| Full name: transient receptor potential cation channel subfamily M member 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 79054 | HGNC ID: HGNC:17961 | Ensembl Gene: ENSG00000144481 | OMIM ID: 606678 |
| Drug and gene relationship at DGIdb | |||
TRPM8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of TRPM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPM8 | 79054 | 220226_at | -0.1346 | 0.6398 | |
| GSE20347 | TRPM8 | 79054 | 220226_at | -0.0495 | 0.5296 | |
| GSE23400 | TRPM8 | 79054 | 220226_at | -0.0370 | 0.2067 | |
| GSE26886 | TRPM8 | 79054 | 220226_at | 0.2511 | 0.0520 | |
| GSE29001 | TRPM8 | 79054 | 220226_at | -0.2509 | 0.0416 | |
| GSE38129 | TRPM8 | 79054 | 220226_at | -0.1581 | 0.0051 | |
| GSE45670 | TRPM8 | 79054 | 220226_at | -0.1268 | 0.1524 | |
| GSE53622 | TRPM8 | 79054 | 98107 | 0.0679 | 0.4060 | |
| GSE53624 | TRPM8 | 79054 | 98107 | 0.0048 | 0.9642 | |
| GSE63941 | TRPM8 | 79054 | 220226_at | 0.1699 | 0.2083 | |
| GSE77861 | TRPM8 | 79054 | 220226_at | -0.1617 | 0.2927 | |
| GSE97050 | TRPM8 | 79054 | A_33_P3317327 | 0.0339 | 0.8925 | |
| SRP133303 | TRPM8 | 79054 | RNAseq | 0.1635 | 0.4093 | |
| TCGA | TRPM8 | 79054 | RNAseq | 1.9700 | 0.0180 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TRPM8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPM8 | 79054 | 1 | 11 | 18 | |
| GSE20123 | TRPM8 | 79054 | 1 | 11 | 18 | |
| GSE43470 | TRPM8 | 79054 | 1 | 9 | 33 | |
| GSE46452 | TRPM8 | 79054 | 0 | 5 | 54 | |
| GSE47630 | TRPM8 | 79054 | 4 | 5 | 31 | |
| GSE54993 | TRPM8 | 79054 | 3 | 2 | 65 | |
| GSE54994 | TRPM8 | 79054 | 6 | 10 | 37 | |
| GSE60625 | TRPM8 | 79054 | 0 | 3 | 8 | |
| GSE74703 | TRPM8 | 79054 | 1 | 7 | 28 | |
| GSE74704 | TRPM8 | 79054 | 1 | 5 | 14 | |
| TCGA | TRPM8 | 79054 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 97; Total Number of normals: 362.
Somatic mutations of TRPM8:
Generating mutation plots.
Highly correlated genes for TRPM8:
Showing top 20/570 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPM8 | PRSS38 | 0.882762 | 3 | 0 | 3 |
| TRPM8 | DCDC1 | 0.840019 | 3 | 0 | 3 |
| TRPM8 | OR2T27 | 0.836921 | 3 | 0 | 3 |
| TRPM8 | YY2 | 0.827574 | 3 | 0 | 3 |
| TRPM8 | SLC22A25 | 0.815395 | 3 | 0 | 3 |
| TRPM8 | C1QL2 | 0.81482 | 3 | 0 | 3 |
| TRPM8 | PAX6 | 0.811303 | 3 | 0 | 3 |
| TRPM8 | TTLL9 | 0.809816 | 3 | 0 | 3 |
| TRPM8 | NKX6-3 | 0.80956 | 3 | 0 | 3 |
| TRPM8 | GRXCR2 | 0.808517 | 3 | 0 | 3 |
| TRPM8 | OR2T1 | 0.80534 | 3 | 0 | 3 |
| TRPM8 | PLA2G2C | 0.80406 | 3 | 0 | 3 |
| TRPM8 | FOXE3 | 0.80134 | 3 | 0 | 3 |
| TRPM8 | TULP2 | 0.795548 | 3 | 0 | 3 |
| TRPM8 | TTC12 | 0.793305 | 3 | 0 | 3 |
| TRPM8 | OR5A1 | 0.788153 | 3 | 0 | 3 |
| TRPM8 | BBC3 | 0.786717 | 3 | 0 | 3 |
| TRPM8 | STRC | 0.779554 | 3 | 0 | 3 |
| TRPM8 | OR2A5 | 0.77951 | 3 | 0 | 3 |
| TRPM8 | BSX | 0.7735 | 3 | 0 | 3 |
For details and further investigation, click here
