| Full name: proprotein convertase subtilisin/kexin type 6 | Alias Symbol: SPC4 | ||
| Type: protein-coding gene | Cytoband: 15q26 | ||
| Entrez ID: 5046 | HGNC ID: HGNC:8569 | Ensembl Gene: ENSG00000140479 | OMIM ID: 167405 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK6 | 5046 | 211263_s_at | 0.0482 | 0.8567 | |
| GSE20347 | PCSK6 | 5046 | 211263_s_at | -0.1685 | 0.0494 | |
| GSE23400 | PCSK6 | 5046 | 211262_at | -0.1302 | 0.0014 | |
| GSE26886 | PCSK6 | 5046 | 211263_s_at | 0.0039 | 0.9800 | |
| GSE29001 | PCSK6 | 5046 | 211262_at | -0.1969 | 0.2650 | |
| GSE38129 | PCSK6 | 5046 | 211263_s_at | -0.2338 | 0.0169 | |
| GSE45670 | PCSK6 | 5046 | 211263_s_at | 0.0474 | 0.5971 | |
| GSE53622 | PCSK6 | 5046 | 66425 | -0.3411 | 0.0133 | |
| GSE53624 | PCSK6 | 5046 | 66425 | -0.4214 | 0.0001 | |
| GSE63941 | PCSK6 | 5046 | 242662_at | 0.9350 | 0.2585 | |
| GSE77861 | PCSK6 | 5046 | 211263_s_at | -0.0939 | 0.5831 | |
| GSE97050 | PCSK6 | 5046 | A_23_P151907 | -0.3122 | 0.3287 | |
| SRP007169 | PCSK6 | 5046 | RNAseq | -1.9589 | 0.0001 | |
| SRP008496 | PCSK6 | 5046 | RNAseq | -1.2443 | 0.0138 | |
| SRP064894 | PCSK6 | 5046 | RNAseq | -1.5664 | 0.0000 | |
| SRP133303 | PCSK6 | 5046 | RNAseq | -0.5050 | 0.0299 | |
| SRP159526 | PCSK6 | 5046 | RNAseq | 0.2851 | 0.2581 | |
| SRP193095 | PCSK6 | 5046 | RNAseq | -0.3352 | 0.0951 | |
| SRP219564 | PCSK6 | 5046 | RNAseq | 0.0600 | 0.9092 | |
| TCGA | PCSK6 | 5046 | RNAseq | -0.3591 | 0.0025 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PCSK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK6 | 5046 | 6 | 2 | 22 | |
| GSE20123 | PCSK6 | 5046 | 6 | 2 | 22 | |
| GSE43470 | PCSK6 | 5046 | 6 | 5 | 32 | |
| GSE46452 | PCSK6 | 5046 | 3 | 7 | 49 | |
| GSE47630 | PCSK6 | 5046 | 9 | 10 | 21 | |
| GSE54993 | PCSK6 | 5046 | 4 | 7 | 59 | |
| GSE54994 | PCSK6 | 5046 | 8 | 7 | 38 | |
| GSE60625 | PCSK6 | 5046 | 4 | 0 | 7 | |
| GSE74703 | PCSK6 | 5046 | 5 | 4 | 27 | |
| GSE74704 | PCSK6 | 5046 | 3 | 3 | 14 | |
| TCGA | PCSK6 | 5046 | 19 | 10 | 67 |
Total number of gains: 73; Total number of losses: 57; Total Number of normals: 358.
Somatic mutations of PCSK6:
Generating mutation plots.
Highly correlated genes for PCSK6:
Showing top 20/523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK6 | KCNQ1DN | 0.714768 | 4 | 0 | 4 |
| PCSK6 | CYP1B1-AS1 | 0.698268 | 3 | 0 | 3 |
| PCSK6 | USH2A | 0.687949 | 3 | 0 | 3 |
| PCSK6 | OPRM1 | 0.676418 | 3 | 0 | 3 |
| PCSK6 | EXD3 | 0.675067 | 5 | 0 | 4 |
| PCSK6 | KDM5C | 0.674876 | 3 | 0 | 3 |
| PCSK6 | SLC6A5 | 0.673532 | 4 | 0 | 3 |
| PCSK6 | BSN | 0.666666 | 4 | 0 | 4 |
| PCSK6 | ARF1 | 0.665923 | 3 | 0 | 3 |
| PCSK6 | DOK2 | 0.65898 | 4 | 0 | 3 |
| PCSK6 | PDE1B | 0.656749 | 6 | 0 | 4 |
| PCSK6 | GABRB2 | 0.653412 | 3 | 0 | 3 |
| PCSK6 | ZNF358 | 0.646653 | 4 | 0 | 4 |
| PCSK6 | RHAG | 0.64665 | 5 | 0 | 4 |
| PCSK6 | TPSD1 | 0.643501 | 5 | 0 | 4 |
| PCSK6 | GDF2 | 0.643215 | 5 | 0 | 3 |
| PCSK6 | GDAP1L1 | 0.641545 | 5 | 0 | 4 |
| PCSK6 | CCZ1 | 0.640677 | 3 | 0 | 3 |
| PCSK6 | JPH2 | 0.640263 | 4 | 0 | 3 |
| PCSK6 | CNTFR | 0.640048 | 5 | 0 | 5 |
For details and further investigation, click here
