| Full name: ferredoxin 1 | Alias Symbol: ADX | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 2230 | HGNC ID: HGNC:3638 | Ensembl Gene: ENSG00000137714 | OMIM ID: 103260 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FDX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FDX1 | 2230 | 203647_s_at | -0.2231 | 0.4689 | |
| GSE20347 | FDX1 | 2230 | 203647_s_at | -0.4900 | 0.0077 | |
| GSE23400 | FDX1 | 2230 | 203647_s_at | -0.0118 | 0.8920 | |
| GSE26886 | FDX1 | 2230 | 203647_s_at | -0.1087 | 0.6003 | |
| GSE29001 | FDX1 | 2230 | 203647_s_at | -0.2948 | 0.3403 | |
| GSE38129 | FDX1 | 2230 | 203647_s_at | -0.2685 | 0.0494 | |
| GSE45670 | FDX1 | 2230 | 203647_s_at | -0.0813 | 0.6193 | |
| GSE53622 | FDX1 | 2230 | 72407 | -1.2048 | 0.0000 | |
| GSE53624 | FDX1 | 2230 | 72407 | -0.9039 | 0.0000 | |
| GSE63941 | FDX1 | 2230 | 203647_s_at | -0.0516 | 0.9029 | |
| GSE77861 | FDX1 | 2230 | 203647_s_at | -0.2986 | 0.4001 | |
| GSE97050 | FDX1 | 2230 | A_33_P3343690 | -0.6955 | 0.1133 | |
| SRP007169 | FDX1 | 2230 | RNAseq | -0.7602 | 0.0662 | |
| SRP008496 | FDX1 | 2230 | RNAseq | -0.4964 | 0.0694 | |
| SRP064894 | FDX1 | 2230 | RNAseq | -0.2941 | 0.0713 | |
| SRP133303 | FDX1 | 2230 | RNAseq | -0.2084 | 0.1738 | |
| SRP159526 | FDX1 | 2230 | RNAseq | -0.3525 | 0.2268 | |
| SRP193095 | FDX1 | 2230 | RNAseq | -0.8392 | 0.0000 | |
| SRP219564 | FDX1 | 2230 | RNAseq | -0.1218 | 0.6830 | |
| TCGA | FDX1 | 2230 | RNAseq | -0.2350 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FDX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FDX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FDX1 | 2230 | 0 | 13 | 17 | |
| GSE20123 | FDX1 | 2230 | 0 | 13 | 17 | |
| GSE43470 | FDX1 | 2230 | 2 | 6 | 35 | |
| GSE46452 | FDX1 | 2230 | 3 | 26 | 30 | |
| GSE47630 | FDX1 | 2230 | 2 | 19 | 19 | |
| GSE54993 | FDX1 | 2230 | 10 | 0 | 60 | |
| GSE54994 | FDX1 | 2230 | 5 | 19 | 29 | |
| GSE60625 | FDX1 | 2230 | 0 | 3 | 8 | |
| GSE74703 | FDX1 | 2230 | 1 | 4 | 31 | |
| GSE74704 | FDX1 | 2230 | 0 | 9 | 11 | |
| TCGA | FDX1 | 2230 | 6 | 47 | 43 |
Total number of gains: 29; Total number of losses: 159; Total Number of normals: 300.
Somatic mutations of FDX1:
Generating mutation plots.
Highly correlated genes for FDX1:
Showing top 20/796 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FDX1 | AIFM2 | 0.78953 | 3 | 0 | 3 |
| FDX1 | CLEC3B | 0.762259 | 3 | 0 | 3 |
| FDX1 | TCEAL1 | 0.760022 | 3 | 0 | 3 |
| FDX1 | F10 | 0.739755 | 3 | 0 | 3 |
| FDX1 | ADAMTS8 | 0.739308 | 3 | 0 | 3 |
| FDX1 | RIC3 | 0.736117 | 3 | 0 | 3 |
| FDX1 | PPP1R3B | 0.72919 | 3 | 0 | 3 |
| FDX1 | TCF21 | 0.727684 | 3 | 0 | 3 |
| FDX1 | RCAN2 | 0.724184 | 3 | 0 | 3 |
| FDX1 | MRPS11 | 0.720392 | 3 | 0 | 3 |
| FDX1 | SORCS1 | 0.718125 | 3 | 0 | 3 |
| FDX1 | DIXDC1 | 0.717772 | 3 | 0 | 3 |
| FDX1 | FBXL17 | 0.716835 | 3 | 0 | 3 |
| FDX1 | TBC1D20 | 0.712426 | 3 | 0 | 3 |
| FDX1 | ALKBH7 | 0.710219 | 3 | 0 | 3 |
| FDX1 | VPS53 | 0.708721 | 3 | 0 | 3 |
| FDX1 | GAS7 | 0.706279 | 3 | 0 | 3 |
| FDX1 | PCMTD1 | 0.705946 | 3 | 0 | 3 |
| FDX1 | CLYBL | 0.705564 | 3 | 0 | 3 |
| FDX1 | AK3 | 0.703019 | 4 | 0 | 4 |
For details and further investigation, click here
