| Full name: alcohol dehydrogenase 1B (class I), beta polypeptide | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 125 | HGNC ID: HGNC:250 | Ensembl Gene: ENSG00000196616 | OMIM ID: 103720 |
| Drug and gene relationship at DGIdb | |||
Expression of ADH1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADH1B | 125 | 209612_s_at | -4.1705 | 0.0409 | |
| GSE20347 | ADH1B | 125 | 209614_at | -0.1609 | 0.1070 | |
| GSE23400 | ADH1B | 125 | 209612_s_at | -2.3203 | 0.0000 | |
| GSE26886 | ADH1B | 125 | 209614_at | -0.5919 | 0.0199 | |
| GSE29001 | ADH1B | 125 | 209612_s_at | -1.4915 | 0.0002 | |
| GSE38129 | ADH1B | 125 | 209613_s_at | -4.0213 | 0.0000 | |
| GSE45670 | ADH1B | 125 | 209612_s_at | -5.8767 | 0.0000 | |
| GSE53622 | ADH1B | 125 | 61881 | -3.3732 | 0.0000 | |
| GSE53624 | ADH1B | 125 | 61881 | -3.5410 | 0.0000 | |
| GSE63941 | ADH1B | 125 | 209614_at | -3.3801 | 0.0000 | |
| GSE77861 | ADH1B | 125 | 209614_at | -0.0453 | 0.6837 | |
| GSE97050 | ADH1B | 125 | A_33_P3353737 | -0.7732 | 0.1238 | |
| SRP007169 | ADH1B | 125 | RNAseq | -4.7478 | 0.0000 | |
| SRP008496 | ADH1B | 125 | RNAseq | -3.6763 | 0.0001 | |
| SRP064894 | ADH1B | 125 | RNAseq | -2.9087 | 0.0000 | |
| SRP133303 | ADH1B | 125 | RNAseq | -3.6174 | 0.0000 | |
| SRP159526 | ADH1B | 125 | RNAseq | -2.5756 | 0.0055 | |
| SRP193095 | ADH1B | 125 | RNAseq | -1.5243 | 0.0062 | |
| SRP219564 | ADH1B | 125 | RNAseq | -1.6458 | 0.1774 | |
| TCGA | ADH1B | 125 | RNAseq | -2.3350 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by ADH1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADH1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADH1B | 125 | 0 | 12 | 18 | |
| GSE20123 | ADH1B | 125 | 0 | 12 | 18 | |
| GSE43470 | ADH1B | 125 | 0 | 14 | 29 | |
| GSE46452 | ADH1B | 125 | 1 | 36 | 22 | |
| GSE47630 | ADH1B | 125 | 0 | 20 | 20 | |
| GSE54993 | ADH1B | 125 | 9 | 0 | 61 | |
| GSE54994 | ADH1B | 125 | 1 | 11 | 41 | |
| GSE60625 | ADH1B | 125 | 0 | 3 | 8 | |
| GSE74703 | ADH1B | 125 | 0 | 12 | 24 | |
| GSE74704 | ADH1B | 125 | 0 | 6 | 14 | |
| TCGA | ADH1B | 125 | 8 | 41 | 47 |
Total number of gains: 19; Total number of losses: 167; Total Number of normals: 302.
Somatic mutations of ADH1B:
Generating mutation plots.
Highly correlated genes for ADH1B:
Showing top 20/1411 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADH1B | RSPO1 | 0.82705 | 6 | 0 | 6 |
| ADH1B | CLEC3B | 0.825815 | 3 | 0 | 3 |
| ADH1B | PLCXD3 | 0.817918 | 4 | 0 | 4 |
| ADH1B | SYNPO2 | 0.80815 | 6 | 0 | 6 |
| ADH1B | ANGPTL1 | 0.793797 | 7 | 0 | 6 |
| ADH1B | TMEM100 | 0.793647 | 10 | 0 | 9 |
| ADH1B | ABCA8 | 0.790798 | 12 | 0 | 11 |
| ADH1B | RSPO2 | 0.782518 | 3 | 0 | 3 |
| ADH1B | XKR4 | 0.780733 | 5 | 0 | 5 |
| ADH1B | EBF1 | 0.780218 | 6 | 0 | 6 |
| ADH1B | CYP4V2 | 0.780197 | 4 | 0 | 4 |
| ADH1B | RBPMS2 | 0.775632 | 5 | 0 | 5 |
| ADH1B | ZBTB47 | 0.768412 | 3 | 0 | 3 |
| ADH1B | AOC3 | 0.766037 | 10 | 0 | 10 |
| ADH1B | ATP1A2 | 0.76576 | 10 | 0 | 9 |
| ADH1B | PLAC9 | 0.764478 | 6 | 0 | 6 |
| ADH1B | TCF21 | 0.763475 | 10 | 0 | 9 |
| ADH1B | C7 | 0.763441 | 11 | 0 | 11 |
| ADH1B | GFRA1 | 0.762625 | 8 | 0 | 8 |
| ADH1B | FAM13C | 0.76086 | 6 | 0 | 5 |
For details and further investigation, click here
