| Full name: guanylate kinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q42.13 | ||
| Entrez ID: 2987 | HGNC ID: HGNC:4693 | Ensembl Gene: ENSG00000143774 | OMIM ID: 139270 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GUK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GUK1 | 2987 | 200075_s_at | -0.0558 | 0.8823 | |
| GSE20347 | GUK1 | 2987 | 200075_s_at | -0.8897 | 0.0000 | |
| GSE23400 | GUK1 | 2987 | 200075_s_at | -0.4219 | 0.0000 | |
| GSE26886 | GUK1 | 2987 | 200075_s_at | -0.7909 | 0.0019 | |
| GSE29001 | GUK1 | 2987 | 200075_s_at | -0.9074 | 0.0316 | |
| GSE38129 | GUK1 | 2987 | 200075_s_at | -0.5738 | 0.0001 | |
| GSE45670 | GUK1 | 2987 | 200075_s_at | -0.2290 | 0.1728 | |
| GSE53622 | GUK1 | 2987 | 15400 | -0.8116 | 0.0000 | |
| GSE53624 | GUK1 | 2987 | 15400 | -0.4603 | 0.0000 | |
| GSE63941 | GUK1 | 2987 | 200075_s_at | -0.8723 | 0.1102 | |
| GSE77861 | GUK1 | 2987 | 200075_s_at | -0.6726 | 0.0023 | |
| GSE97050 | GUK1 | 2987 | A_23_P201097 | -0.3340 | 0.2513 | |
| SRP007169 | GUK1 | 2987 | RNAseq | -2.0680 | 0.0000 | |
| SRP008496 | GUK1 | 2987 | RNAseq | -1.7610 | 0.0000 | |
| SRP064894 | GUK1 | 2987 | RNAseq | -0.1717 | 0.5931 | |
| SRP133303 | GUK1 | 2987 | RNAseq | -0.4333 | 0.0006 | |
| SRP159526 | GUK1 | 2987 | RNAseq | -0.9400 | 0.0009 | |
| SRP193095 | GUK1 | 2987 | RNAseq | -0.8821 | 0.0000 | |
| SRP219564 | GUK1 | 2987 | RNAseq | -0.3070 | 0.1882 | |
| TCGA | GUK1 | 2987 | RNAseq | -0.0583 | 0.2240 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GUK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GUK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GUK1 | 2987 | 11 | 0 | 19 | |
| GSE20123 | GUK1 | 2987 | 11 | 0 | 19 | |
| GSE43470 | GUK1 | 2987 | 7 | 1 | 35 | |
| GSE46452 | GUK1 | 2987 | 4 | 2 | 53 | |
| GSE47630 | GUK1 | 2987 | 15 | 0 | 25 | |
| GSE54993 | GUK1 | 2987 | 0 | 6 | 64 | |
| GSE54994 | GUK1 | 2987 | 17 | 0 | 36 | |
| GSE60625 | GUK1 | 2987 | 0 | 0 | 11 | |
| GSE74703 | GUK1 | 2987 | 7 | 1 | 28 | |
| GSE74704 | GUK1 | 2987 | 5 | 0 | 15 | |
| TCGA | GUK1 | 2987 | 45 | 2 | 49 |
Total number of gains: 122; Total number of losses: 12; Total Number of normals: 354.
Somatic mutations of GUK1:
Generating mutation plots.
Highly correlated genes for GUK1:
Showing top 20/1391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GUK1 | ZCCHC9 | 0.794915 | 3 | 0 | 3 |
| GUK1 | AVP | 0.783442 | 3 | 0 | 3 |
| GUK1 | CIAPIN1 | 0.766666 | 3 | 0 | 3 |
| GUK1 | TMEM167A | 0.747254 | 3 | 0 | 3 |
| GUK1 | CD47 | 0.740912 | 3 | 0 | 3 |
| GUK1 | SLC35B3 | 0.738332 | 3 | 0 | 3 |
| GUK1 | VPS53 | 0.726899 | 3 | 0 | 3 |
| GUK1 | MTMR10 | 0.720584 | 4 | 0 | 3 |
| GUK1 | HERPUD1 | 0.720548 | 3 | 0 | 3 |
| GUK1 | NDUFA13 | 0.718635 | 7 | 0 | 6 |
| GUK1 | PRELID1 | 0.717276 | 4 | 0 | 3 |
| GUK1 | CCDC12 | 0.716765 | 5 | 0 | 4 |
| GUK1 | PDCD6IP | 0.716166 | 10 | 0 | 10 |
| GUK1 | ZNF862 | 0.715895 | 3 | 0 | 3 |
| GUK1 | GMPPB | 0.71478 | 3 | 0 | 3 |
| GUK1 | NPRL2 | 0.7138 | 5 | 0 | 4 |
| GUK1 | ABHD14B | 0.710638 | 4 | 0 | 4 |
| GUK1 | GPR108 | 0.710478 | 4 | 0 | 4 |
| GUK1 | GRN | 0.710334 | 11 | 0 | 10 |
| GUK1 | PRADC1 | 0.709411 | 6 | 0 | 6 |
For details and further investigation, click here
