| Full name: prolactin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 5617 | HGNC ID: HGNC:9445 | Ensembl Gene: ENSG00000172179 | OMIM ID: 176760 |
| Drug and gene relationship at DGIdb | |||
PRL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of PRL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRL | 5617 | 205445_at | -0.1030 | 0.8064 | |
| GSE20347 | PRL | 5617 | 205445_at | -0.0215 | 0.8480 | |
| GSE23400 | PRL | 5617 | 205445_at | -0.2106 | 0.0005 | |
| GSE26886 | PRL | 5617 | 205445_at | 0.1753 | 0.1311 | |
| GSE29001 | PRL | 5617 | 205445_at | -0.1773 | 0.2969 | |
| GSE38129 | PRL | 5617 | 205445_at | -0.0564 | 0.6810 | |
| GSE45670 | PRL | 5617 | 205445_at | 0.1406 | 0.2531 | |
| GSE53622 | PRL | 5617 | 3466 | 0.2993 | 0.0099 | |
| GSE53624 | PRL | 5617 | 3466 | 0.4889 | 0.0001 | |
| GSE63941 | PRL | 5617 | 205445_at | -0.6978 | 0.0083 | |
| GSE77861 | PRL | 5617 | 205445_at | -0.0889 | 0.4198 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRL | 5617 | 4 | 3 | 23 | |
| GSE20123 | PRL | 5617 | 4 | 3 | 23 | |
| GSE43470 | PRL | 5617 | 10 | 0 | 33 | |
| GSE46452 | PRL | 5617 | 1 | 9 | 49 | |
| GSE47630 | PRL | 5617 | 10 | 4 | 26 | |
| GSE54993 | PRL | 5617 | 1 | 1 | 68 | |
| GSE54994 | PRL | 5617 | 12 | 4 | 37 | |
| GSE60625 | PRL | 5617 | 0 | 1 | 10 | |
| GSE74703 | PRL | 5617 | 9 | 0 | 27 | |
| GSE74704 | PRL | 5617 | 1 | 1 | 18 | |
| TCGA | PRL | 5617 | 17 | 22 | 57 |
Total number of gains: 69; Total number of losses: 48; Total Number of normals: 371.
Somatic mutations of PRL:
Generating mutation plots.
Highly correlated genes for PRL:
Showing top 20/819 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRL | IL1RAPL2 | 0.785134 | 4 | 0 | 4 |
| PRL | IL1RL1 | 0.773743 | 4 | 0 | 4 |
| PRL | NPAP1 | 0.772756 | 4 | 0 | 4 |
| PRL | IL9R | 0.734766 | 5 | 0 | 5 |
| PRL | TCP10L | 0.72745 | 5 | 0 | 5 |
| PRL | RNF185-AS1 | 0.725006 | 5 | 0 | 5 |
| PRL | GAD2 | 0.71912 | 6 | 0 | 6 |
| PRL | BTN1A1 | 0.71827 | 6 | 0 | 5 |
| PRL | MTAP | 0.717464 | 4 | 0 | 4 |
| PRL | AQP6 | 0.712568 | 5 | 0 | 5 |
| PRL | ZNF460 | 0.707023 | 4 | 0 | 4 |
| PRL | OR10H3 | 0.706745 | 6 | 0 | 6 |
| PRL | KCNA4 | 0.705403 | 4 | 0 | 4 |
| PRL | HAND1 | 0.703244 | 5 | 0 | 5 |
| PRL | CHRM5 | 0.702831 | 5 | 0 | 5 |
| PRL | NCR1 | 0.702039 | 5 | 0 | 5 |
| PRL | NMNAT2 | 0.7007 | 3 | 0 | 3 |
| PRL | HECW1 | 0.700261 | 5 | 0 | 5 |
| PRL | PRODH2 | 0.698863 | 5 | 0 | 5 |
| PRL | PTPRJ | 0.698061 | 5 | 0 | 5 |
For details and further investigation, click here
