| Full name: glutamate ionotropic receptor NMDA type subunit 2B | Alias Symbol: GluN2B | ||
| Type: protein-coding gene | Cytoband: 12p13.1 | ||
| Entrez ID: 2904 | HGNC ID: HGNC:4586 | Ensembl Gene: ENSG00000273079 | OMIM ID: 138252 |
| Drug and gene relationship at DGIdb | |||
GRIN2B involved pathways:
Expression of GRIN2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIN2B | 2904 | 210411_s_at | 0.0639 | 0.7449 | |
| GSE20347 | GRIN2B | 2904 | 210411_s_at | -0.0573 | 0.4519 | |
| GSE23400 | GRIN2B | 2904 | 210412_at | -0.0825 | 0.0040 | |
| GSE26886 | GRIN2B | 2904 | 210411_s_at | -0.0072 | 0.9632 | |
| GSE29001 | GRIN2B | 2904 | 210411_s_at | -0.0842 | 0.7301 | |
| GSE38129 | GRIN2B | 2904 | 210411_s_at | -0.0940 | 0.1064 | |
| GSE45670 | GRIN2B | 2904 | 210411_s_at | 0.0241 | 0.7585 | |
| GSE53622 | GRIN2B | 2904 | 37113 | 0.4422 | 0.0007 | |
| GSE53624 | GRIN2B | 2904 | 37113 | 0.3633 | 0.0040 | |
| GSE63941 | GRIN2B | 2904 | 210411_s_at | -0.1077 | 0.5052 | |
| GSE77861 | GRIN2B | 2904 | 210411_s_at | -0.1827 | 0.0673 | |
| SRP133303 | GRIN2B | 2904 | RNAseq | -0.1343 | 0.5270 | |
| TCGA | GRIN2B | 2904 | RNAseq | -1.1458 | 0.2480 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRIN2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIN2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIN2B | 2904 | 6 | 2 | 22 | |
| GSE20123 | GRIN2B | 2904 | 6 | 2 | 22 | |
| GSE43470 | GRIN2B | 2904 | 9 | 4 | 30 | |
| GSE46452 | GRIN2B | 2904 | 10 | 1 | 48 | |
| GSE47630 | GRIN2B | 2904 | 14 | 1 | 25 | |
| GSE54993 | GRIN2B | 2904 | 1 | 9 | 60 | |
| GSE54994 | GRIN2B | 2904 | 10 | 2 | 41 | |
| GSE60625 | GRIN2B | 2904 | 0 | 1 | 10 | |
| GSE74703 | GRIN2B | 2904 | 9 | 3 | 24 | |
| GSE74704 | GRIN2B | 2904 | 4 | 1 | 15 | |
| TCGA | GRIN2B | 2904 | 40 | 6 | 50 |
Total number of gains: 109; Total number of losses: 32; Total Number of normals: 347.
Somatic mutations of GRIN2B:
Generating mutation plots.
Highly correlated genes for GRIN2B:
Showing top 20/479 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIN2B | OR2S2 | 0.73187 | 4 | 0 | 3 |
| GRIN2B | VGF | 0.702773 | 4 | 0 | 4 |
| GRIN2B | PRTN3 | 0.697213 | 3 | 0 | 3 |
| GRIN2B | USH2A | 0.687036 | 3 | 0 | 3 |
| GRIN2B | LMAN1 | 0.682379 | 3 | 0 | 3 |
| GRIN2B | CGA | 0.67836 | 5 | 0 | 4 |
| GRIN2B | HAVCR1 | 0.676774 | 3 | 0 | 3 |
| GRIN2B | TAAR2 | 0.676613 | 3 | 0 | 3 |
| GRIN2B | EPO | 0.674095 | 4 | 0 | 4 |
| GRIN2B | MAG | 0.665452 | 3 | 0 | 3 |
| GRIN2B | CDH10 | 0.663257 | 4 | 0 | 4 |
| GRIN2B | CAMK4 | 0.66319 | 4 | 0 | 3 |
| GRIN2B | SYT13 | 0.662865 | 3 | 0 | 3 |
| GRIN2B | FEZF2 | 0.662191 | 3 | 0 | 3 |
| GRIN2B | KLK14 | 0.662165 | 3 | 0 | 3 |
| GRIN2B | HRH4 | 0.659072 | 4 | 0 | 3 |
| GRIN2B | GLP1R | 0.65598 | 4 | 0 | 3 |
| GRIN2B | CLEC4E | 0.654741 | 4 | 0 | 3 |
| GRIN2B | KCNA4 | 0.653584 | 5 | 0 | 4 |
| GRIN2B | CRYBB1 | 0.651645 | 3 | 0 | 3 |
For details and further investigation, click here
