| Full name: URB1 ribosome biogenesis homolog | Alias Symbol: KIAA0539|NPA1 | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 9875 | HGNC ID: HGNC:17344 | Ensembl Gene: ENSG00000142207 | OMIM ID: 608865 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of URB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | URB1 | 9875 | 212996_s_at | 0.4733 | 0.3053 | |
| GSE20347 | URB1 | 9875 | 212996_s_at | -0.0241 | 0.8950 | |
| GSE23400 | URB1 | 9875 | 212996_s_at | 0.0088 | 0.8670 | |
| GSE26886 | URB1 | 9875 | 212996_s_at | -0.0031 | 0.9874 | |
| GSE29001 | URB1 | 9875 | 212996_s_at | 0.1849 | 0.5367 | |
| GSE38129 | URB1 | 9875 | 212996_s_at | -0.0799 | 0.6092 | |
| GSE45670 | URB1 | 9875 | 212996_s_at | 0.0565 | 0.7773 | |
| GSE53622 | URB1 | 9875 | 13342 | -0.1206 | 0.1784 | |
| GSE53624 | URB1 | 9875 | 94235 | 0.0469 | 0.5194 | |
| GSE63941 | URB1 | 9875 | 212996_s_at | -0.7043 | 0.1803 | |
| GSE77861 | URB1 | 9875 | 208395_s_at | -0.0559 | 0.5362 | |
| GSE97050 | URB1 | 9875 | A_23_P57293 | -0.0521 | 0.8448 | |
| SRP007169 | URB1 | 9875 | RNAseq | 0.8568 | 0.0520 | |
| SRP008496 | URB1 | 9875 | RNAseq | 0.7492 | 0.0081 | |
| SRP064894 | URB1 | 9875 | RNAseq | 0.2344 | 0.2526 | |
| SRP133303 | URB1 | 9875 | RNAseq | -0.1265 | 0.5652 | |
| SRP159526 | URB1 | 9875 | RNAseq | -0.1215 | 0.7288 | |
| SRP193095 | URB1 | 9875 | RNAseq | 0.1301 | 0.2722 | |
| SRP219564 | URB1 | 9875 | RNAseq | 0.3361 | 0.3021 | |
| TCGA | URB1 | 9875 | RNAseq | 0.0074 | 0.8889 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by URB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of URB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | URB1 | 9875 | 2 | 9 | 19 | |
| GSE20123 | URB1 | 9875 | 2 | 10 | 18 | |
| GSE43470 | URB1 | 9875 | 3 | 7 | 33 | |
| GSE46452 | URB1 | 9875 | 1 | 21 | 37 | |
| GSE47630 | URB1 | 9875 | 6 | 17 | 17 | |
| GSE54993 | URB1 | 9875 | 9 | 1 | 60 | |
| GSE54994 | URB1 | 9875 | 1 | 8 | 44 | |
| GSE60625 | URB1 | 9875 | 0 | 0 | 11 | |
| GSE74703 | URB1 | 9875 | 3 | 5 | 28 | |
| GSE74704 | URB1 | 9875 | 1 | 6 | 13 | |
| TCGA | URB1 | 9875 | 9 | 36 | 51 |
Total number of gains: 37; Total number of losses: 120; Total Number of normals: 331.
Somatic mutations of URB1:
Generating mutation plots.
Highly correlated genes for URB1:
Showing all 14 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| URB1 | ALKBH4 | 0.636529 | 3 | 0 | 3 |
| URB1 | IL12B | 0.616988 | 3 | 0 | 3 |
| URB1 | TPK1 | 0.608534 | 3 | 0 | 3 |
| URB1 | MTOR | 0.5806 | 4 | 0 | 3 |
| URB1 | ZNF578 | 0.570228 | 3 | 0 | 3 |
| URB1 | MCM3AP | 0.545783 | 5 | 0 | 3 |
| URB1 | POGLUT1 | 0.540483 | 4 | 0 | 3 |
| URB1 | ZNF529 | 0.53301 | 5 | 0 | 3 |
| URB1 | NFRKB | 0.526753 | 4 | 0 | 3 |
| URB1 | USP20 | 0.521462 | 5 | 0 | 3 |
| URB1 | TM2D1 | 0.51568 | 5 | 0 | 3 |
| URB1 | CHD6 | 0.514056 | 4 | 0 | 3 |
| URB1 | ACP2 | 0.510267 | 4 | 0 | 3 |
| URB1 | SCAF4 | 0.509118 | 6 | 0 | 3 |
For details and further investigation, click here
