| Full name: ubiquitin protein ligase E3 component n-recognin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q15.2 | ||
| Entrez ID: 197131 | HGNC ID: HGNC:16808 | Ensembl Gene: ENSG00000159459 | OMIM ID: 605981 |
| Drug and gene relationship at DGIdb | |||
Expression of UBR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBR1 | 197131 | 226921_at | -0.2882 | 0.5948 | |
| GSE26886 | UBR1 | 197131 | 226921_at | 0.6038 | 0.0093 | |
| GSE45670 | UBR1 | 197131 | 226921_at | -0.2857 | 0.1100 | |
| GSE53622 | UBR1 | 197131 | 12917 | 0.0513 | 0.6174 | |
| GSE53624 | UBR1 | 197131 | 12917 | 0.0169 | 0.8599 | |
| GSE63941 | UBR1 | 197131 | 226921_at | -0.6608 | 0.1400 | |
| GSE77861 | UBR1 | 197131 | 226921_at | 0.7701 | 0.0140 | |
| GSE97050 | UBR1 | 197131 | A_23_P152066 | -0.5118 | 0.1790 | |
| SRP007169 | UBR1 | 197131 | RNAseq | 1.4005 | 0.0005 | |
| SRP008496 | UBR1 | 197131 | RNAseq | 1.2781 | 0.0000 | |
| SRP064894 | UBR1 | 197131 | RNAseq | 0.0166 | 0.9503 | |
| SRP133303 | UBR1 | 197131 | RNAseq | 0.2896 | 0.0038 | |
| SRP159526 | UBR1 | 197131 | RNAseq | -0.0609 | 0.8725 | |
| SRP193095 | UBR1 | 197131 | RNAseq | 0.4110 | 0.0015 | |
| SRP219564 | UBR1 | 197131 | RNAseq | -0.1806 | 0.6710 | |
| TCGA | UBR1 | 197131 | RNAseq | -0.1861 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by UBR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBR1 | 197131 | 4 | 5 | 21 | |
| GSE20123 | UBR1 | 197131 | 4 | 6 | 20 | |
| GSE43470 | UBR1 | 197131 | 4 | 5 | 34 | |
| GSE46452 | UBR1 | 197131 | 3 | 7 | 49 | |
| GSE47630 | UBR1 | 197131 | 8 | 10 | 22 | |
| GSE54993 | UBR1 | 197131 | 4 | 6 | 60 | |
| GSE54994 | UBR1 | 197131 | 5 | 7 | 41 | |
| GSE60625 | UBR1 | 197131 | 4 | 0 | 7 | |
| GSE74703 | UBR1 | 197131 | 4 | 3 | 29 | |
| GSE74704 | UBR1 | 197131 | 3 | 3 | 14 | |
| TCGA | UBR1 | 197131 | 12 | 17 | 67 |
Total number of gains: 55; Total number of losses: 69; Total Number of normals: 364.
Somatic mutations of UBR1:
Generating mutation plots.
Highly correlated genes for UBR1:
Showing top 20/745 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBR1 | NEDD1 | 0.844345 | 3 | 0 | 3 |
| UBR1 | PAK1 | 0.820918 | 3 | 0 | 3 |
| UBR1 | ST13 | 0.813544 | 3 | 0 | 3 |
| UBR1 | RBMX2 | 0.811516 | 3 | 0 | 3 |
| UBR1 | IDH3A | 0.796914 | 3 | 0 | 3 |
| UBR1 | NUP107 | 0.794373 | 3 | 0 | 3 |
| UBR1 | C9orf78 | 0.792219 | 3 | 0 | 3 |
| UBR1 | CPSF3 | 0.790307 | 3 | 0 | 3 |
| UBR1 | PET117 | 0.789619 | 3 | 0 | 3 |
| UBR1 | ETS2 | 0.780961 | 3 | 0 | 3 |
| UBR1 | SPTBN1 | 0.775087 | 5 | 0 | 5 |
| UBR1 | RNF14 | 0.771389 | 3 | 0 | 3 |
| UBR1 | C1orf131 | 0.770574 | 3 | 0 | 3 |
| UBR1 | ASPH | 0.767676 | 3 | 0 | 3 |
| UBR1 | EP400 | 0.767289 | 3 | 0 | 3 |
| UBR1 | DHX40 | 0.763749 | 3 | 0 | 3 |
| UBR1 | IFNGR1 | 0.755071 | 3 | 0 | 3 |
| UBR1 | PHIP | 0.752582 | 3 | 0 | 3 |
| UBR1 | MINPP1 | 0.746966 | 3 | 0 | 3 |
| UBR1 | PMPCB | 0.742109 | 3 | 0 | 3 |
For details and further investigation, click here
