| Full name: thyroid stimulating hormone subunit beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 7252 | HGNC ID: HGNC:12372 | Ensembl Gene: ENSG00000134200 | OMIM ID: 188540 |
| Drug and gene relationship at DGIdb | |||
TSHB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04918 | Thyroid hormone synthesis | |
| hsa04923 | Regulation of lipolysis in adipocytes |
Expression of TSHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSHB | 7252 | 214529_at | -0.1686 | 0.3659 | |
| GSE20347 | TSHB | 7252 | 214529_at | -0.0943 | 0.1988 | |
| GSE23400 | TSHB | 7252 | 214529_at | -0.1542 | 0.0001 | |
| GSE26886 | TSHB | 7252 | 214529_at | -0.2123 | 0.0237 | |
| GSE29001 | TSHB | 7252 | 214529_at | -0.3363 | 0.0187 | |
| GSE38129 | TSHB | 7252 | 214529_at | -0.1762 | 0.0313 | |
| GSE45670 | TSHB | 7252 | 214529_at | -0.1730 | 0.0525 | |
| GSE53622 | TSHB | 7252 | 73761 | -0.2342 | 0.0176 | |
| GSE53624 | TSHB | 7252 | 73761 | -0.6049 | 0.0000 | |
| GSE63941 | TSHB | 7252 | 214529_at | -1.4251 | 0.0001 | |
| GSE77861 | TSHB | 7252 | 214529_at | -0.2033 | 0.0422 | |
| GSE97050 | TSHB | 7252 | A_23_P12128 | 0.0604 | 0.8352 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TSHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSHB | 7252 | 0 | 9 | 21 | |
| GSE20123 | TSHB | 7252 | 0 | 9 | 21 | |
| GSE43470 | TSHB | 7252 | 0 | 8 | 35 | |
| GSE46452 | TSHB | 7252 | 2 | 1 | 56 | |
| GSE47630 | TSHB | 7252 | 9 | 5 | 26 | |
| GSE54993 | TSHB | 7252 | 0 | 1 | 69 | |
| GSE54994 | TSHB | 7252 | 7 | 3 | 43 | |
| GSE60625 | TSHB | 7252 | 0 | 0 | 11 | |
| GSE74703 | TSHB | 7252 | 0 | 7 | 29 | |
| GSE74704 | TSHB | 7252 | 0 | 5 | 15 | |
| TCGA | TSHB | 7252 | 12 | 29 | 55 |
Total number of gains: 30; Total number of losses: 77; Total Number of normals: 381.
Somatic mutations of TSHB:
Generating mutation plots.
Highly correlated genes for TSHB:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSHB | GPHB5 | 0.841739 | 3 | 0 | 3 |
| TSHB | KRTAP10-8 | 0.767929 | 3 | 0 | 3 |
| TSHB | PATE3 | 0.761169 | 3 | 0 | 3 |
| TSHB | AQP4 | 0.748384 | 3 | 0 | 3 |
| TSHB | SYPL2 | 0.743329 | 3 | 0 | 3 |
| TSHB | KRTAP9-1 | 0.738326 | 3 | 0 | 3 |
| TSHB | KRTAP5-5 | 0.727515 | 3 | 0 | 3 |
| TSHB | TAAR2 | 0.724165 | 4 | 0 | 4 |
| TSHB | CHRM2 | 0.717273 | 5 | 0 | 5 |
| TSHB | KIR2DS2 | 0.715694 | 4 | 0 | 4 |
| TSHB | JAZF1-AS1 | 0.715579 | 3 | 0 | 3 |
| TSHB | SLC45A2 | 0.711646 | 4 | 0 | 4 |
| TSHB | COL20A1 | 0.711281 | 3 | 0 | 3 |
| TSHB | KRTAP5-4 | 0.70878 | 3 | 0 | 3 |
| TSHB | SLC5A7 | 0.706319 | 4 | 0 | 4 |
| TSHB | FGF14 | 0.701623 | 4 | 0 | 4 |
| TSHB | NUDT7 | 0.69414 | 3 | 0 | 3 |
| TSHB | BARHL2 | 0.693771 | 3 | 0 | 3 |
| TSHB | ZNF280A | 0.693759 | 6 | 0 | 6 |
| TSHB | OR2J2 | 0.689309 | 4 | 0 | 4 |
For details and further investigation, click here
