| Full name: neuropeptide Y receptor Y1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q32.2 | ||
| Entrez ID: 4886 | HGNC ID: HGNC:7956 | Ensembl Gene: ENSG00000164128 | OMIM ID: 162641 |
| Drug and gene relationship at DGIdb | |||
NPY1R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04923 | Regulation of lipolysis in adipocytes |
Expression of NPY1R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPY1R | 4886 | 205440_s_at | -1.0429 | 0.1004 | |
| GSE20347 | NPY1R | 4886 | 205440_s_at | -0.2760 | 0.0039 | |
| GSE23400 | NPY1R | 4886 | 205440_s_at | -0.2672 | 0.0000 | |
| GSE26886 | NPY1R | 4886 | 205440_s_at | 0.2298 | 0.4005 | |
| GSE29001 | NPY1R | 4886 | 205440_s_at | -0.1775 | 0.4404 | |
| GSE38129 | NPY1R | 4886 | 205440_s_at | -0.9672 | 0.0002 | |
| GSE45670 | NPY1R | 4886 | 205440_s_at | -2.1380 | 0.0000 | |
| GSE63941 | NPY1R | 4886 | 205440_s_at | 0.0572 | 0.8782 | |
| GSE77861 | NPY1R | 4886 | 205440_s_at | -0.0319 | 0.6903 | |
| GSE97050 | NPY1R | 4886 | A_23_P69699 | -0.6058 | 0.1534 | |
| SRP064894 | NPY1R | 4886 | RNAseq | -2.5569 | 0.0000 | |
| SRP133303 | NPY1R | 4886 | RNAseq | -2.7693 | 0.0000 | |
| TCGA | NPY1R | 4886 | RNAseq | -1.5560 | 0.0078 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by NPY1R expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NPY1R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPY1R | 4886 | 0 | 11 | 19 | |
| GSE20123 | NPY1R | 4886 | 0 | 11 | 19 | |
| GSE43470 | NPY1R | 4886 | 0 | 14 | 29 | |
| GSE46452 | NPY1R | 4886 | 1 | 36 | 22 | |
| GSE47630 | NPY1R | 4886 | 0 | 22 | 18 | |
| GSE54993 | NPY1R | 4886 | 10 | 0 | 60 | |
| GSE54994 | NPY1R | 4886 | 1 | 12 | 40 | |
| GSE60625 | NPY1R | 4886 | 0 | 0 | 11 | |
| GSE74703 | NPY1R | 4886 | 0 | 12 | 24 | |
| GSE74704 | NPY1R | 4886 | 0 | 5 | 15 | |
| TCGA | NPY1R | 4886 | 10 | 35 | 51 |
Total number of gains: 22; Total number of losses: 158; Total Number of normals: 308.
Somatic mutations of NPY1R:
Generating mutation plots.
Highly correlated genes for NPY1R:
Showing top 20/751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPY1R | GFRA1 | 0.902899 | 3 | 0 | 3 |
| NPY1R | ANGPTL1 | 0.888608 | 3 | 0 | 3 |
| NPY1R | FAM13C | 0.84826 | 3 | 0 | 3 |
| NPY1R | FBXL3 | 0.827382 | 3 | 0 | 3 |
| NPY1R | ZMAT1 | 0.820754 | 3 | 0 | 3 |
| NPY1R | SMTNL2 | 0.817779 | 3 | 0 | 3 |
| NPY1R | IGSF10 | 0.81682 | 3 | 0 | 3 |
| NPY1R | MAMDC2 | 0.814751 | 3 | 0 | 3 |
| NPY1R | XKR4 | 0.804887 | 3 | 0 | 3 |
| NPY1R | STARD9 | 0.801751 | 3 | 0 | 3 |
| NPY1R | KLHL15 | 0.796397 | 3 | 0 | 3 |
| NPY1R | RHOU | 0.793951 | 3 | 0 | 3 |
| NPY1R | MYOCD | 0.793826 | 3 | 0 | 3 |
| NPY1R | NIPSNAP3B | 0.79344 | 4 | 0 | 4 |
| NPY1R | NFIA | 0.789594 | 3 | 0 | 3 |
| NPY1R | FIBIN | 0.786077 | 3 | 0 | 3 |
| NPY1R | EBF1 | 0.781364 | 3 | 0 | 3 |
| NPY1R | ABCA6 | 0.780211 | 6 | 0 | 6 |
| NPY1R | FILIP1 | 0.779758 | 3 | 0 | 3 |
| NPY1R | ALDH1A2 | 0.774181 | 3 | 0 | 3 |
For details and further investigation, click here
