| Full name: activating transcription factor 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 22809 | HGNC ID: HGNC:790 | Ensembl Gene: ENSG00000169136 | OMIM ID: 606398 |
| Drug and gene relationship at DGIdb | |||
Expression of ATF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATF5 | 22809 | 204998_s_at | 1.1230 | 0.1100 | |
| GSE20347 | ATF5 | 22809 | 204998_s_at | 0.5472 | 0.0001 | |
| GSE23400 | ATF5 | 22809 | 204998_s_at | 0.4783 | 0.0001 | |
| GSE26886 | ATF5 | 22809 | 230938_x_at | 0.1521 | 0.2866 | |
| GSE29001 | ATF5 | 22809 | 204998_s_at | 0.9879 | 0.0274 | |
| GSE38129 | ATF5 | 22809 | 204998_s_at | 0.5794 | 0.0051 | |
| GSE45670 | ATF5 | 22809 | 204998_s_at | 0.5743 | 0.0009 | |
| GSE63941 | ATF5 | 22809 | 204998_s_at | -2.5321 | 0.0020 | |
| GSE77861 | ATF5 | 22809 | 230938_x_at | -0.0047 | 0.9796 | |
| GSE97050 | ATF5 | 22809 | A_23_P119337 | 0.1231 | 0.6793 | |
| SRP007169 | ATF5 | 22809 | RNAseq | 0.7585 | 0.1700 | |
| SRP008496 | ATF5 | 22809 | RNAseq | 0.6833 | 0.0562 | |
| SRP064894 | ATF5 | 22809 | RNAseq | 0.9268 | 0.0001 | |
| SRP133303 | ATF5 | 22809 | RNAseq | 0.9475 | 0.0000 | |
| SRP159526 | ATF5 | 22809 | RNAseq | 1.9344 | 0.0001 | |
| SRP193095 | ATF5 | 22809 | RNAseq | 0.5947 | 0.0110 | |
| SRP219564 | ATF5 | 22809 | RNAseq | 0.6106 | 0.2162 | |
| TCGA | ATF5 | 22809 | RNAseq | 0.1467 | 0.0969 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ATF5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ATF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATF5 | 22809 | 4 | 4 | 22 | |
| GSE20123 | ATF5 | 22809 | 4 | 3 | 23 | |
| GSE43470 | ATF5 | 22809 | 5 | 11 | 27 | |
| GSE46452 | ATF5 | 22809 | 45 | 1 | 13 | |
| GSE47630 | ATF5 | 22809 | 10 | 6 | 24 | |
| GSE54993 | ATF5 | 22809 | 17 | 4 | 49 | |
| GSE54994 | ATF5 | 22809 | 4 | 14 | 35 | |
| GSE60625 | ATF5 | 22809 | 9 | 0 | 2 | |
| GSE74703 | ATF5 | 22809 | 5 | 7 | 24 | |
| GSE74704 | ATF5 | 22809 | 4 | 1 | 15 | |
| TCGA | ATF5 | 22809 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of ATF5:
Generating mutation plots.
Highly correlated genes for ATF5:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATF5 | BIRC7 | 0.711197 | 3 | 0 | 3 |
| ATF5 | GAS6-AS1 | 0.690246 | 3 | 0 | 3 |
| ATF5 | NEB | 0.687876 | 3 | 0 | 3 |
| ATF5 | FOXS1 | 0.685253 | 3 | 0 | 3 |
| ATF5 | VWCE | 0.684678 | 3 | 0 | 3 |
| ATF5 | AAK1 | 0.677785 | 4 | 0 | 4 |
| ATF5 | BARX1 | 0.673551 | 3 | 0 | 3 |
| ATF5 | EVC | 0.666099 | 5 | 0 | 4 |
| ATF5 | ZNF579 | 0.66566 | 4 | 0 | 3 |
| ATF5 | ATR | 0.661357 | 3 | 0 | 3 |
| ATF5 | SLC26A11 | 0.657568 | 3 | 0 | 3 |
| ATF5 | FAM71E1 | 0.656876 | 3 | 0 | 3 |
| ATF5 | COL6A1 | 0.656075 | 5 | 0 | 5 |
| ATF5 | DENND4B | 0.654115 | 6 | 0 | 4 |
| ATF5 | RRS1 | 0.652169 | 4 | 0 | 4 |
| ATF5 | AEBP1 | 0.651985 | 6 | 0 | 5 |
| ATF5 | LPCAT1 | 0.650625 | 6 | 0 | 6 |
| ATF5 | CCDC78 | 0.649262 | 3 | 0 | 3 |
| ATF5 | RBM12B | 0.648004 | 4 | 0 | 4 |
| ATF5 | GATA6 | 0.647301 | 4 | 0 | 3 |
For details and further investigation, click here
