| Full name: usherin | Alias Symbol: RP39 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 7399 | HGNC ID: HGNC:12601 | Ensembl Gene: ENSG00000042781 | OMIM ID: 608400 |
| Drug and gene relationship at DGIdb | |||
Expression of USH2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USH2A | 7399 | 207706_at | -0.0238 | 0.9164 | |
| GSE20347 | USH2A | 7399 | 207706_at | 0.0161 | 0.7548 | |
| GSE23400 | USH2A | 7399 | 207706_at | -0.0301 | 0.1608 | |
| GSE26886 | USH2A | 7399 | 207706_at | 0.0243 | 0.7942 | |
| GSE29001 | USH2A | 7399 | 207706_at | -0.0745 | 0.5737 | |
| GSE38129 | USH2A | 7399 | 207706_at | -0.0338 | 0.4506 | |
| GSE45670 | USH2A | 7399 | 207706_at | 0.0835 | 0.2329 | |
| GSE53622 | USH2A | 7399 | 7959 | -1.0125 | 0.0000 | |
| GSE53624 | USH2A | 7399 | 7959 | -0.7440 | 0.0001 | |
| GSE63941 | USH2A | 7399 | 207706_at | 0.0269 | 0.8298 | |
| GSE77861 | USH2A | 7399 | 207706_at | -0.0155 | 0.8245 | |
| SRP133303 | USH2A | 7399 | RNAseq | -1.1359 | 0.0039 | |
| SRP193095 | USH2A | 7399 | RNAseq | -0.9450 | 0.0002 | |
| SRP219564 | USH2A | 7399 | RNAseq | -1.3247 | 0.0072 | |
| TCGA | USH2A | 7399 | RNAseq | -0.4887 | 0.3093 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by USH2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USH2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USH2A | 7399 | 9 | 0 | 21 | |
| GSE20123 | USH2A | 7399 | 9 | 0 | 21 | |
| GSE43470 | USH2A | 7399 | 8 | 1 | 34 | |
| GSE46452 | USH2A | 7399 | 3 | 1 | 55 | |
| GSE47630 | USH2A | 7399 | 15 | 0 | 25 | |
| GSE54993 | USH2A | 7399 | 0 | 6 | 64 | |
| GSE54994 | USH2A | 7399 | 14 | 0 | 39 | |
| GSE60625 | USH2A | 7399 | 0 | 0 | 11 | |
| GSE74703 | USH2A | 7399 | 8 | 1 | 27 | |
| GSE74704 | USH2A | 7399 | 3 | 0 | 17 | |
| TCGA | USH2A | 7399 | 43 | 3 | 50 |
Total number of gains: 112; Total number of losses: 12; Total Number of normals: 364.
Somatic mutations of USH2A:
Generating mutation plots.
Highly correlated genes for USH2A:
Showing top 20/116 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USH2A | HAVCR1 | 0.712793 | 3 | 0 | 3 |
| USH2A | PCSK6 | 0.687949 | 3 | 0 | 3 |
| USH2A | GRIN2B | 0.687036 | 3 | 0 | 3 |
| USH2A | CYP17A1 | 0.665285 | 5 | 0 | 5 |
| USH2A | KRTAP4-7 | 0.663278 | 4 | 0 | 4 |
| USH2A | KCNB2 | 0.656355 | 3 | 0 | 3 |
| USH2A | OCM2 | 0.644378 | 3 | 0 | 3 |
| USH2A | RAVER2 | 0.629752 | 3 | 0 | 3 |
| USH2A | CPNE6 | 0.625894 | 3 | 0 | 3 |
| USH2A | TBR1 | 0.615525 | 4 | 0 | 3 |
| USH2A | SCG3 | 0.611936 | 3 | 0 | 3 |
| USH2A | SLC10A2 | 0.605747 | 4 | 0 | 3 |
| USH2A | ADCYAP1R1 | 0.601532 | 5 | 0 | 4 |
| USH2A | KCNV2 | 0.597601 | 8 | 0 | 6 |
| USH2A | NTNG1 | 0.597067 | 4 | 0 | 3 |
| USH2A | TEX13A | 0.594722 | 4 | 0 | 3 |
| USH2A | C2orf83 | 0.589216 | 4 | 0 | 4 |
| USH2A | CTRC | 0.588371 | 4 | 0 | 3 |
| USH2A | PRL | 0.588306 | 4 | 0 | 3 |
| USH2A | PRLH | 0.588166 | 5 | 0 | 3 |
For details and further investigation, click here
