| Full name: alkB homolog 4, lysine demethylase | Alias Symbol: FLJ20013 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 54784 | HGNC ID: HGNC:21900 | Ensembl Gene: ENSG00000160993 | OMIM ID: 613302 |
| Drug and gene relationship at DGIdb | |||
Expression of ALKBH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALKBH4 | 54784 | 222228_s_at | 0.3427 | 0.3000 | |
| GSE20347 | ALKBH4 | 54784 | 222228_s_at | 0.3836 | 0.0009 | |
| GSE23400 | ALKBH4 | 54784 | 222228_s_at | 0.1158 | 0.0123 | |
| GSE26886 | ALKBH4 | 54784 | 222228_s_at | 0.7038 | 0.0000 | |
| GSE29001 | ALKBH4 | 54784 | 222228_s_at | -0.0437 | 0.7667 | |
| GSE38129 | ALKBH4 | 54784 | 222228_s_at | 0.3235 | 0.0019 | |
| GSE45670 | ALKBH4 | 54784 | 222228_s_at | 0.2808 | 0.0452 | |
| GSE53622 | ALKBH4 | 54784 | 79536 | 0.4464 | 0.0001 | |
| GSE53624 | ALKBH4 | 54784 | 79536 | 0.5122 | 0.0000 | |
| GSE63941 | ALKBH4 | 54784 | 222228_s_at | -0.3565 | 0.2734 | |
| GSE77861 | ALKBH4 | 54784 | 222228_s_at | 0.1163 | 0.5527 | |
| GSE97050 | ALKBH4 | 54784 | A_23_P255523 | 0.1874 | 0.4101 | |
| SRP007169 | ALKBH4 | 54784 | RNAseq | 0.3960 | 0.4771 | |
| SRP008496 | ALKBH4 | 54784 | RNAseq | 1.0347 | 0.0269 | |
| SRP064894 | ALKBH4 | 54784 | RNAseq | 0.6585 | 0.0130 | |
| SRP133303 | ALKBH4 | 54784 | RNAseq | 0.2679 | 0.0472 | |
| SRP159526 | ALKBH4 | 54784 | RNAseq | 0.1726 | 0.3967 | |
| SRP193095 | ALKBH4 | 54784 | RNAseq | 0.2271 | 0.0345 | |
| SRP219564 | ALKBH4 | 54784 | RNAseq | 0.3808 | 0.2110 | |
| TCGA | ALKBH4 | 54784 | RNAseq | 0.1736 | 0.0298 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ALKBH4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALKBH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALKBH4 | 54784 | 13 | 0 | 17 | |
| GSE20123 | ALKBH4 | 54784 | 12 | 0 | 18 | |
| GSE43470 | ALKBH4 | 54784 | 6 | 3 | 34 | |
| GSE46452 | ALKBH4 | 54784 | 10 | 1 | 48 | |
| GSE47630 | ALKBH4 | 54784 | 7 | 3 | 30 | |
| GSE54993 | ALKBH4 | 54784 | 1 | 10 | 59 | |
| GSE54994 | ALKBH4 | 54784 | 15 | 4 | 34 | |
| GSE60625 | ALKBH4 | 54784 | 0 | 0 | 11 | |
| GSE74703 | ALKBH4 | 54784 | 6 | 2 | 28 | |
| GSE74704 | ALKBH4 | 54784 | 9 | 0 | 11 | |
| TCGA | ALKBH4 | 54784 | 53 | 6 | 37 |
Total number of gains: 132; Total number of losses: 29; Total Number of normals: 327.
Somatic mutations of ALKBH4:
Generating mutation plots.
Highly correlated genes for ALKBH4:
Showing top 20/487 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALKBH4 | SLC45A3 | 0.699503 | 4 | 0 | 3 |
| ALKBH4 | ZKSCAN5 | 0.688187 | 6 | 0 | 6 |
| ALKBH4 | PDE4A | 0.677199 | 3 | 0 | 3 |
| ALKBH4 | PRR15 | 0.664706 | 3 | 0 | 3 |
| ALKBH4 | POLR2J | 0.652372 | 11 | 0 | 9 |
| ALKBH4 | ZFP69 | 0.651162 | 4 | 0 | 4 |
| ALKBH4 | DVL2 | 0.650356 | 5 | 0 | 5 |
| ALKBH4 | GUSB | 0.646693 | 4 | 0 | 3 |
| ALKBH4 | HPS3 | 0.644269 | 3 | 0 | 3 |
| ALKBH4 | TMEM216 | 0.641475 | 4 | 0 | 3 |
| ALKBH4 | ZSCAN21 | 0.640151 | 4 | 0 | 3 |
| ALKBH4 | URB1 | 0.636529 | 3 | 0 | 3 |
| ALKBH4 | SHARPIN | 0.635389 | 5 | 0 | 3 |
| ALKBH4 | RIOK1 | 0.629832 | 5 | 0 | 5 |
| ALKBH4 | ZNF3 | 0.626018 | 9 | 0 | 7 |
| ALKBH4 | NSUN5 | 0.621892 | 8 | 0 | 7 |
| ALKBH4 | BUD31 | 0.619267 | 9 | 0 | 7 |
| ALKBH4 | RAD54L | 0.61861 | 4 | 0 | 3 |
| ALKBH4 | RHBDD2 | 0.618271 | 5 | 0 | 4 |
| ALKBH4 | PIK3R4 | 0.618146 | 6 | 0 | 4 |
For details and further investigation, click here
