| Full name: receptor tyrosine kinase like orphan receptor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 4919 | HGNC ID: HGNC:10256 | Ensembl Gene: ENSG00000185483 | OMIM ID: 602336 |
| Drug and gene relationship at DGIdb | |||
Expression of ROR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROR1 | 4919 | 205805_s_at | -1.7267 | 0.0222 | |
| GSE20347 | ROR1 | 4919 | 205805_s_at | -0.8386 | 0.0000 | |
| GSE23400 | ROR1 | 4919 | 211057_at | -0.2010 | 0.0000 | |
| GSE26886 | ROR1 | 4919 | 205805_s_at | -0.1565 | 0.6499 | |
| GSE29001 | ROR1 | 4919 | 205805_s_at | -1.3072 | 0.0003 | |
| GSE38129 | ROR1 | 4919 | 205805_s_at | -1.0774 | 0.0000 | |
| GSE45670 | ROR1 | 4919 | 232060_at | -2.7955 | 0.0000 | |
| GSE53622 | ROR1 | 4919 | 58726 | -2.4260 | 0.0000 | |
| GSE53624 | ROR1 | 4919 | 58726 | -2.5200 | 0.0000 | |
| GSE63941 | ROR1 | 4919 | 205805_s_at | -2.2143 | 0.0053 | |
| GSE77861 | ROR1 | 4919 | 211057_at | -0.1594 | 0.1722 | |
| GSE97050 | ROR1 | 4919 | A_23_P12363 | -0.5921 | 0.1678 | |
| SRP007169 | ROR1 | 4919 | RNAseq | -2.7774 | 0.0000 | |
| SRP008496 | ROR1 | 4919 | RNAseq | -2.4804 | 0.0000 | |
| SRP064894 | ROR1 | 4919 | RNAseq | -1.5185 | 0.0003 | |
| SRP133303 | ROR1 | 4919 | RNAseq | -1.7599 | 0.0000 | |
| SRP159526 | ROR1 | 4919 | RNAseq | -1.9157 | 0.0007 | |
| SRP193095 | ROR1 | 4919 | RNAseq | -1.4874 | 0.0000 | |
| SRP219564 | ROR1 | 4919 | RNAseq | -0.9261 | 0.0790 | |
| TCGA | ROR1 | 4919 | RNAseq | -1.2741 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by ROR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROR1 | 4919 | 3 | 7 | 20 | |
| GSE20123 | ROR1 | 4919 | 3 | 6 | 21 | |
| GSE43470 | ROR1 | 4919 | 5 | 4 | 34 | |
| GSE46452 | ROR1 | 4919 | 1 | 1 | 57 | |
| GSE47630 | ROR1 | 4919 | 8 | 5 | 27 | |
| GSE54993 | ROR1 | 4919 | 0 | 0 | 70 | |
| GSE54994 | ROR1 | 4919 | 6 | 5 | 42 | |
| GSE60625 | ROR1 | 4919 | 0 | 0 | 11 | |
| GSE74703 | ROR1 | 4919 | 4 | 3 | 29 | |
| GSE74704 | ROR1 | 4919 | 2 | 3 | 15 | |
| TCGA | ROR1 | 4919 | 11 | 21 | 64 |
Total number of gains: 43; Total number of losses: 55; Total Number of normals: 390.
Somatic mutations of ROR1:
Generating mutation plots.
Highly correlated genes for ROR1:
Showing top 20/1498 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROR1 | LYRM7 | 0.829448 | 3 | 0 | 3 |
| ROR1 | LINC01082 | 0.78702 | 5 | 0 | 5 |
| ROR1 | CLEC3B | 0.774308 | 3 | 0 | 3 |
| ROR1 | SPATA18 | 0.764221 | 5 | 0 | 5 |
| ROR1 | LRRK2 | 0.755848 | 6 | 0 | 6 |
| ROR1 | RNF185 | 0.755596 | 3 | 0 | 3 |
| ROR1 | CYYR1 | 0.754929 | 5 | 0 | 5 |
| ROR1 | FBXO8 | 0.754263 | 5 | 0 | 5 |
| ROR1 | C1QTNF7 | 0.752165 | 5 | 0 | 5 |
| ROR1 | TRPC6 | 0.751827 | 3 | 0 | 3 |
| ROR1 | CCL14 | 0.746239 | 3 | 0 | 3 |
| ROR1 | ARF5 | 0.7457 | 3 | 0 | 3 |
| ROR1 | LIFR | 0.743955 | 5 | 0 | 5 |
| ROR1 | MFAP4 | 0.742313 | 6 | 0 | 6 |
| ROR1 | CA13 | 0.740494 | 3 | 0 | 3 |
| ROR1 | ANGPTL1 | 0.73852 | 6 | 0 | 6 |
| ROR1 | ASPA | 0.735188 | 10 | 0 | 9 |
| ROR1 | CYP21A2 | 0.734861 | 3 | 0 | 3 |
| ROR1 | PAQR8 | 0.733916 | 6 | 0 | 5 |
| ROR1 | ZNF425 | 0.727571 | 4 | 0 | 4 |
For details and further investigation, click here
