| Full name: von Willebrand factor C and EGF domains | Alias Symbol: URG11|FLJ32009|VWC1 | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 220001 | HGNC ID: HGNC:26487 | Ensembl Gene: ENSG00000167992 | OMIM ID: 611115 |
| Drug and gene relationship at DGIdb | |||
Expression of VWCE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VWCE | 220001 | 242957_at | -0.1326 | 0.7294 | |
| GSE26886 | VWCE | 220001 | 242957_at | 0.4204 | 0.0706 | |
| GSE45670 | VWCE | 220001 | 242957_at | -0.0283 | 0.7824 | |
| GSE53622 | VWCE | 220001 | 85919 | -0.5224 | 0.0001 | |
| GSE53624 | VWCE | 220001 | 85919 | -0.4927 | 0.0000 | |
| GSE63941 | VWCE | 220001 | 242957_at | -1.0985 | 0.0004 | |
| GSE77861 | VWCE | 220001 | 242957_at | -0.1432 | 0.3143 | |
| GSE97050 | VWCE | 220001 | A_33_P3211238 | -0.8958 | 0.1556 | |
| SRP133303 | VWCE | 220001 | RNAseq | -1.2639 | 0.0007 | |
| SRP159526 | VWCE | 220001 | RNAseq | -0.1431 | 0.8322 | |
| SRP219564 | VWCE | 220001 | RNAseq | -0.9395 | 0.0020 | |
| TCGA | VWCE | 220001 | RNAseq | -0.2920 | 0.3425 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by VWCE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VWCE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VWCE | 220001 | 4 | 5 | 21 | |
| GSE20123 | VWCE | 220001 | 4 | 5 | 21 | |
| GSE43470 | VWCE | 220001 | 2 | 6 | 35 | |
| GSE46452 | VWCE | 220001 | 8 | 4 | 47 | |
| GSE47630 | VWCE | 220001 | 3 | 8 | 29 | |
| GSE54993 | VWCE | 220001 | 3 | 0 | 67 | |
| GSE54994 | VWCE | 220001 | 5 | 5 | 43 | |
| GSE60625 | VWCE | 220001 | 0 | 3 | 8 | |
| GSE74703 | VWCE | 220001 | 2 | 3 | 31 | |
| GSE74704 | VWCE | 220001 | 3 | 3 | 14 | |
| TCGA | VWCE | 220001 | 15 | 10 | 71 |
Total number of gains: 49; Total number of losses: 52; Total Number of normals: 387.
Somatic mutations of VWCE:
Generating mutation plots.
Highly correlated genes for VWCE:
Showing top 20/112 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VWCE | DPPA4 | 0.743199 | 3 | 0 | 3 |
| VWCE | OR3A2 | 0.69133 | 3 | 0 | 3 |
| VWCE | AQP5 | 0.687968 | 3 | 0 | 3 |
| VWCE | ATF5 | 0.684678 | 3 | 0 | 3 |
| VWCE | CRYBA1 | 0.67222 | 3 | 0 | 3 |
| VWCE | AMN | 0.670721 | 3 | 0 | 3 |
| VWCE | BPIFB6 | 0.668775 | 3 | 0 | 3 |
| VWCE | MAP1A | 0.668726 | 3 | 0 | 3 |
| VWCE | BPIFB1 | 0.667627 | 3 | 0 | 3 |
| VWCE | CD1E | 0.667395 | 3 | 0 | 3 |
| VWCE | L3MBTL1 | 0.662478 | 3 | 0 | 3 |
| VWCE | ST6GALNAC6 | 0.66224 | 3 | 0 | 3 |
| VWCE | KLK15 | 0.656278 | 3 | 0 | 3 |
| VWCE | RSPO1 | 0.656268 | 3 | 0 | 3 |
| VWCE | RNF31 | 0.653567 | 4 | 0 | 3 |
| VWCE | NEU4 | 0.647799 | 3 | 0 | 3 |
| VWCE | PRH2 | 0.643108 | 3 | 0 | 3 |
| VWCE | ADH1B | 0.641938 | 3 | 0 | 3 |
| VWCE | HPN | 0.638953 | 3 | 0 | 3 |
| VWCE | NSMF | 0.637405 | 3 | 0 | 3 |
For details and further investigation, click here
