SCAF4

 

Full name: SR-related CTD associated factor 4 Alias Symbol: KIAA1172|DKFZp434E098|SRA4
Type: protein-coding gene Cytoband: 21q22.11
Entrez ID: 57466 HGNC ID: HGNC:19304 Ensembl Gene: ENSG00000156304 OMIM ID: 616023
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SCAF4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SCAF4 57466 226082_s_at 0.4881 0.3203
GSE20347 SCAF4 57466 222310_at 0.1131 0.7179
GSE23400 SCAF4 57466 222311_s_at 0.0498 0.3645
GSE26886 SCAF4 57466 226082_s_at -0.5467 0.0315
GSE29001 SCAF4 57466 222310_at 0.0712 0.9018
GSE38129 SCAF4 57466 222310_at 0.0254 0.9266
GSE45670 SCAF4 57466 226082_s_at 0.0292 0.7885
GSE53622 SCAF4 57466 56997 -0.3192 0.0000
GSE53624 SCAF4 57466 56997 -0.2473 0.0000
GSE63941 SCAF4 57466 226082_s_at -0.9664 0.0298
GSE77861 SCAF4 57466 226082_s_at 0.0068 0.9804
GSE97050 SCAF4 57466 A_23_P6223 -0.2773 0.2807
SRP007169 SCAF4 57466 RNAseq -0.3578 0.3067
SRP008496 SCAF4 57466 RNAseq -0.5286 0.0210
SRP064894 SCAF4 57466 RNAseq -0.0075 0.9687
SRP133303 SCAF4 57466 RNAseq -0.3847 0.0003
SRP159526 SCAF4 57466 RNAseq 0.0071 0.9666
SRP193095 SCAF4 57466 RNAseq -0.1012 0.4825
SRP219564 SCAF4 57466 RNAseq 0.1293 0.7092

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SCAF4 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of SCAF4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SCAF4 57466 3 10 17
GSE20123 SCAF4 57466 3 10 17
GSE43470 SCAF4 57466 2 9 32
GSE46452 SCAF4 57466 1 21 37
GSE47630 SCAF4 57466 6 17 17
GSE54993 SCAF4 57466 9 1 60
GSE54994 SCAF4 57466 1 9 43
GSE60625 SCAF4 57466 0 0 11
GSE74703 SCAF4 57466 2 6 28
GSE74704 SCAF4 57466 2 6 12
TCGA SCAF4 57466 8 37 51

Total number of gains: 37; Total number of losses: 126; Total Number of normals: 325.  

 

Somatic mutations of SCAF4:

 

Generating mutation plots.

 

Highly correlated genes for SCAF4:

 

Showing top 20/393 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SCAF4ELOF10.823319303
SCAF4UPF10.81013303
SCAF4NAA250.809516303
SCAF4MCM3AP0.808399404
SCAF4LSM14A0.802338303
SCAF4UBE2O0.781055303
SCAF4ANKRD540.766593303
SCAF4SOCS70.763719303
SCAF4UBR70.762306303
SCAF4DNAJC130.757357303
SCAF4VEZT0.755169404
SCAF4FOXK20.751443303
SCAF4ALG60.746121303
SCAF4BAP10.745215303
SCAF4ZNF4160.740435303
SCAF4ACSS30.735999303
SCAF4ZNF5780.730758404
SCAF4CHUK0.729512303
SCAF4CCAR10.72921303
SCAF4XKR80.72424303

For details and further investigation, click here