| Full name: ubiquitin specific peptidase 53 | Alias Symbol: KIAA1350 | ||
| Type: protein-coding gene | Cytoband: 4q26 | ||
| Entrez ID: 54532 | HGNC ID: HGNC:29255 | Ensembl Gene: ENSG00000145390 | OMIM ID: 617431 |
| Drug and gene relationship at DGIdb | |||
Expression of USP53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP53 | 54532 | 230083_at | -0.9341 | 0.1140 | |
| GSE20347 | USP53 | 54532 | 216775_at | -0.3427 | 0.0005 | |
| GSE23400 | USP53 | 54532 | 216775_at | -0.0870 | 0.0037 | |
| GSE26886 | USP53 | 54532 | 230083_at | -0.5901 | 0.0110 | |
| GSE29001 | USP53 | 54532 | 216775_at | -0.4191 | 0.0710 | |
| GSE38129 | USP53 | 54532 | 216775_at | -0.3261 | 0.0005 | |
| GSE45670 | USP53 | 54532 | 231817_at | -0.8679 | 0.0000 | |
| GSE53622 | USP53 | 54532 | 159954 | -1.2273 | 0.0000 | |
| GSE53624 | USP53 | 54532 | 159954 | -1.4219 | 0.0000 | |
| GSE63941 | USP53 | 54532 | 231817_at | -0.2978 | 0.6216 | |
| GSE77861 | USP53 | 54532 | 230083_at | 0.0015 | 0.9982 | |
| GSE97050 | USP53 | 54532 | A_24_P137522 | -0.5055 | 0.1608 | |
| SRP007169 | USP53 | 54532 | RNAseq | -2.5675 | 0.0000 | |
| SRP008496 | USP53 | 54532 | RNAseq | -2.5366 | 0.0000 | |
| SRP064894 | USP53 | 54532 | RNAseq | -1.8779 | 0.0000 | |
| SRP133303 | USP53 | 54532 | RNAseq | -0.7666 | 0.0000 | |
| SRP159526 | USP53 | 54532 | RNAseq | -1.5292 | 0.0000 | |
| SRP193095 | USP53 | 54532 | RNAseq | -1.0879 | 0.0000 | |
| SRP219564 | USP53 | 54532 | RNAseq | -0.7551 | 0.1933 | |
| TCGA | USP53 | 54532 | RNAseq | -0.4191 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by USP53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP53 | 54532 | 1 | 13 | 16 | |
| GSE20123 | USP53 | 54532 | 1 | 13 | 16 | |
| GSE43470 | USP53 | 54532 | 0 | 13 | 30 | |
| GSE46452 | USP53 | 54532 | 1 | 36 | 22 | |
| GSE47630 | USP53 | 54532 | 0 | 22 | 18 | |
| GSE54993 | USP53 | 54532 | 9 | 0 | 61 | |
| GSE54994 | USP53 | 54532 | 1 | 10 | 42 | |
| GSE60625 | USP53 | 54532 | 0 | 1 | 10 | |
| GSE74703 | USP53 | 54532 | 0 | 11 | 25 | |
| GSE74704 | USP53 | 54532 | 0 | 7 | 13 | |
| TCGA | USP53 | 54532 | 9 | 34 | 53 |
Total number of gains: 22; Total number of losses: 160; Total Number of normals: 306.
Somatic mutations of USP53:
Generating mutation plots.
Highly correlated genes for USP53:
Showing top 20/1282 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP53 | CA13 | 0.766768 | 3 | 0 | 3 |
| USP53 | OCRL | 0.743656 | 3 | 0 | 3 |
| USP53 | EIF4E3 | 0.740152 | 6 | 0 | 6 |
| USP53 | C4orf3 | 0.737709 | 5 | 0 | 5 |
| USP53 | ZNF555 | 0.734197 | 5 | 0 | 5 |
| USP53 | CASQ2 | 0.733065 | 5 | 0 | 5 |
| USP53 | MPP7 | 0.731971 | 6 | 0 | 6 |
| USP53 | CLEC3B | 0.73061 | 3 | 0 | 3 |
| USP53 | CASC3 | 0.730148 | 3 | 0 | 3 |
| USP53 | SH3BGRL2 | 0.729937 | 6 | 0 | 6 |
| USP53 | SORCS1 | 0.725449 | 4 | 0 | 4 |
| USP53 | ZNF662 | 0.723513 | 6 | 0 | 6 |
| USP53 | KIAA1191 | 0.723369 | 6 | 0 | 6 |
| USP53 | NPY1R | 0.723228 | 3 | 0 | 3 |
| USP53 | UBR1 | 0.722438 | 3 | 0 | 3 |
| USP53 | CTTNBP2NL | 0.721784 | 6 | 0 | 6 |
| USP53 | FAM219B | 0.720867 | 3 | 0 | 3 |
| USP53 | ZNF514 | 0.719994 | 3 | 0 | 3 |
| USP53 | RPL37A | 0.719765 | 3 | 0 | 3 |
| USP53 | PFDN5 | 0.716759 | 5 | 0 | 4 |
For details and further investigation, click here
