| Full name: MON2 homolog, regulator of endosome-to-Golgi trafficking | Alias Symbol: KIAA1040 | ||
| Type: protein-coding gene | Cytoband: 12q14.1 | ||
| Entrez ID: 23041 | HGNC ID: HGNC:29177 | Ensembl Gene: ENSG00000061987 | OMIM ID: 616822 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MON2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MON2 | 23041 | 212754_s_at | -0.3342 | 0.2537 | |
| GSE20347 | MON2 | 23041 | 212754_s_at | -0.1896 | 0.0631 | |
| GSE23400 | MON2 | 23041 | 212754_s_at | 0.0060 | 0.9204 | |
| GSE26886 | MON2 | 23041 | 212754_s_at | -0.0040 | 0.9887 | |
| GSE29001 | MON2 | 23041 | 212754_s_at | -0.2221 | 0.4318 | |
| GSE38129 | MON2 | 23041 | 212754_s_at | -0.1344 | 0.2090 | |
| GSE45670 | MON2 | 23041 | 212754_s_at | -0.0861 | 0.4013 | |
| GSE53622 | MON2 | 23041 | 28892 | -0.1438 | 0.0073 | |
| GSE53624 | MON2 | 23041 | 28892 | -0.0188 | 0.7591 | |
| GSE63941 | MON2 | 23041 | 212754_s_at | -0.5167 | 0.1237 | |
| GSE77861 | MON2 | 23041 | 212754_s_at | -0.0624 | 0.7954 | |
| GSE97050 | MON2 | 23041 | A_33_P3346937 | 0.2183 | 0.2709 | |
| SRP007169 | MON2 | 23041 | RNAseq | 0.1524 | 0.6530 | |
| SRP008496 | MON2 | 23041 | RNAseq | 0.2264 | 0.2222 | |
| SRP064894 | MON2 | 23041 | RNAseq | -0.5646 | 0.0181 | |
| SRP133303 | MON2 | 23041 | RNAseq | -0.1507 | 0.1383 | |
| SRP159526 | MON2 | 23041 | RNAseq | -0.7019 | 0.0002 | |
| SRP193095 | MON2 | 23041 | RNAseq | -0.3576 | 0.0000 | |
| SRP219564 | MON2 | 23041 | RNAseq | -0.3618 | 0.2628 | |
| TCGA | MON2 | 23041 | RNAseq | -0.1904 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MON2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MON2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MON2 | 23041 | 3 | 1 | 26 | |
| GSE20123 | MON2 | 23041 | 3 | 1 | 26 | |
| GSE43470 | MON2 | 23041 | 4 | 0 | 39 | |
| GSE46452 | MON2 | 23041 | 9 | 0 | 50 | |
| GSE47630 | MON2 | 23041 | 10 | 2 | 28 | |
| GSE54993 | MON2 | 23041 | 0 | 5 | 65 | |
| GSE54994 | MON2 | 23041 | 5 | 1 | 47 | |
| GSE60625 | MON2 | 23041 | 0 | 0 | 11 | |
| GSE74703 | MON2 | 23041 | 4 | 0 | 32 | |
| GSE74704 | MON2 | 23041 | 2 | 1 | 17 | |
| TCGA | MON2 | 23041 | 16 | 9 | 71 |
Total number of gains: 56; Total number of losses: 20; Total Number of normals: 412.
Somatic mutations of MON2:
Generating mutation plots.
Highly correlated genes for MON2:
Showing top 20/436 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MON2 | SLC10A7 | 0.770524 | 3 | 0 | 3 |
| MON2 | VPS53 | 0.719939 | 3 | 0 | 3 |
| MON2 | GPR157 | 0.686369 | 3 | 0 | 3 |
| MON2 | IL10RB | 0.68294 | 4 | 0 | 4 |
| MON2 | RNLS | 0.679233 | 3 | 0 | 3 |
| MON2 | MIR34A | 0.678186 | 3 | 0 | 3 |
| MON2 | RHBDL2 | 0.676786 | 3 | 0 | 3 |
| MON2 | ASCC3 | 0.675884 | 3 | 0 | 3 |
| MON2 | RAB9A | 0.674352 | 4 | 0 | 4 |
| MON2 | ATP6V1G1 | 0.670321 | 5 | 0 | 5 |
| MON2 | UBQLN1 | 0.667979 | 3 | 0 | 3 |
| MON2 | TEAD1 | 0.661719 | 3 | 0 | 3 |
| MON2 | ATMIN | 0.658734 | 6 | 0 | 4 |
| MON2 | COPB2 | 0.657576 | 4 | 0 | 3 |
| MON2 | DUOX1 | 0.655226 | 4 | 0 | 3 |
| MON2 | STAU2 | 0.654123 | 5 | 0 | 4 |
| MON2 | RBAK | 0.653298 | 4 | 0 | 4 |
| MON2 | MTPN | 0.653206 | 5 | 0 | 4 |
| MON2 | ARHGEF3 | 0.650645 | 5 | 0 | 4 |
| MON2 | PDZD8 | 0.649082 | 5 | 0 | 4 |
For details and further investigation, click here
