| Full name: oxysterol binding protein like 8 | Alias Symbol: OSBP10|ORP8|MST120|MSTP120 | ||
| Type: protein-coding gene | Cytoband: 12q14 | ||
| Entrez ID: 114882 | HGNC ID: HGNC:16396 | Ensembl Gene: ENSG00000091039 | OMIM ID: 606736 |
| Drug and gene relationship at DGIdb | |||
Expression of OSBPL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBPL8 | 114882 | 212582_at | -0.2244 | 0.6472 | |
| GSE20347 | OSBPL8 | 114882 | 212582_at | -0.4459 | 0.0078 | |
| GSE23400 | OSBPL8 | 114882 | 212582_at | -0.1157 | 0.4283 | |
| GSE26886 | OSBPL8 | 114882 | 212582_at | -1.0908 | 0.0001 | |
| GSE29001 | OSBPL8 | 114882 | 212585_at | -0.5382 | 0.1319 | |
| GSE38129 | OSBPL8 | 114882 | 212582_at | -0.4472 | 0.1063 | |
| GSE45670 | OSBPL8 | 114882 | 212582_at | -0.5141 | 0.0209 | |
| GSE53622 | OSBPL8 | 114882 | 8786 | -0.2685 | 0.0012 | |
| GSE53624 | OSBPL8 | 114882 | 8786 | -0.5475 | 0.0000 | |
| GSE63941 | OSBPL8 | 114882 | 212582_at | -1.2156 | 0.0642 | |
| GSE77861 | OSBPL8 | 114882 | 212582_at | -0.2546 | 0.7313 | |
| GSE97050 | OSBPL8 | 114882 | A_33_P3254191 | 0.1590 | 0.5560 | |
| SRP007169 | OSBPL8 | 114882 | RNAseq | -0.4770 | 0.0973 | |
| SRP008496 | OSBPL8 | 114882 | RNAseq | -0.3163 | 0.1234 | |
| SRP064894 | OSBPL8 | 114882 | RNAseq | -0.3039 | 0.3137 | |
| SRP133303 | OSBPL8 | 114882 | RNAseq | -0.0726 | 0.6413 | |
| SRP159526 | OSBPL8 | 114882 | RNAseq | -0.7524 | 0.0010 | |
| SRP193095 | OSBPL8 | 114882 | RNAseq | -0.5773 | 0.0000 | |
| SRP219564 | OSBPL8 | 114882 | RNAseq | -0.5861 | 0.0506 | |
| TCGA | OSBPL8 | 114882 | RNAseq | 0.0192 | 0.6890 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by OSBPL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBPL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBPL8 | 114882 | 3 | 4 | 23 | |
| GSE20123 | OSBPL8 | 114882 | 3 | 4 | 23 | |
| GSE43470 | OSBPL8 | 114882 | 3 | 1 | 39 | |
| GSE46452 | OSBPL8 | 114882 | 8 | 1 | 50 | |
| GSE47630 | OSBPL8 | 114882 | 10 | 1 | 29 | |
| GSE54993 | OSBPL8 | 114882 | 0 | 5 | 65 | |
| GSE54994 | OSBPL8 | 114882 | 5 | 2 | 46 | |
| GSE60625 | OSBPL8 | 114882 | 0 | 0 | 11 | |
| GSE74703 | OSBPL8 | 114882 | 3 | 1 | 32 | |
| GSE74704 | OSBPL8 | 114882 | 2 | 2 | 16 | |
| TCGA | OSBPL8 | 114882 | 14 | 15 | 67 |
Total number of gains: 51; Total number of losses: 36; Total Number of normals: 401.
Somatic mutations of OSBPL8:
Generating mutation plots.
Highly correlated genes for OSBPL8:
Showing top 20/767 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBPL8 | ZNF681 | 0.806829 | 4 | 0 | 4 |
| OSBPL8 | STK38 | 0.787436 | 3 | 0 | 3 |
| OSBPL8 | PLEKHA7 | 0.778401 | 3 | 0 | 3 |
| OSBPL8 | TMEM120A | 0.778199 | 3 | 0 | 3 |
| OSBPL8 | ZNF436 | 0.775274 | 4 | 0 | 4 |
| OSBPL8 | VPS53 | 0.771116 | 3 | 0 | 3 |
| OSBPL8 | ESYT2 | 0.770132 | 3 | 0 | 3 |
| OSBPL8 | PRKAR2A | 0.767 | 5 | 0 | 5 |
| OSBPL8 | NIPSNAP3A | 0.756788 | 3 | 0 | 3 |
| OSBPL8 | FRMD6 | 0.749653 | 4 | 0 | 4 |
| OSBPL8 | THAP2 | 0.745071 | 3 | 0 | 3 |
| OSBPL8 | ZCCHC10 | 0.740238 | 3 | 0 | 3 |
| OSBPL8 | DNAJB6 | 0.738767 | 3 | 0 | 3 |
| OSBPL8 | TPD52L2 | 0.737683 | 3 | 0 | 3 |
| OSBPL8 | PRPF38A | 0.73415 | 3 | 0 | 3 |
| OSBPL8 | SPIN4 | 0.729521 | 4 | 0 | 4 |
| OSBPL8 | CANT1 | 0.728719 | 3 | 0 | 3 |
| OSBPL8 | CSNK1A1 | 0.726826 | 4 | 0 | 3 |
| OSBPL8 | PTCD2 | 0.723889 | 3 | 0 | 3 |
| OSBPL8 | TBK1 | 0.719216 | 5 | 0 | 5 |
For details and further investigation, click here
