| Full name: extended synaptotagmin 3 | Alias Symbol: CHR3SYT | ||
| Type: protein-coding gene | Cytoband: 3q22.3 | ||
| Entrez ID: 83850 | HGNC ID: HGNC:24295 | Ensembl Gene: ENSG00000158220 | OMIM ID: 616692 |
| Drug and gene relationship at DGIdb | |||
Expression of ESYT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ESYT3 | 83850 | 239770_at | 0.6151 | 0.0298 | |
| GSE26886 | ESYT3 | 83850 | 239770_at | -0.2243 | 0.2758 | |
| GSE45670 | ESYT3 | 83850 | 239770_at | 0.3709 | 0.0299 | |
| GSE53622 | ESYT3 | 83850 | 75216 | -1.5033 | 0.0000 | |
| GSE53624 | ESYT3 | 83850 | 75216 | -1.2949 | 0.0000 | |
| GSE63941 | ESYT3 | 83850 | 239770_at | 0.4084 | 0.3385 | |
| GSE77861 | ESYT3 | 83850 | 1557793_at | -0.1489 | 0.1194 | |
| GSE97050 | ESYT3 | 83850 | A_33_P3235432 | 0.1819 | 0.4254 | |
| SRP007169 | ESYT3 | 83850 | RNAseq | -0.8864 | 0.2373 | |
| SRP064894 | ESYT3 | 83850 | RNAseq | 0.1010 | 0.7648 | |
| SRP133303 | ESYT3 | 83850 | RNAseq | -0.1887 | 0.3887 | |
| SRP159526 | ESYT3 | 83850 | RNAseq | 1.5410 | 0.0208 | |
| SRP193095 | ESYT3 | 83850 | RNAseq | 0.2450 | 0.2022 | |
| SRP219564 | ESYT3 | 83850 | RNAseq | 1.3687 | 0.1336 | |
| TCGA | ESYT3 | 83850 | RNAseq | -0.0274 | 0.9117 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ESYT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ESYT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ESYT3 | 83850 | 17 | 0 | 13 | |
| GSE20123 | ESYT3 | 83850 | 17 | 0 | 13 | |
| GSE43470 | ESYT3 | 83850 | 22 | 0 | 21 | |
| GSE46452 | ESYT3 | 83850 | 15 | 4 | 40 | |
| GSE47630 | ESYT3 | 83850 | 18 | 3 | 19 | |
| GSE54993 | ESYT3 | 83850 | 2 | 8 | 60 | |
| GSE54994 | ESYT3 | 83850 | 32 | 1 | 20 | |
| GSE60625 | ESYT3 | 83850 | 0 | 6 | 5 | |
| GSE74703 | ESYT3 | 83850 | 19 | 0 | 17 | |
| GSE74704 | ESYT3 | 83850 | 11 | 0 | 9 | |
| TCGA | ESYT3 | 83850 | 62 | 4 | 30 |
Total number of gains: 215; Total number of losses: 26; Total Number of normals: 247.
Somatic mutations of ESYT3:
Generating mutation plots.
Highly correlated genes for ESYT3:
Showing top 20/55 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ESYT3 | UPB1 | 0.772716 | 3 | 0 | 3 |
| ESYT3 | DEF6 | 0.720169 | 3 | 0 | 3 |
| ESYT3 | CRB1 | 0.710993 | 3 | 0 | 3 |
| ESYT3 | TPBGL | 0.69255 | 4 | 0 | 4 |
| ESYT3 | SFI1 | 0.665739 | 3 | 0 | 3 |
| ESYT3 | ACOX3 | 0.661505 | 3 | 0 | 3 |
| ESYT3 | ERBB2 | 0.645596 | 3 | 0 | 3 |
| ESYT3 | TEAD3 | 0.644539 | 3 | 0 | 3 |
| ESYT3 | ACOT8 | 0.637417 | 5 | 0 | 4 |
| ESYT3 | PRSS16 | 0.637155 | 3 | 0 | 3 |
| ESYT3 | B4GALT3 | 0.628289 | 5 | 0 | 4 |
| ESYT3 | SPATA19 | 0.627718 | 3 | 0 | 3 |
| ESYT3 | KRTAP4-1 | 0.624744 | 4 | 0 | 3 |
| ESYT3 | CDKL5 | 0.618703 | 3 | 0 | 3 |
| ESYT3 | ANKRD31 | 0.618628 | 4 | 0 | 3 |
| ESYT3 | SLC9A7 | 0.614636 | 4 | 0 | 3 |
| ESYT3 | RAB3D | 0.612328 | 3 | 0 | 3 |
| ESYT3 | RYR1 | 0.601449 | 5 | 0 | 3 |
| ESYT3 | MAPK14 | 0.599157 | 5 | 0 | 4 |
| ESYT3 | MAPK13 | 0.597154 | 4 | 0 | 3 |
For details and further investigation, click here
