| Full name: hepsin | Alias Symbol: TMPRSS1 | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 3249 | HGNC ID: HGNC:5155 | Ensembl Gene: ENSG00000105707 | OMIM ID: 142440 |
| Drug and gene relationship at DGIdb | |||
Expression of HPN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPN | 3249 | 204934_s_at | 0.1304 | 0.5940 | |
| GSE20347 | HPN | 3249 | 204934_s_at | -0.1087 | 0.2811 | |
| GSE23400 | HPN | 3249 | 204934_s_at | -0.1096 | 0.0067 | |
| GSE26886 | HPN | 3249 | 204934_s_at | 0.1882 | 0.1730 | |
| GSE29001 | HPN | 3249 | 204934_s_at | 0.0716 | 0.7475 | |
| GSE38129 | HPN | 3249 | 204934_s_at | -0.0083 | 0.9677 | |
| GSE45670 | HPN | 3249 | 204934_s_at | 0.1497 | 0.2583 | |
| GSE53622 | HPN | 3249 | 75630 | 0.3122 | 0.2592 | |
| GSE53624 | HPN | 3249 | 75630 | 0.4320 | 0.0409 | |
| GSE63941 | HPN | 3249 | 204934_s_at | -0.2721 | 0.4379 | |
| GSE77861 | HPN | 3249 | 204934_s_at | 0.0084 | 0.9476 | |
| TCGA | HPN | 3249 | RNAseq | -3.1835 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HPN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPN | 3249 | 6 | 5 | 19 | |
| GSE20123 | HPN | 3249 | 6 | 4 | 20 | |
| GSE43470 | HPN | 3249 | 4 | 7 | 32 | |
| GSE46452 | HPN | 3249 | 48 | 1 | 10 | |
| GSE47630 | HPN | 3249 | 8 | 6 | 26 | |
| GSE54993 | HPN | 3249 | 17 | 3 | 50 | |
| GSE54994 | HPN | 3249 | 9 | 9 | 35 | |
| GSE60625 | HPN | 3249 | 9 | 0 | 2 | |
| GSE74703 | HPN | 3249 | 4 | 4 | 28 | |
| GSE74704 | HPN | 3249 | 6 | 2 | 12 | |
| TCGA | HPN | 3249 | 21 | 11 | 64 |
Total number of gains: 138; Total number of losses: 52; Total Number of normals: 298.
Somatic mutations of HPN:
Generating mutation plots.
Highly correlated genes for HPN:
Showing top 20/194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPN | APOL2 | 0.704421 | 4 | 0 | 4 |
| HPN | MEIS3 | 0.685064 | 3 | 0 | 3 |
| HPN | SH2B2 | 0.648987 | 3 | 0 | 3 |
| HPN | C9orf64 | 0.644494 | 3 | 0 | 3 |
| HPN | ZNF696 | 0.640117 | 4 | 0 | 3 |
| HPN | VWCE | 0.638953 | 3 | 0 | 3 |
| HPN | CDK20 | 0.637689 | 3 | 0 | 3 |
| HPN | HSD3B7 | 0.636216 | 3 | 0 | 3 |
| HPN | NPTX1 | 0.634367 | 3 | 0 | 3 |
| HPN | LRP5L | 0.631807 | 3 | 0 | 3 |
| HPN | SYT12 | 0.631144 | 3 | 0 | 3 |
| HPN | FAM53A | 0.630593 | 4 | 0 | 3 |
| HPN | RHPN1 | 0.630343 | 3 | 0 | 3 |
| HPN | LIMK1 | 0.625929 | 3 | 0 | 3 |
| HPN | KRT81 | 0.622653 | 5 | 0 | 4 |
| HPN | FCHO1 | 0.616326 | 4 | 0 | 4 |
| HPN | KCNC2 | 0.616178 | 4 | 0 | 3 |
| HPN | OBSCN | 0.613237 | 5 | 0 | 4 |
| HPN | TNK2 | 0.610752 | 5 | 0 | 5 |
| HPN | FBLN7 | 0.610363 | 4 | 0 | 3 |
For details and further investigation, click here
