| Full name: zinc finger DHHC-type containing 21 | Alias Symbol: HSPC097|DNZ1|DHHC21 | ||
| Type: protein-coding gene | Cytoband: 9p22.3 | ||
| Entrez ID: 340481 | HGNC ID: HGNC:20750 | Ensembl Gene: ENSG00000175893 | OMIM ID: 614605 |
| Drug and gene relationship at DGIdb | |||
Expression of ZDHHC21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZDHHC21 | 340481 | 235068_at | -1.0752 | 0.1193 | |
| GSE26886 | ZDHHC21 | 340481 | 235068_at | -2.8330 | 0.0000 | |
| GSE45670 | ZDHHC21 | 340481 | 235068_at | -0.1387 | 0.6568 | |
| GSE53622 | ZDHHC21 | 340481 | 4031 | -0.8845 | 0.0000 | |
| GSE53624 | ZDHHC21 | 340481 | 4031 | -0.9216 | 0.0000 | |
| GSE63941 | ZDHHC21 | 340481 | 241946_at | -0.1626 | 0.8805 | |
| GSE77861 | ZDHHC21 | 340481 | 235068_at | -0.9600 | 0.0411 | |
| GSE97050 | ZDHHC21 | 340481 | A_24_P374427 | -0.2662 | 0.3225 | |
| SRP007169 | ZDHHC21 | 340481 | RNAseq | -2.1591 | 0.0000 | |
| SRP008496 | ZDHHC21 | 340481 | RNAseq | -1.8362 | 0.0000 | |
| SRP064894 | ZDHHC21 | 340481 | RNAseq | -1.2991 | 0.0000 | |
| SRP133303 | ZDHHC21 | 340481 | RNAseq | -0.7052 | 0.0213 | |
| SRP159526 | ZDHHC21 | 340481 | RNAseq | -1.4843 | 0.0000 | |
| SRP193095 | ZDHHC21 | 340481 | RNAseq | -1.5759 | 0.0000 | |
| SRP219564 | ZDHHC21 | 340481 | RNAseq | -1.5091 | 0.0100 | |
| TCGA | ZDHHC21 | 340481 | RNAseq | -0.1331 | 0.2195 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ZDHHC21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZDHHC21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZDHHC21 | 340481 | 2 | 16 | 12 | |
| GSE20123 | ZDHHC21 | 340481 | 2 | 16 | 12 | |
| GSE43470 | ZDHHC21 | 340481 | 5 | 11 | 27 | |
| GSE46452 | ZDHHC21 | 340481 | 2 | 23 | 34 | |
| GSE47630 | ZDHHC21 | 340481 | 4 | 26 | 10 | |
| GSE54993 | ZDHHC21 | 340481 | 6 | 3 | 61 | |
| GSE54994 | ZDHHC21 | 340481 | 10 | 16 | 27 | |
| GSE60625 | ZDHHC21 | 340481 | 0 | 0 | 11 | |
| GSE74703 | ZDHHC21 | 340481 | 5 | 8 | 23 | |
| GSE74704 | ZDHHC21 | 340481 | 0 | 13 | 7 | |
| TCGA | ZDHHC21 | 340481 | 14 | 50 | 32 |
Total number of gains: 50; Total number of losses: 182; Total Number of normals: 256.
Somatic mutations of ZDHHC21:
Generating mutation plots.
Highly correlated genes for ZDHHC21:
Showing top 20/1471 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZDHHC21 | BACH1 | 0.844224 | 4 | 0 | 4 |
| ZDHHC21 | MCTS1 | 0.826694 | 3 | 0 | 3 |
| ZDHHC21 | GBP6 | 0.803688 | 4 | 0 | 4 |
| ZDHHC21 | RNF146 | 0.799639 | 3 | 0 | 3 |
| ZDHHC21 | SLC25A46 | 0.797652 | 3 | 0 | 3 |
| ZDHHC21 | C18orf25 | 0.793975 | 7 | 0 | 7 |
| ZDHHC21 | ZNF92 | 0.792769 | 3 | 0 | 3 |
| ZDHHC21 | NCKAP1 | 0.792058 | 3 | 0 | 3 |
| ZDHHC21 | PLEKHM1 | 0.788906 | 7 | 0 | 7 |
| ZDHHC21 | VSIG10L | 0.785039 | 6 | 0 | 6 |
| ZDHHC21 | CRYBG3 | 0.782354 | 4 | 0 | 4 |
| ZDHHC21 | TTC22 | 0.780188 | 6 | 0 | 6 |
| ZDHHC21 | MPZL3 | 0.775547 | 7 | 0 | 7 |
| ZDHHC21 | VPS4B | 0.774998 | 7 | 0 | 6 |
| ZDHHC21 | SLC16A6 | 0.774916 | 7 | 0 | 7 |
| ZDHHC21 | SPNS2 | 0.774142 | 5 | 0 | 5 |
| ZDHHC21 | LYSMD3 | 0.774025 | 4 | 0 | 4 |
| ZDHHC21 | SASH1 | 0.773189 | 7 | 0 | 7 |
| ZDHHC21 | FCHO2 | 0.769752 | 7 | 0 | 7 |
| ZDHHC21 | EMP1 | 0.769206 | 6 | 0 | 6 |
For details and further investigation, click here
