KDM5B

 

Full name: lysine demethylase 5B Alias Symbol: RBBP2H1A|PLU-1|CT31|PPP1R98
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 10765 HGNC ID: HGNC:18039 Ensembl Gene: ENSG00000117139 OMIM ID: 605393
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KDM5B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KDM5B 10765 211202_s_at 0.2222 0.7387
GSE20347 KDM5B 10765 211202_s_at -0.2705 0.2244
GSE23400 KDM5B 10765 211202_s_at 0.1169 0.1768
GSE26886 KDM5B 10765 211202_s_at -0.2388 0.4350
GSE29001 KDM5B 10765 201548_s_at 0.2400 0.4643
GSE38129 KDM5B 10765 211202_s_at 0.0780 0.7429
GSE45670 KDM5B 10765 211202_s_at 0.1739 0.2543
GSE53622 KDM5B 10765 14386 0.3911 0.0000
GSE53624 KDM5B 10765 21954 0.2696 0.0020
GSE63941 KDM5B 10765 211202_s_at -0.1666 0.7381
GSE77861 KDM5B 10765 211202_s_at 0.2004 0.5418
GSE97050 KDM5B 10765 A_33_P3276455 0.2975 0.2156
SRP007169 KDM5B 10765 RNAseq -0.1208 0.7148
SRP008496 KDM5B 10765 RNAseq -0.2286 0.2066
SRP064894 KDM5B 10765 RNAseq -0.1123 0.6191
SRP133303 KDM5B 10765 RNAseq 0.3196 0.0884
SRP159526 KDM5B 10765 RNAseq 0.2512 0.1309
SRP193095 KDM5B 10765 RNAseq -0.0865 0.5478
SRP219564 KDM5B 10765 RNAseq -0.2536 0.5562
TCGA KDM5B 10765 RNAseq 0.1831 0.0007

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KDM5B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KDM5B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KDM5B 10765 11 0 19
GSE20123 KDM5B 10765 11 0 19
GSE43470 KDM5B 10765 6 0 37
GSE46452 KDM5B 10765 3 1 55
GSE47630 KDM5B 10765 14 0 26
GSE54993 KDM5B 10765 0 6 64
GSE54994 KDM5B 10765 15 0 38
GSE60625 KDM5B 10765 0 0 11
GSE74703 KDM5B 10765 6 0 30
GSE74704 KDM5B 10765 5 0 15
TCGA KDM5B 10765 43 4 49

Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.  

 

Somatic mutations of KDM5B:

 

Generating mutation plots.

 

Highly correlated genes for KDM5B:

 

Showing top 20/355 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KDM5BTMEM167A0.78889303
KDM5BSEC61B0.765513303
KDM5BSRP90.751782303
KDM5BZNF7000.747001303
KDM5BPOLDIP20.738725303
KDM5BMGAT4B0.737974303
KDM5BSLC10A70.737861303
KDM5BWDR410.734499303
KDM5BPIGC0.719334303
KDM5BASF1A0.716427303
KDM5BMCMBP0.716269303
KDM5BNUP540.716147303
KDM5BVPS530.713275303
KDM5BZNF5570.711756404
KDM5BTRUB10.70626303
KDM5BTHAP110.700088303
KDM5BDCAF130.69879303
KDM5BLNX20.69815303
KDM5BMRPL300.694156303
KDM5BROBO10.688824303

For details and further investigation, click here