309 | 4 | 6 | 33 | |
| GSE46452 | NUDT16L1 | 84309 | 38 | 1 | 20 | |
| GSE47630 | NUDT16L1 | 84309 | 13 | 6 | 21 | |
| GSE54993 | NUDT16L1 | 84309 | 3 | 5 | 62 | |
| GSE54994 | NUDT16L1 | 84309 | 5 | 9 | 39 | |
| GSE60625 | NUDT16L1 | 84309 | 4 | 0 | 7 | |
| GSE74703 | NUDT16L1 | 84309 | 4 | 4 | 28 | |
| GSE74704 | NUDT16L1 | 84309 | 3 | 2 | 15 | |
| TCGA | NUDT16L1 | 84309 | 19 | 13 | 64 |
Total number of gains: 103; Total number of losses: 55; Total Number of normals: 330.
Somatic mutations of NUDT16L1:
Generating mutation plots.
Highly correlated genes for NUDT16L1:
Showing top 20/87 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUDT16L1 | GRIPAP1 | 0.782959 | 3 | 0 | 3 |
| NUDT16L1 | ABCB9 | 0.76455 | 3 | 0 | 3 |
| NUDT16L1 | YIPF1 | 0.761824 | 3 | 0 | 3 |
| NUDT16L1 | TRH | 0.759454 | 3 | 0 | 3 |
| NUDT16L1 | TMEM229A | 0.756867 | 3 | 0 | 3 |
| NUDT16L1 | NKX2-8 | 0.753641 | 3 | 0 | 3 |
| NUDT16L1 | CHRNA10 | 0.753236 | 3 | 0 | 3 |
| NUDT16L1 | UGT2B11 | 0.733217 | 3 | 0 | 3 |
| NUDT16L1 | ENTPD8 | 0.724487 | 3 | 0 | 3 |
| NUDT16L1 | DNAJC17 | 0.720057 | 3 | 0 | 3 |
| NUDT16L1 | ZNF205 | 0.717584 | 3 | 0 | 3 |
| NUDT16L1 | CROT | 0.715568 | 3 | 0 | 3 |
| NUDT16L1 | CCDC22 | 0.708921 | 4 | 0 | 4 |
| NUDT16L1 | ING5 | 0.708763 | 3 | 0 | 3 |
| NUDT16L1 | CTSE | 0.707053 | 4 | 0 | 3 |
| NUDT16L1 | TOR2A | 0.695086 | 3 | 0 | 3 |
| NUDT16L1 | RXRB | 0.694364 | 3 | 0 | 3 |
| NUDT16L1 | AKR7A3 | 0.69416 | 4 | 0 | 3 |
| NUDT16L1 | TTC21A | 0.689387 | 4 | 0 | 3 |
| NUDT16L1 | NWD1 | 0.686003 | 3 | 0 | 3 |
For details and further investigation, click here
