| Full name: thioredoxin 2 | Alias Symbol: MT-TRX | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 25828 | HGNC ID: HGNC:17772 | Ensembl Gene: ENSG00000100348 | OMIM ID: 609063 |
| Drug and gene relationship at DGIdb | |||
Expression of TXN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXN2 | 25828 | 209077_at | -0.1440 | 0.5057 | |
| GSE20347 | TXN2 | 25828 | 209077_at | -0.3026 | 0.0033 | |
| GSE23400 | TXN2 | 25828 | 209077_at | -0.1953 | 0.0000 | |
| GSE26886 | TXN2 | 25828 | 209077_at | 0.3394 | 0.0092 | |
| GSE29001 | TXN2 | 25828 | 209077_at | -0.3124 | 0.0717 | |
| GSE38129 | TXN2 | 25828 | 209077_at | -0.2747 | 0.0026 | |
| GSE45670 | TXN2 | 25828 | 209077_at | -0.0165 | 0.9044 | |
| GSE53622 | TXN2 | 25828 | 28495 | -0.1129 | 0.0712 | |
| GSE53624 | TXN2 | 25828 | 31418 | -0.2416 | 0.0003 | |
| GSE63941 | TXN2 | 25828 | 209078_s_at | 0.5895 | 0.0978 | |
| GSE77861 | TXN2 | 25828 | 209077_at | -0.1672 | 0.4647 | |
| GSE97050 | TXN2 | 25828 | A_23_P68899 | -0.2259 | 0.3144 | |
| SRP007169 | TXN2 | 25828 | RNAseq | -0.6137 | 0.0787 | |
| SRP008496 | TXN2 | 25828 | RNAseq | -0.9049 | 0.0000 | |
| SRP064894 | TXN2 | 25828 | RNAseq | 0.0919 | 0.7343 | |
| SRP133303 | TXN2 | 25828 | RNAseq | -0.2085 | 0.1828 | |
| SRP159526 | TXN2 | 25828 | RNAseq | -0.1360 | 0.5829 | |
| SRP193095 | TXN2 | 25828 | RNAseq | -0.5233 | 0.0002 | |
| SRP219564 | TXN2 | 25828 | RNAseq | 0.0128 | 0.9635 | |
| TCGA | TXN2 | 25828 | RNAseq | -0.0512 | 0.2866 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TXN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXN2 | 25828 | 6 | 6 | 18 | |
| GSE20123 | TXN2 | 25828 | 6 | 5 | 19 | |
| GSE43470 | TXN2 | 25828 | 4 | 6 | 33 | |
| GSE46452 | TXN2 | 25828 | 31 | 1 | 27 | |
| GSE47630 | TXN2 | 25828 | 8 | 5 | 27 | |
| GSE54993 | TXN2 | 25828 | 3 | 6 | 61 | |
| GSE54994 | TXN2 | 25828 | 9 | 9 | 35 | |
| GSE60625 | TXN2 | 25828 | 5 | 0 | 6 | |
| GSE74703 | TXN2 | 25828 | 4 | 4 | 28 | |
| GSE74704 | TXN2 | 25828 | 3 | 2 | 15 | |
| TCGA | TXN2 | 25828 | 27 | 15 | 54 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of TXN2:
Generating mutation plots.
Highly correlated genes for TXN2:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXN2 | SLC6A18 | 0.699051 | 3 | 0 | 3 |
| TXN2 | MYO1A | 0.692617 | 3 | 0 | 3 |
| TXN2 | C6orf226 | 0.671523 | 3 | 0 | 3 |
| TXN2 | TRIM31 | 0.662635 | 3 | 0 | 3 |
| TXN2 | MC5R | 0.658048 | 3 | 0 | 3 |
| TXN2 | MAGIX | 0.655572 | 3 | 0 | 3 |
| TXN2 | ADCY8 | 0.654972 | 3 | 0 | 3 |
| TXN2 | CCL16 | 0.650655 | 3 | 0 | 3 |
| TXN2 | ASMTL | 0.648744 | 3 | 0 | 3 |
| TXN2 | C19orf73 | 0.64344 | 3 | 0 | 3 |
| TXN2 | FERD3L | 0.642967 | 3 | 0 | 3 |
| TXN2 | PPP2R5D | 0.638725 | 3 | 0 | 3 |
| TXN2 | ALDH1L1 | 0.638689 | 4 | 0 | 3 |
| TXN2 | EPHA1-AS1 | 0.634604 | 3 | 0 | 3 |
| TXN2 | GNL1 | 0.62892 | 3 | 0 | 3 |
| TXN2 | SMCP | 0.626846 | 3 | 0 | 3 |
| TXN2 | BSND | 0.623867 | 3 | 0 | 3 |
| TXN2 | USH1C | 0.622589 | 3 | 0 | 3 |
| TXN2 | ZNF221 | 0.621067 | 3 | 0 | 3 |
| TXN2 | GPR78 | 0.615481 | 4 | 0 | 3 |
For details and further investigation, click here
