| Full name: adenosine A3 receptor | Alias Symbol: AD026 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 140 | HGNC ID: HGNC:268 | Ensembl Gene: ENSG00000282608 | OMIM ID: 600445 |
| Drug and gene relationship at DGIdb | |||
ADORA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04071 | Sphingolipid signaling pathway |
Expression of ADORA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADORA3 | 140 | 206171_at | 0.0351 | 0.9714 | |
| GSE20347 | ADORA3 | 140 | 206171_at | -0.0764 | 0.5303 | |
| GSE23400 | ADORA3 | 140 | 206171_at | -0.1930 | 0.0000 | |
| GSE26886 | ADORA3 | 140 | 206171_at | -0.1926 | 0.3976 | |
| GSE29001 | ADORA3 | 140 | 206171_at | 0.0039 | 0.9859 | |
| GSE38129 | ADORA3 | 140 | 206171_at | -0.0714 | 0.4805 | |
| GSE45670 | ADORA3 | 140 | 206171_at | -0.1446 | 0.2236 | |
| GSE63941 | ADORA3 | 140 | 206171_at | -0.1723 | 0.3121 | |
| GSE77861 | ADORA3 | 140 | 206171_at | -0.0569 | 0.5649 | |
| GSE97050 | ADORA3 | 140 | A_23_P126540 | 0.1958 | 0.5167 | |
| SRP133303 | ADORA3 | 140 | RNAseq | 0.7095 | 0.1146 | |
| SRP159526 | ADORA3 | 140 | RNAseq | -0.0727 | 0.9316 | |
| SRP219564 | ADORA3 | 140 | RNAseq | 1.2316 | 0.0708 | |
| TCGA | ADORA3 | 140 | RNAseq | 0.3770 | 0.0913 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADORA3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ADORA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADORA3 | 140 | 0 | 10 | 20 | |
| GSE20123 | ADORA3 | 140 | 0 | 10 | 20 | |
| GSE43470 | ADORA3 | 140 | 0 | 8 | 35 | |
| GSE46452 | ADORA3 | 140 | 2 | 1 | 56 | |
| GSE47630 | ADORA3 | 140 | 9 | 5 | 26 | |
| GSE54993 | ADORA3 | 140 | 0 | 1 | 69 | |
| GSE54994 | ADORA3 | 140 | 7 | 4 | 42 | |
| GSE60625 | ADORA3 | 140 | 0 | 0 | 11 | |
| GSE74703 | ADORA3 | 140 | 0 | 7 | 29 | |
| GSE74704 | ADORA3 | 140 | 0 | 6 | 14 | |
| TCGA | ADORA3 | 140 | 7 | 27 | 62 |
Total number of gains: 25; Total number of losses: 79; Total Number of normals: 384.
Somatic mutations of ADORA3:
Generating mutation plots.
Highly correlated genes for ADORA3:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADORA3 | USH1C | 0.778051 | 3 | 0 | 3 |
| ADORA3 | GRID2 | 0.729183 | 3 | 0 | 3 |
| ADORA3 | CADPS | 0.717616 | 3 | 0 | 3 |
| ADORA3 | LIMD1 | 0.71108 | 3 | 0 | 3 |
| ADORA3 | RALYL | 0.704765 | 3 | 0 | 3 |
| ADORA3 | FAM163A | 0.701723 | 3 | 0 | 3 |
| ADORA3 | NOBOX | 0.697351 | 3 | 0 | 3 |
| ADORA3 | MSR1 | 0.687111 | 4 | 0 | 3 |
| ADORA3 | CHRD | 0.682116 | 3 | 0 | 3 |
| ADORA3 | MAGEL2 | 0.681808 | 3 | 0 | 3 |
| ADORA3 | ASPHD1 | 0.6818 | 3 | 0 | 3 |
| ADORA3 | LILRA1 | 0.681341 | 3 | 0 | 3 |
| ADORA3 | ABCB9 | 0.680325 | 3 | 0 | 3 |
| ADORA3 | PTGDR2 | 0.677565 | 3 | 0 | 3 |
| ADORA3 | MAGEA8 | 0.674747 | 3 | 0 | 3 |
| ADORA3 | SLC22A31 | 0.671954 | 3 | 0 | 3 |
| ADORA3 | TRIM46 | 0.668857 | 3 | 0 | 3 |
| ADORA3 | AGRP | 0.661431 | 5 | 0 | 4 |
| ADORA3 | B3GALT1 | 0.658308 | 5 | 0 | 3 |
| ADORA3 | ATP8B3 | 0.658083 | 4 | 0 | 4 |
For details and further investigation, click here
