| Full name: dual serine/threonine and tyrosine protein kinase | Alias Symbol: KIAA0472|DustyPK|RIP5 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 25778 | HGNC ID: HGNC:29043 | Ensembl Gene: ENSG00000133059 | OMIM ID: 612666 |
| Drug and gene relationship at DGIdb | |||
Expression of DSTYK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSTYK | 25778 | 214663_at | 0.0413 | 0.9348 | |
| GSE20347 | DSTYK | 25778 | 214663_at | -0.1104 | 0.4200 | |
| GSE23400 | DSTYK | 25778 | 214663_at | -0.0688 | 0.1803 | |
| GSE26886 | DSTYK | 25778 | 214663_at | -0.2353 | 0.5201 | |
| GSE29001 | DSTYK | 25778 | 214663_at | -0.3066 | 0.1811 | |
| GSE38129 | DSTYK | 25778 | 214663_at | -0.1639 | 0.1726 | |
| GSE45670 | DSTYK | 25778 | 214663_at | -0.2422 | 0.0264 | |
| GSE53622 | DSTYK | 25778 | 22423 | -0.1002 | 0.1276 | |
| GSE53624 | DSTYK | 25778 | 22423 | -0.0976 | 0.2797 | |
| GSE63941 | DSTYK | 25778 | 214663_at | -1.8308 | 0.0012 | |
| GSE77861 | DSTYK | 25778 | 229017_s_at | 0.1750 | 0.2622 | |
| GSE97050 | DSTYK | 25778 | A_32_P71943 | -0.0928 | 0.7732 | |
| SRP007169 | DSTYK | 25778 | RNAseq | -1.1037 | 0.0015 | |
| SRP008496 | DSTYK | 25778 | RNAseq | -0.5846 | 0.0135 | |
| SRP064894 | DSTYK | 25778 | RNAseq | -0.3715 | 0.0262 | |
| SRP133303 | DSTYK | 25778 | RNAseq | -0.0918 | 0.5994 | |
| SRP159526 | DSTYK | 25778 | RNAseq | 0.0279 | 0.9218 | |
| SRP193095 | DSTYK | 25778 | RNAseq | -0.0720 | 0.5250 | |
| SRP219564 | DSTYK | 25778 | RNAseq | -0.1642 | 0.5032 | |
| TCGA | DSTYK | 25778 | RNAseq | 0.0036 | 0.9439 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DSTYK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSTYK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSTYK | 25778 | 11 | 0 | 19 | |
| GSE20123 | DSTYK | 25778 | 11 | 0 | 19 | |
| GSE43470 | DSTYK | 25778 | 6 | 0 | 37 | |
| GSE46452 | DSTYK | 25778 | 3 | 1 | 55 | |
| GSE47630 | DSTYK | 25778 | 14 | 0 | 26 | |
| GSE54993 | DSTYK | 25778 | 0 | 6 | 64 | |
| GSE54994 | DSTYK | 25778 | 15 | 0 | 38 | |
| GSE60625 | DSTYK | 25778 | 0 | 0 | 11 | |
| GSE74703 | DSTYK | 25778 | 6 | 0 | 30 | |
| GSE74704 | DSTYK | 25778 | 5 | 0 | 15 | |
| TCGA | DSTYK | 25778 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of DSTYK:
Generating mutation plots.
Highly correlated genes for DSTYK:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSTYK | RAB11FIP5 | 0.764078 | 3 | 0 | 3 |
| DSTYK | TRPC6 | 0.763381 | 3 | 0 | 3 |
| DSTYK | SLC9A6 | 0.748314 | 3 | 0 | 3 |
| DSTYK | ARHGAP17 | 0.746092 | 3 | 0 | 3 |
| DSTYK | SHC1 | 0.739277 | 3 | 0 | 3 |
| DSTYK | RNF4 | 0.732455 | 3 | 0 | 3 |
| DSTYK | WTIP | 0.730798 | 3 | 0 | 3 |
| DSTYK | SNX18 | 0.729323 | 3 | 0 | 3 |
| DSTYK | PIGP | 0.724818 | 3 | 0 | 3 |
| DSTYK | TRIP11 | 0.714906 | 3 | 0 | 3 |
| DSTYK | GNG12 | 0.711102 | 3 | 0 | 3 |
| DSTYK | YTHDF3 | 0.710013 | 3 | 0 | 3 |
| DSTYK | SLC39A13 | 0.709205 | 3 | 0 | 3 |
| DSTYK | ISCA2 | 0.708935 | 3 | 0 | 3 |
| DSTYK | ZNF550 | 0.708875 | 3 | 0 | 3 |
| DSTYK | KCTD21 | 0.708443 | 3 | 0 | 3 |
| DSTYK | SUN1 | 0.706227 | 3 | 0 | 3 |
| DSTYK | CTR9 | 0.704907 | 4 | 0 | 3 |
| DSTYK | RGL1 | 0.703429 | 3 | 0 | 3 |
| DSTYK | RNF14 | 0.701942 | 3 | 0 | 3 |
For details and further investigation, click here
