| Full name: transient receptor potential cation channel subfamily C member 6 | Alias Symbol: TRP6 | ||
| Type: protein-coding gene | Cytoband: 11q22.1 | ||
| Entrez ID: 7225 | HGNC ID: HGNC:12338 | Ensembl Gene: ENSG00000137672 | OMIM ID: 603652 |
| Drug and gene relationship at DGIdb | |||
TRPC6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04360 | Axon guidance |
Expression of TRPC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPC6 | 7225 | 206528_at | -0.4248 | 0.4960 | |
| GSE20347 | TRPC6 | 7225 | 217287_s_at | 0.0184 | 0.8326 | |
| GSE23400 | TRPC6 | 7225 | 217287_s_at | -0.1594 | 0.0018 | |
| GSE26886 | TRPC6 | 7225 | 217287_s_at | 0.1137 | 0.5302 | |
| GSE29001 | TRPC6 | 7225 | 217287_s_at | -0.1659 | 0.2150 | |
| GSE38129 | TRPC6 | 7225 | 206528_at | -0.1085 | 0.5666 | |
| GSE45670 | TRPC6 | 7225 | 206528_at | -0.6300 | 0.0135 | |
| GSE63941 | TRPC6 | 7225 | 217287_s_at | -3.6539 | 0.0000 | |
| GSE77861 | TRPC6 | 7225 | 217287_s_at | 0.0769 | 0.4948 | |
| GSE97050 | TRPC6 | 7225 | A_33_P3337627 | -0.1368 | 0.7663 | |
| SRP007169 | TRPC6 | 7225 | RNAseq | 1.9048 | 0.0051 | |
| SRP064894 | TRPC6 | 7225 | RNAseq | -0.5336 | 0.0550 | |
| SRP133303 | TRPC6 | 7225 | RNAseq | -0.6501 | 0.0149 | |
| SRP159526 | TRPC6 | 7225 | RNAseq | -0.7864 | 0.1656 | |
| SRP193095 | TRPC6 | 7225 | RNAseq | 0.8047 | 0.0001 | |
| SRP219564 | TRPC6 | 7225 | RNAseq | -1.7622 | 0.0154 | |
| TCGA | TRPC6 | 7225 | RNAseq | -0.3082 | 0.0594 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by TRPC6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TRPC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPC6 | 7225 | 4 | 9 | 17 | |
| GSE20123 | TRPC6 | 7225 | 4 | 9 | 17 | |
| GSE43470 | TRPC6 | 7225 | 5 | 5 | 33 | |
| GSE46452 | TRPC6 | 7225 | 5 | 24 | 30 | |
| GSE47630 | TRPC6 | 7225 | 2 | 19 | 19 | |
| GSE54993 | TRPC6 | 7225 | 8 | 4 | 58 | |
| GSE54994 | TRPC6 | 7225 | 7 | 18 | 28 | |
| GSE60625 | TRPC6 | 7225 | 0 | 3 | 8 | |
| GSE74703 | TRPC6 | 7225 | 3 | 4 | 29 | |
| GSE74704 | TRPC6 | 7225 | 4 | 5 | 11 | |
| TCGA | TRPC6 | 7225 | 10 | 44 | 42 |
Total number of gains: 52; Total number of losses: 144; Total Number of normals: 292.
Somatic mutations of TRPC6:
Generating mutation plots.
Highly correlated genes for TRPC6:
Showing top 20/653 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPC6 | DNM3OS | 0.801212 | 3 | 0 | 3 |
| TRPC6 | DSTYK | 0.763381 | 3 | 0 | 3 |
| TRPC6 | PABPC5 | 0.763216 | 3 | 0 | 3 |
| TRPC6 | IGIP | 0.757935 | 3 | 0 | 3 |
| TRPC6 | ROR1 | 0.751827 | 3 | 0 | 3 |
| TRPC6 | CLMP | 0.744953 | 5 | 0 | 5 |
| TRPC6 | KDSR | 0.741887 | 3 | 0 | 3 |
| TRPC6 | MAGI2-AS3 | 0.73814 | 3 | 0 | 3 |
| TRPC6 | GALNT15 | 0.735044 | 4 | 0 | 4 |
| TRPC6 | PRICKLE2 | 0.733152 | 4 | 0 | 4 |
| TRPC6 | TMEM150A | 0.731814 | 3 | 0 | 3 |
| TRPC6 | DSEL | 0.730247 | 4 | 0 | 4 |
| TRPC6 | LIX1L | 0.718677 | 4 | 0 | 4 |
| TRPC6 | SLC9A9 | 0.716633 | 3 | 0 | 3 |
| TRPC6 | NFIX | 0.716191 | 3 | 0 | 3 |
| TRPC6 | MASP1 | 0.715813 | 3 | 0 | 3 |
| TRPC6 | AHRR | 0.713055 | 3 | 0 | 3 |
| TRPC6 | RSPH9 | 0.702343 | 3 | 0 | 3 |
| TRPC6 | MICU3 | 0.701689 | 3 | 0 | 3 |
| TRPC6 | CNRIP1 | 0.697136 | 5 | 0 | 4 |
For details and further investigation, click here
