Full name: adenylate cyclase 8	Alias Symbol: HBAC1|AC8
Type: protein-coding gene	Cytoband: 8q24.22
Entrez ID: 114	HGNC ID: HGNC:239	Ensembl Gene: ENSG00000155897	OMIM ID: 103070
Drug and gene relationship at DGIdb

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ADCY8 involved pathways:

KEGG pathway	Description	View
hsa04015	Rap1 signaling pathway	View
hsa04020	Calcium signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04213	Longevity regulating pathway - multiple species	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04270	Vascular smooth muscle contraction	View
hsa04540	Gap junction	View
hsa04611	Platelet activation	View
hsa04713	Circadian entrainment	View
hsa04720	Long-term potentiation	View
hsa04723	Retrograde endocannabinoid signaling	View
hsa04724	Glutamatergic synapse	View
hsa04725	Cholinergic synapse	View
hsa04727	GABAergic synapse	View
hsa04742	Taste transduction	View
hsa04750	Inflammatory mediator regulation of TRP channels	View
hsa04911	Insulin secretion	View
hsa04912	GnRH signaling pathway	View
hsa04913	Ovarian steroidogenesis	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04916	Melanogenesis	View
hsa04918	Thyroid hormone synthesis	View
hsa04921	Oxytocin signaling pathway	View
hsa04923	Regulation of lipolysis in adipocytes	View
hsa04925	Aldosterone synthesis and secretion	View
hsa04970	Salivary secretion	View
hsa04971	Gastric acid secretion	View
hsa04972	Pancreatic secretion	View
hsa04976	Bile secretion	View
hsa05032	Morphine addiction	View
hsa05166	HTLV-I infection	View

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Expression of ADCY8:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ADCY8	114	206811_at	-0.1525	0.6137	Show
GSE20347	ADCY8	114	206811_at	-0.1154	0.1186	Show
GSE23400	ADCY8	114	206811_at	-0.0722	0.0154	Show
GSE26886	ADCY8	114	206811_at	0.5661	0.0001	Show
GSE29001	ADCY8	114	206811_at	-0.0669	0.5242	Show
GSE38129	ADCY8	114	206811_at	-0.1493	0.0307	Show
GSE45670	ADCY8	114	206811_at	0.0884	0.4224	Show
GSE53622	ADCY8	114	39749	-0.0753	0.7077	Show
GSE53624	ADCY8	114	39749	-0.2335	0.0971	Show
GSE63941	ADCY8	114	206811_at	-0.1270	0.5634	Show
GSE77861	ADCY8	114	206811_at	-0.0492	0.8553	Show
TCGA	ADCY8	114	RNAseq	1.0311	0.5196	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by ADCY8 expression:

 

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Copy number change of ADCY8:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ADCY8	114	18	0	12	Show
GSE20123	ADCY8	114	18	0	12	Show
GSE43470	ADCY8	114	21	2	20	Show
GSE46452	ADCY8	114	27	0	32	Show
GSE47630	ADCY8	114	24	0	16	Show
GSE54993	ADCY8	114	0	24	46	Show
GSE54994	ADCY8	114	39	1	13	Show
GSE60625	ADCY8	114	0	7	4	Show
GSE74703	ADCY8	114	18	2	16	Show
GSE74704	ADCY8	114	12	0	8	Show
TCGA	ADCY8	114	68	2	26	Show

Total number of gains: 245; Total number of losses: 38; Total Number of normals: 205.  Download Data

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Somatic mutations of ADCY8:

 

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Highly correlated genes for ADCY8:

 

Showing top 20/358 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ADCY8	LINC00598	0.739569	3	0	3
ADCY8	RADIL	0.713281	3	0	3
ADCY8	TRIM54	0.675079	3	0	3
ADCY8	SOCS3	0.673041	3	0	3
ADCY8	SSTR4	0.66956	4	0	4
ADCY8	LINC00475	0.669495	3	0	3
ADCY8	CRYBA1	0.667755	3	0	3
ADCY8	ADAMTS10	0.662487	3	0	3
ADCY8	TXN2	0.654972	3	0	3
ADCY8	C9orf16	0.651219	3	0	3
ADCY8	CCDC154	0.650753	3	0	3
ADCY8	SMCO3	0.650248	3	0	3
ADCY8	JSRP1	0.648986	4	0	4
ADCY8	C3orf20	0.648767	3	0	3
ADCY8	MAMLD1	0.648629	3	0	3
ADCY8	REG3A	0.642523	4	0	3
ADCY8	MGAT5B	0.641715	3	0	3
ADCY8	ZNF646	0.635219	4	0	3
ADCY8	FNDC8	0.63337	6	0	5
ADCY8	PLA2G3	0.632861	3	0	3

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