| Full name: aldehyde dehydrogenase 1 family member L1 | Alias Symbol: 10-fTHF|FDH | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 10840 | HGNC ID: HGNC:3978 | Ensembl Gene: ENSG00000144908 | OMIM ID: 600249 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH1L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH1L1 | 10840 | 205208_at | -0.4640 | 0.3542 | |
| GSE20347 | ALDH1L1 | 10840 | 205208_at | -0.0601 | 0.8071 | |
| GSE23400 | ALDH1L1 | 10840 | 215798_at | -0.1729 | 0.0003 | |
| GSE26886 | ALDH1L1 | 10840 | 205208_at | -0.2526 | 0.3715 | |
| GSE29001 | ALDH1L1 | 10840 | 205208_at | -0.2374 | 0.1654 | |
| GSE38129 | ALDH1L1 | 10840 | 205208_at | -0.3564 | 0.0518 | |
| GSE45670 | ALDH1L1 | 10840 | 205208_at | -0.0886 | 0.7414 | |
| GSE53622 | ALDH1L1 | 10840 | 64163 | -0.9719 | 0.0000 | |
| GSE53624 | ALDH1L1 | 10840 | 64163 | -1.0873 | 0.0000 | |
| GSE63941 | ALDH1L1 | 10840 | 205208_at | 0.6670 | 0.2444 | |
| GSE77861 | ALDH1L1 | 10840 | 215798_at | -0.1416 | 0.1903 | |
| GSE97050 | ALDH1L1 | 10840 | A_23_P258887 | -0.8284 | 0.1491 | |
| SRP064894 | ALDH1L1 | 10840 | RNAseq | -1.8898 | 0.0012 | |
| SRP133303 | ALDH1L1 | 10840 | RNAseq | -1.2607 | 0.0354 | |
| SRP219564 | ALDH1L1 | 10840 | RNAseq | -0.3297 | 0.5898 | |
| TCGA | ALDH1L1 | 10840 | RNAseq | -0.9534 | 0.0238 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ALDH1L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH1L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH1L1 | 10840 | 17 | 0 | 13 | |
| GSE20123 | ALDH1L1 | 10840 | 17 | 0 | 13 | |
| GSE43470 | ALDH1L1 | 10840 | 20 | 0 | 23 | |
| GSE46452 | ALDH1L1 | 10840 | 14 | 5 | 40 | |
| GSE47630 | ALDH1L1 | 10840 | 17 | 4 | 19 | |
| GSE54993 | ALDH1L1 | 10840 | 2 | 7 | 61 | |
| GSE54994 | ALDH1L1 | 10840 | 31 | 3 | 19 | |
| GSE60625 | ALDH1L1 | 10840 | 0 | 6 | 5 | |
| GSE74703 | ALDH1L1 | 10840 | 17 | 0 | 19 | |
| GSE74704 | ALDH1L1 | 10840 | 13 | 0 | 7 | |
| TCGA | ALDH1L1 | 10840 | 55 | 6 | 35 |
Total number of gains: 203; Total number of losses: 31; Total Number of normals: 254.
Somatic mutations of ALDH1L1:
Generating mutation plots.
Highly correlated genes for ALDH1L1:
Showing top 20/138 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH1L1 | NICN1 | 0.724899 | 3 | 0 | 3 |
| ALDH1L1 | SEC14L3 | 0.71791 | 3 | 0 | 3 |
| ALDH1L1 | SV2C | 0.716136 | 3 | 0 | 3 |
| ALDH1L1 | DEPTOR | 0.704268 | 3 | 0 | 3 |
| ALDH1L1 | EFNA2 | 0.693051 | 3 | 0 | 3 |
| ALDH1L1 | MYO1A | 0.675446 | 4 | 0 | 3 |
| ALDH1L1 | TSHB | 0.674816 | 4 | 0 | 4 |
| ALDH1L1 | GPAT2 | 0.663472 | 3 | 0 | 3 |
| ALDH1L1 | GRID1 | 0.660614 | 3 | 0 | 3 |
| ALDH1L1 | A1CF | 0.651558 | 3 | 0 | 3 |
| ALDH1L1 | FBXL15 | 0.651528 | 3 | 0 | 3 |
| ALDH1L1 | DNAI1 | 0.638841 | 4 | 0 | 3 |
| ALDH1L1 | TXN2 | 0.638689 | 4 | 0 | 3 |
| ALDH1L1 | APOM | 0.633576 | 4 | 0 | 3 |
| ALDH1L1 | IFNA4 | 0.631527 | 4 | 0 | 3 |
| ALDH1L1 | ATOH8 | 0.630649 | 4 | 0 | 3 |
| ALDH1L1 | MC5R | 0.629668 | 4 | 0 | 3 |
| ALDH1L1 | TRIM2 | 0.626767 | 4 | 0 | 3 |
| ALDH1L1 | FAM171A1 | 0.626016 | 4 | 0 | 3 |
| ALDH1L1 | CER1 | 0.623958 | 3 | 0 | 3 |
For details and further investigation, click here
