| Full name: VPS53 subunit of GARP complex | Alias Symbol: FLJ10979|HCCS1 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 55275 | HGNC ID: HGNC:25608 | Ensembl Gene: ENSG00000141252 | OMIM ID: 615850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS53 | 55275 | 227229_at | -0.3267 | 0.5135 | |
| GSE20347 | VPS53 | 55275 | 221707_s_at | -0.1070 | 0.2180 | |
| GSE23400 | VPS53 | 55275 | 221707_s_at | -0.2083 | 0.0000 | |
| GSE26886 | VPS53 | 55275 | 227229_at | -0.0951 | 0.7147 | |
| GSE29001 | VPS53 | 55275 | 221707_s_at | -0.1633 | 0.3709 | |
| GSE38129 | VPS53 | 55275 | 221707_s_at | -0.1416 | 0.0415 | |
| GSE45670 | VPS53 | 55275 | 227229_at | 0.0640 | 0.5691 | |
| GSE53622 | VPS53 | 55275 | 103934 | -0.4671 | 0.0000 | |
| GSE53624 | VPS53 | 55275 | 103934 | -0.3709 | 0.0000 | |
| GSE63941 | VPS53 | 55275 | 227229_at | -0.5034 | 0.2677 | |
| GSE77861 | VPS53 | 55275 | 227229_at | -0.1784 | 0.4689 | |
| GSE97050 | VPS53 | 55275 | A_24_P147398 | -0.0997 | 0.6362 | |
| SRP007169 | VPS53 | 55275 | RNAseq | 0.5092 | 0.1864 | |
| SRP008496 | VPS53 | 55275 | RNAseq | 0.5984 | 0.0074 | |
| SRP064894 | VPS53 | 55275 | RNAseq | -0.2831 | 0.0937 | |
| SRP133303 | VPS53 | 55275 | RNAseq | -0.2404 | 0.0539 | |
| SRP159526 | VPS53 | 55275 | RNAseq | -0.2062 | 0.2439 | |
| SRP193095 | VPS53 | 55275 | RNAseq | -0.0359 | 0.7938 | |
| SRP219564 | VPS53 | 55275 | RNAseq | -0.2011 | 0.5737 | |
| TCGA | VPS53 | 55275 | RNAseq | -0.1520 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS53 | 55275 | 5 | 2 | 23 | |
| GSE20123 | VPS53 | 55275 | 5 | 3 | 22 | |
| GSE43470 | VPS53 | 55275 | 1 | 7 | 35 | |
| GSE46452 | VPS53 | 55275 | 34 | 1 | 24 | |
| GSE47630 | VPS53 | 55275 | 8 | 1 | 31 | |
| GSE54993 | VPS53 | 55275 | 8 | 3 | 59 | |
| GSE54994 | VPS53 | 55275 | 7 | 9 | 37 | |
| GSE60625 | VPS53 | 55275 | 4 | 0 | 7 | |
| GSE74703 | VPS53 | 55275 | 1 | 4 | 31 | |
| GSE74704 | VPS53 | 55275 | 3 | 1 | 16 | |
| TCGA | VPS53 | 55275 | 19 | 21 | 56 |
Total number of gains: 95; Total number of losses: 52; Total Number of normals: 341.
Somatic mutations of VPS53:
Generating mutation plots.
Highly correlated genes for VPS53:
Showing top 20/644 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS53 | SLC10A7 | 0.781375 | 3 | 0 | 3 |
| VPS53 | OSBPL8 | 0.771116 | 3 | 0 | 3 |
| VPS53 | RIT2 | 0.763181 | 3 | 0 | 3 |
| VPS53 | LPIN2 | 0.754224 | 3 | 0 | 3 |
| VPS53 | ABHD16A | 0.750357 | 3 | 0 | 3 |
| VPS53 | GPBP1 | 0.742624 | 3 | 0 | 3 |
| VPS53 | ARMCX5 | 0.727715 | 3 | 0 | 3 |
| VPS53 | GUK1 | 0.726899 | 3 | 0 | 3 |
| VPS53 | MON2 | 0.719939 | 3 | 0 | 3 |
| VPS53 | C12orf29 | 0.718939 | 3 | 0 | 3 |
| VPS53 | KDM5B | 0.713275 | 3 | 0 | 3 |
| VPS53 | CEP44 | 0.710447 | 3 | 0 | 3 |
| VPS53 | MYO1D | 0.71043 | 3 | 0 | 3 |
| VPS53 | ZDHHC21 | 0.70997 | 4 | 0 | 4 |
| VPS53 | DIP2B | 0.709196 | 3 | 0 | 3 |
| VPS53 | FDX1 | 0.708721 | 3 | 0 | 3 |
| VPS53 | GOLGA4 | 0.706146 | 3 | 0 | 3 |
| VPS53 | MTPN | 0.706052 | 4 | 0 | 4 |
| VPS53 | ART1 | 0.705772 | 3 | 0 | 3 |
| VPS53 | RNF135 | 0.705152 | 4 | 0 | 4 |
For details and further investigation, click here
