| Full name: interleukin 12B | Alias Symbol: CLMF|IL-12B|NKSF|CLMF2 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 3593 | HGNC ID: HGNC:5970 | Ensembl Gene: ENSG00000113302 | OMIM ID: 161561 |
| Related drugs: BRIAKINUMAB, USTEKINUMAB... [more] | |||
IL12B involved pathways:
Expression of IL12B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL12B | 3593 | 207901_at | 0.0556 | 0.8200 | |
| GSE20347 | IL12B | 3593 | 207901_at | 0.0149 | 0.7807 | |
| GSE23400 | IL12B | 3593 | 207901_at | -0.0159 | 0.4070 | |
| GSE26886 | IL12B | 3593 | 207901_at | -0.0185 | 0.8919 | |
| GSE29001 | IL12B | 3593 | 207901_at | 0.0894 | 0.4911 | |
| GSE38129 | IL12B | 3593 | 207901_at | 0.0276 | 0.5949 | |
| GSE45670 | IL12B | 3593 | 207901_at | 0.0820 | 0.2962 | |
| GSE53622 | IL12B | 3593 | 82824 | 0.0390 | 0.8065 | |
| GSE53624 | IL12B | 3593 | 82824 | -0.1192 | 0.3339 | |
| GSE63941 | IL12B | 3593 | 207901_at | -0.2332 | 0.0302 | |
| GSE77861 | IL12B | 3593 | 207901_at | 0.0062 | 0.9568 | |
| SRP133303 | IL12B | 3593 | RNAseq | 0.0300 | 0.9129 | |
| TCGA | IL12B | 3593 | RNAseq | 0.8709 | 0.2789 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL12B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL12B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL12B | 3593 | 0 | 11 | 19 | |
| GSE20123 | IL12B | 3593 | 0 | 11 | 19 | |
| GSE43470 | IL12B | 3593 | 2 | 10 | 31 | |
| GSE46452 | IL12B | 3593 | 0 | 27 | 32 | |
| GSE47630 | IL12B | 3593 | 0 | 20 | 20 | |
| GSE54993 | IL12B | 3593 | 9 | 2 | 59 | |
| GSE54994 | IL12B | 3593 | 1 | 16 | 36 | |
| GSE60625 | IL12B | 3593 | 0 | 0 | 11 | |
| GSE74703 | IL12B | 3593 | 2 | 8 | 26 | |
| GSE74704 | IL12B | 3593 | 0 | 6 | 14 | |
| TCGA | IL12B | 3593 | 4 | 37 | 55 |
Total number of gains: 18; Total number of losses: 148; Total Number of normals: 322.
Somatic mutations of IL12B:
Generating mutation plots.
Highly correlated genes for IL12B:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL12B | URB1 | 0.616988 | 3 | 0 | 3 |
| IL12B | HESX1 | 0.5974 | 4 | 0 | 3 |
| IL12B | IL10RA | 0.580094 | 4 | 0 | 3 |
| IL12B | SLC4A4 | 0.574132 | 3 | 0 | 3 |
| IL12B | RDH10 | 0.572563 | 3 | 0 | 3 |
| IL12B | ADORA3 | 0.563438 | 4 | 0 | 3 |
| IL12B | CDH18 | 0.560681 | 3 | 0 | 3 |
| IL12B | MTOR | 0.552814 | 3 | 0 | 3 |
| IL12B | FBXO4 | 0.547523 | 3 | 0 | 3 |
| IL12B | KIR2DL3 | 0.543715 | 3 | 0 | 3 |
| IL12B | IL2RB | 0.541512 | 7 | 0 | 4 |
| IL12B | AMBP | 0.541106 | 3 | 0 | 3 |
| IL12B | TNFSF8 | 0.539645 | 5 | 0 | 4 |
| IL12B | TNFRSF17 | 0.536616 | 5 | 0 | 4 |
| IL12B | CLCN6 | 0.533461 | 4 | 0 | 3 |
| IL12B | EBI3 | 0.531131 | 6 | 0 | 3 |
| IL12B | GRK4 | 0.530481 | 5 | 0 | 4 |
| IL12B | CD3E | 0.530063 | 5 | 0 | 3 |
| IL12B | LAPTM5 | 0.522849 | 4 | 0 | 4 |
| IL12B | NOL4 | 0.52273 | 4 | 0 | 3 |
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