| Full name: ADCYAP receptor type I | Alias Symbol: PAC1|PACAPR|PAC1R | ||
| Type: protein-coding gene | Cytoband: 7p14.3 | ||
| Entrez ID: 117 | HGNC ID: HGNC:242 | Ensembl Gene: ENSG00000078549 | OMIM ID: 102981 |
| Drug and gene relationship at DGIdb | |||
ADCYAP1R1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04713 | Circadian entrainment | |
| hsa04911 | Insulin secretion | |
| hsa04924 | Renin secretion |
Expression of ADCYAP1R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADCYAP1R1 | 117 | 226690_at | -0.7069 | 0.1403 | |
| GSE20347 | ADCYAP1R1 | 117 | 207151_at | 0.0777 | 0.3259 | |
| GSE23400 | ADCYAP1R1 | 117 | 207151_at | -0.0040 | 0.9296 | |
| GSE26886 | ADCYAP1R1 | 117 | 226690_at | -0.0271 | 0.8621 | |
| GSE29001 | ADCYAP1R1 | 117 | 207151_at | -0.0103 | 0.9552 | |
| GSE38129 | ADCYAP1R1 | 117 | 207151_at | -0.0153 | 0.8493 | |
| GSE45670 | ADCYAP1R1 | 117 | 226690_at | -0.7560 | 0.0000 | |
| GSE53622 | ADCYAP1R1 | 117 | 50178 | -1.3902 | 0.0000 | |
| GSE53624 | ADCYAP1R1 | 117 | 50178 | -0.8838 | 0.0000 | |
| GSE63941 | ADCYAP1R1 | 117 | 226690_at | 0.0625 | 0.8653 | |
| GSE77861 | ADCYAP1R1 | 117 | 207151_at | -0.1707 | 0.0742 | |
| GSE97050 | ADCYAP1R1 | 117 | A_23_P157109 | -1.2313 | 0.1581 | |
| SRP064894 | ADCYAP1R1 | 117 | RNAseq | -2.0040 | 0.0000 | |
| SRP133303 | ADCYAP1R1 | 117 | RNAseq | -2.1875 | 0.0009 | |
| SRP159526 | ADCYAP1R1 | 117 | RNAseq | -1.2085 | 0.1963 | |
| SRP219564 | ADCYAP1R1 | 117 | RNAseq | -0.8275 | 0.4677 | |
| TCGA | ADCYAP1R1 | 117 | RNAseq | -4.0609 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ADCYAP1R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADCYAP1R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADCYAP1R1 | 117 | 15 | 0 | 15 | |
| GSE20123 | ADCYAP1R1 | 117 | 15 | 0 | 15 | |
| GSE43470 | ADCYAP1R1 | 117 | 4 | 0 | 39 | |
| GSE46452 | ADCYAP1R1 | 117 | 11 | 1 | 47 | |
| GSE47630 | ADCYAP1R1 | 117 | 8 | 1 | 31 | |
| GSE54993 | ADCYAP1R1 | 117 | 0 | 6 | 64 | |
| GSE54994 | ADCYAP1R1 | 117 | 19 | 3 | 31 | |
| GSE60625 | ADCYAP1R1 | 117 | 0 | 0 | 11 | |
| GSE74703 | ADCYAP1R1 | 117 | 4 | 0 | 32 | |
| GSE74704 | ADCYAP1R1 | 117 | 9 | 0 | 11 | |
| TCGA | ADCYAP1R1 | 117 | 55 | 6 | 35 |
Total number of gains: 140; Total number of losses: 17; Total Number of normals: 331.
Somatic mutations of ADCYAP1R1:
Generating mutation plots.
Highly correlated genes for ADCYAP1R1:
Showing top 20/1111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADCYAP1R1 | RNF150 | 0.795658 | 4 | 0 | 4 |
| ADCYAP1R1 | DACT3 | 0.79289 | 4 | 0 | 4 |
| ADCYAP1R1 | ABCA6 | 0.787705 | 5 | 0 | 5 |
| ADCYAP1R1 | NEGR1 | 0.783288 | 5 | 0 | 5 |
| ADCYAP1R1 | MYOM1 | 0.783129 | 6 | 0 | 6 |
| ADCYAP1R1 | ALDH1A2 | 0.767565 | 6 | 0 | 6 |
| ADCYAP1R1 | C1QTNF7 | 0.765424 | 5 | 0 | 5 |
| ADCYAP1R1 | KCNT2 | 0.76416 | 4 | 0 | 4 |
| ADCYAP1R1 | ADRB3 | 0.761665 | 5 | 0 | 5 |
| ADCYAP1R1 | PCDH9 | 0.7569 | 4 | 0 | 4 |
| ADCYAP1R1 | FILIP1 | 0.756031 | 4 | 0 | 4 |
| ADCYAP1R1 | ANO5 | 0.749875 | 5 | 0 | 5 |
| ADCYAP1R1 | VMAC | 0.746893 | 3 | 0 | 3 |
| ADCYAP1R1 | EIF4E3 | 0.742613 | 5 | 0 | 5 |
| ADCYAP1R1 | MRGPRF | 0.742251 | 4 | 0 | 4 |
| ADCYAP1R1 | ARMCX1 | 0.741556 | 4 | 0 | 4 |
| ADCYAP1R1 | AP1S2 | 0.739805 | 3 | 0 | 3 |
| ADCYAP1R1 | RUNX1T1 | 0.739332 | 6 | 0 | 6 |
| ADCYAP1R1 | ADAMTSL1 | 0.73924 | 5 | 0 | 4 |
| ADCYAP1R1 | ID4 | 0.736748 | 3 | 0 | 3 |
For details and further investigation, click here
