| Full name: R-spondin 1 | Alias Symbol: FLJ40906|RSPONDIN | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 284654 | HGNC ID: HGNC:21679 | Ensembl Gene: ENSG00000169218 | OMIM ID: 609595 |
| Drug and gene relationship at DGIdb | |||
Expression of RSPO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RSPO1 | 284654 | 241450_at | -0.5046 | 0.0430 | |
| GSE26886 | RSPO1 | 284654 | 241450_at | 0.1658 | 0.2628 | |
| GSE45670 | RSPO1 | 284654 | 241450_at | -0.3816 | 0.0000 | |
| GSE53622 | RSPO1 | 284654 | 140168 | -1.8760 | 0.0000 | |
| GSE53624 | RSPO1 | 284654 | 140168 | -2.3861 | 0.0000 | |
| GSE63941 | RSPO1 | 284654 | 241450_at | -1.0570 | 0.0001 | |
| GSE77861 | RSPO1 | 284654 | 241450_at | -0.1788 | 0.3415 | |
| SRP064894 | RSPO1 | 284654 | RNAseq | -2.7211 | 0.0000 | |
| SRP133303 | RSPO1 | 284654 | RNAseq | -1.8896 | 0.0000 | |
| SRP159526 | RSPO1 | 284654 | RNAseq | -1.4296 | 0.1075 | |
| SRP219564 | RSPO1 | 284654 | RNAseq | -1.1813 | 0.0329 | |
| TCGA | RSPO1 | 284654 | RNAseq | -1.8504 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RSPO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RSPO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RSPO1 | 284654 | 2 | 4 | 24 | |
| GSE20123 | RSPO1 | 284654 | 2 | 3 | 25 | |
| GSE43470 | RSPO1 | 284654 | 7 | 3 | 33 | |
| GSE46452 | RSPO1 | 284654 | 4 | 1 | 54 | |
| GSE47630 | RSPO1 | 284654 | 8 | 3 | 29 | |
| GSE54993 | RSPO1 | 284654 | 1 | 1 | 68 | |
| GSE54994 | RSPO1 | 284654 | 11 | 2 | 40 | |
| GSE60625 | RSPO1 | 284654 | 0 | 0 | 11 | |
| GSE74703 | RSPO1 | 284654 | 6 | 2 | 28 | |
| GSE74704 | RSPO1 | 284654 | 1 | 0 | 19 | |
| TCGA | RSPO1 | 284654 | 12 | 16 | 68 |
Total number of gains: 54; Total number of losses: 35; Total Number of normals: 399.
Somatic mutations of RSPO1:
Generating mutation plots.
Highly correlated genes for RSPO1:
Showing top 20/686 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RSPO1 | ADH1B | 0.82705 | 6 | 0 | 6 |
| RSPO1 | MYRIP | 0.808498 | 4 | 0 | 4 |
| RSPO1 | TMEM100 | 0.796501 | 5 | 0 | 5 |
| RSPO1 | ASPA | 0.796086 | 5 | 0 | 5 |
| RSPO1 | OGN | 0.786631 | 5 | 0 | 5 |
| RSPO1 | LGI1 | 0.781712 | 4 | 0 | 4 |
| RSPO1 | TCF21 | 0.768727 | 5 | 0 | 5 |
| RSPO1 | GREM2 | 0.768517 | 5 | 0 | 5 |
| RSPO1 | CFD | 0.763636 | 6 | 0 | 6 |
| RSPO1 | CXCL12 | 0.763542 | 5 | 0 | 5 |
| RSPO1 | PGM5-AS1 | 0.762 | 3 | 0 | 3 |
| RSPO1 | FHL5 | 0.761077 | 4 | 0 | 4 |
| RSPO1 | PEG3 | 0.753437 | 3 | 0 | 3 |
| RSPO1 | SPAG8 | 0.75134 | 3 | 0 | 3 |
| RSPO1 | DPT | 0.750537 | 6 | 0 | 6 |
| RSPO1 | ATP1A2 | 0.748647 | 4 | 0 | 4 |
| RSPO1 | ABCA6 | 0.74465 | 6 | 0 | 6 |
| RSPO1 | BMX | 0.742107 | 4 | 0 | 4 |
| RSPO1 | ADAMTS8 | 0.739061 | 6 | 0 | 6 |
| RSPO1 | MAMDC2 | 0.738634 | 4 | 0 | 4 |
For details and further investigation, click here
