| Full name: beta-ureidopropionase 1 | Alias Symbol: BUP1 | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 51733 | HGNC ID: HGNC:16297 | Ensembl Gene: ENSG00000100024 | OMIM ID: 606673 |
| Drug and gene relationship at DGIdb | |||
Expression of UPB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPB1 | 51733 | 228219_s_at | 0.1638 | 0.3743 | |
| GSE20347 | UPB1 | 51733 | 220507_s_at | -0.0005 | 0.9965 | |
| GSE23400 | UPB1 | 51733 | 220507_s_at | -0.1351 | 0.0005 | |
| GSE26886 | UPB1 | 51733 | 228219_s_at | 0.0773 | 0.5632 | |
| GSE29001 | UPB1 | 51733 | 220507_s_at | 0.0032 | 0.9832 | |
| GSE38129 | UPB1 | 51733 | 220507_s_at | -0.0947 | 0.1387 | |
| GSE45670 | UPB1 | 51733 | 228219_s_at | -0.0436 | 0.6159 | |
| GSE53622 | UPB1 | 51733 | 32086 | -1.7461 | 0.0000 | |
| GSE53624 | UPB1 | 51733 | 32086 | -1.5646 | 0.0000 | |
| GSE63941 | UPB1 | 51733 | 228219_s_at | 0.2507 | 0.0831 | |
| GSE77861 | UPB1 | 51733 | 228219_s_at | -0.0405 | 0.7777 | |
| GSE97050 | UPB1 | 51733 | A_33_P3308468 | -0.5158 | 0.2151 | |
| SRP133303 | UPB1 | 51733 | RNAseq | 0.0416 | 0.8191 | |
| SRP193095 | UPB1 | 51733 | RNAseq | -0.1085 | 0.4220 | |
| SRP219564 | UPB1 | 51733 | RNAseq | -0.3535 | 0.4877 | |
| TCGA | UPB1 | 51733 | RNAseq | -0.2555 | 0.6328 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by UPB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPB1 | 51733 | 5 | 7 | 18 | |
| GSE20123 | UPB1 | 51733 | 5 | 6 | 19 | |
| GSE43470 | UPB1 | 51733 | 3 | 6 | 34 | |
| GSE46452 | UPB1 | 51733 | 32 | 1 | 26 | |
| GSE47630 | UPB1 | 51733 | 8 | 5 | 27 | |
| GSE54993 | UPB1 | 51733 | 3 | 6 | 61 | |
| GSE54994 | UPB1 | 51733 | 11 | 7 | 35 | |
| GSE60625 | UPB1 | 51733 | 5 | 0 | 6 | |
| GSE74703 | UPB1 | 51733 | 3 | 5 | 28 | |
| GSE74704 | UPB1 | 51733 | 2 | 3 | 15 | |
| TCGA | UPB1 | 51733 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of UPB1:
Generating mutation plots.
Highly correlated genes for UPB1:
Showing top 20/637 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPB1 | OR2Z1 | 0.923108 | 3 | 0 | 3 |
| UPB1 | KRTAP20-1 | 0.922302 | 3 | 0 | 3 |
| UPB1 | OR10G8 | 0.901986 | 3 | 0 | 3 |
| UPB1 | MFSD2B | 0.875802 | 3 | 0 | 3 |
| UPB1 | CSTL1 | 0.873204 | 4 | 0 | 4 |
| UPB1 | FAM163B | 0.856845 | 3 | 0 | 3 |
| UPB1 | OR5AS1 | 0.830923 | 3 | 0 | 3 |
| UPB1 | BARHL2 | 0.809261 | 3 | 0 | 3 |
| UPB1 | SPATA19 | 0.798799 | 3 | 0 | 3 |
| UPB1 | MUC22 | 0.791357 | 3 | 0 | 3 |
| UPB1 | NCCRP1 | 0.782932 | 3 | 0 | 3 |
| UPB1 | OR10G3 | 0.78128 | 3 | 0 | 3 |
| UPB1 | GALNT9 | 0.779585 | 4 | 0 | 4 |
| UPB1 | TEN1 | 0.778152 | 3 | 0 | 3 |
| UPB1 | CLDN24 | 0.773698 | 3 | 0 | 3 |
| UPB1 | ESYT3 | 0.772716 | 3 | 0 | 3 |
| UPB1 | OTOP3 | 0.768548 | 3 | 0 | 3 |
| UPB1 | KPRP | 0.756495 | 3 | 0 | 3 |
| UPB1 | GPX6 | 0.755601 | 3 | 0 | 3 |
| UPB1 | BTBD19 | 0.755259 | 4 | 0 | 3 |
For details and further investigation, click here
