| Full name: CASC3 exon junction complex subunit | Alias Symbol: MLN51|BTZ | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 22794 | HGNC ID: HGNC:17040 | Ensembl Gene: ENSG00000108349 | OMIM ID: 606504 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CASC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CASC3 | 22794 | 9487 | -1.0767 | 0.0000 | |
| GSE53624 | CASC3 | 22794 | 9487 | -1.5927 | 0.0000 | |
| GSE97050 | CASC3 | 22794 | A_23_P374288 | -0.7624 | 0.1980 | |
| SRP007169 | CASC3 | 22794 | RNAseq | 1.1279 | 0.0211 | |
| SRP008496 | CASC3 | 22794 | RNAseq | 0.8662 | 0.0110 | |
| SRP064894 | CASC3 | 22794 | RNAseq | 0.0894 | 0.3308 | |
| SRP133303 | CASC3 | 22794 | RNAseq | -0.0590 | 0.5868 | |
| SRP159526 | CASC3 | 22794 | RNAseq | 0.0683 | 0.7232 | |
| SRP193095 | CASC3 | 22794 | RNAseq | 0.2753 | 0.0001 | |
| SRP219564 | CASC3 | 22794 | RNAseq | -0.1700 | 0.4820 | |
| TCGA | CASC3 | 22794 | RNAseq | -0.0687 | 0.1107 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CASC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASC3 | 22794 | 8 | 1 | 21 | |
| GSE20123 | CASC3 | 22794 | 8 | 1 | 21 | |
| GSE43470 | CASC3 | 22794 | 1 | 2 | 40 | |
| GSE46452 | CASC3 | 22794 | 34 | 0 | 25 | |
| GSE47630 | CASC3 | 22794 | 8 | 1 | 31 | |
| GSE54993 | CASC3 | 22794 | 3 | 4 | 63 | |
| GSE54994 | CASC3 | 22794 | 8 | 5 | 40 | |
| GSE60625 | CASC3 | 22794 | 4 | 0 | 7 | |
| GSE74703 | CASC3 | 22794 | 1 | 1 | 34 | |
| GSE74704 | CASC3 | 22794 | 5 | 1 | 14 | |
| TCGA | CASC3 | 22794 | 23 | 8 | 65 |
Total number of gains: 103; Total number of losses: 24; Total Number of normals: 361.
Somatic mutations of CASC3:
Generating mutation plots.
Highly correlated genes for CASC3:
Showing top 20/581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASC3 | CDX1 | 0.860405 | 3 | 0 | 3 |
| CASC3 | TEAD3 | 0.854384 | 3 | 0 | 3 |
| CASC3 | HADHB | 0.846303 | 3 | 0 | 3 |
| CASC3 | ATRNL1 | 0.845859 | 3 | 0 | 3 |
| CASC3 | TF | 0.840785 | 3 | 0 | 3 |
| CASC3 | SP1 | 0.83704 | 3 | 0 | 3 |
| CASC3 | SH3BGRL2 | 0.832574 | 3 | 0 | 3 |
| CASC3 | C18orf25 | 0.832235 | 3 | 0 | 3 |
| CASC3 | RRAGD | 0.82676 | 3 | 0 | 3 |
| CASC3 | SASH1 | 0.818543 | 3 | 0 | 3 |
| CASC3 | RMND5B | 0.81611 | 3 | 0 | 3 |
| CASC3 | SLC16A6 | 0.815984 | 3 | 0 | 3 |
| CASC3 | WDR26 | 0.814326 | 3 | 0 | 3 |
| CASC3 | YOD1 | 0.813229 | 3 | 0 | 3 |
| CASC3 | CAST | 0.812011 | 3 | 0 | 3 |
| CASC3 | RNF141 | 0.810369 | 3 | 0 | 3 |
| CASC3 | SIM2 | 0.808986 | 3 | 0 | 3 |
| CASC3 | ACADVL | 0.808715 | 3 | 0 | 3 |
| CASC3 | TRIP10 | 0.806994 | 3 | 0 | 3 |
| CASC3 | MGLL | 0.805844 | 3 | 0 | 3 |
For details and further investigation, click here
