| Full name: 3-ketodihydrosphingosine reductase | Alias Symbol: DHSR|SDR35C1 | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 2531 | HGNC ID: HGNC:4021 | Ensembl Gene: ENSG00000119537 | OMIM ID: 136440 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KDSR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDSR | 2531 | 202419_at | 0.2347 | 0.6244 | |
| GSE20347 | KDSR | 2531 | 202419_at | 0.0038 | 0.9802 | |
| GSE23400 | KDSR | 2531 | 202419_at | 0.2350 | 0.0042 | |
| GSE26886 | KDSR | 2531 | 202419_at | -0.1264 | 0.5191 | |
| GSE29001 | KDSR | 2531 | 202419_at | 0.0615 | 0.7863 | |
| GSE38129 | KDSR | 2531 | 202419_at | 0.0432 | 0.8481 | |
| GSE45670 | KDSR | 2531 | 202419_at | -0.0508 | 0.7806 | |
| GSE53622 | KDSR | 2531 | 36520 | -0.2609 | 0.0008 | |
| GSE53624 | KDSR | 2531 | 36520 | -0.1955 | 0.0063 | |
| GSE63941 | KDSR | 2531 | 202419_at | -2.3638 | 0.0001 | |
| GSE77861 | KDSR | 2531 | 202419_at | 0.4364 | 0.0626 | |
| GSE97050 | KDSR | 2531 | A_32_P515088 | -0.4960 | 0.1057 | |
| SRP007169 | KDSR | 2531 | RNAseq | -0.4620 | 0.1936 | |
| SRP008496 | KDSR | 2531 | RNAseq | -0.1024 | 0.7068 | |
| SRP064894 | KDSR | 2531 | RNAseq | 0.0343 | 0.7895 | |
| SRP133303 | KDSR | 2531 | RNAseq | 0.0511 | 0.7024 | |
| SRP159526 | KDSR | 2531 | RNAseq | -0.1346 | 0.6116 | |
| SRP193095 | KDSR | 2531 | RNAseq | 0.1149 | 0.3871 | |
| SRP219564 | KDSR | 2531 | RNAseq | -0.4372 | 0.1109 | |
| TCGA | KDSR | 2531 | RNAseq | 0.0478 | 0.3100 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KDSR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KDSR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDSR | 2531 | 1 | 9 | 20 | |
| GSE20123 | KDSR | 2531 | 1 | 9 | 20 | |
| GSE43470 | KDSR | 2531 | 0 | 7 | 36 | |
| GSE46452 | KDSR | 2531 | 1 | 26 | 32 | |
| GSE47630 | KDSR | 2531 | 5 | 21 | 14 | |
| GSE54993 | KDSR | 2531 | 9 | 0 | 61 | |
| GSE54994 | KDSR | 2531 | 1 | 18 | 34 | |
| GSE60625 | KDSR | 2531 | 0 | 4 | 7 | |
| GSE74703 | KDSR | 2531 | 0 | 7 | 29 | |
| GSE74704 | KDSR | 2531 | 1 | 6 | 13 | |
| TCGA | KDSR | 2531 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of KDSR:
Generating mutation plots.
Highly correlated genes for KDSR:
Showing top 20/522 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDSR | C18orf54 | 0.806699 | 3 | 0 | 3 |
| KDSR | TTC26 | 0.780949 | 3 | 0 | 3 |
| KDSR | DCHS1 | 0.780489 | 3 | 0 | 3 |
| KDSR | SYNC | 0.777979 | 3 | 0 | 3 |
| KDSR | PDGFRB | 0.776653 | 3 | 0 | 3 |
| KDSR | ANGPTL2 | 0.76931 | 3 | 0 | 3 |
| KDSR | DTYMK | 0.766638 | 3 | 0 | 3 |
| KDSR | POLR2G | 0.75557 | 3 | 0 | 3 |
| KDSR | SMPD1 | 0.753766 | 3 | 0 | 3 |
| KDSR | IWS1 | 0.752575 | 3 | 0 | 3 |
| KDSR | LRP6 | 0.748001 | 3 | 0 | 3 |
| KDSR | EFEMP2 | 0.747939 | 3 | 0 | 3 |
| KDSR | RNF121 | 0.746513 | 3 | 0 | 3 |
| KDSR | PDCD7 | 0.746362 | 3 | 0 | 3 |
| KDSR | TTC8 | 0.744446 | 3 | 0 | 3 |
| KDSR | FOXN3 | 0.743558 | 3 | 0 | 3 |
| KDSR | USP12 | 0.742229 | 5 | 0 | 5 |
| KDSR | TRPC6 | 0.741887 | 3 | 0 | 3 |
| KDSR | ZBTB2 | 0.740828 | 3 | 0 | 3 |
| KDSR | PPIL4 | 0.740424 | 3 | 0 | 3 |
For details and further investigation, click here
