| Full name: Rho guanine nucleotide exchange factor 1 | Alias Symbol: P115-RHOGEF|SUB1.5|LBCL2 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 9138 | HGNC ID: HGNC:681 | Ensembl Gene: ENSG00000076928 | OMIM ID: 601855 |
| Drug and gene relationship at DGIdb | |||
ARHGEF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction | |
| hsa04611 | Platelet activation | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05205 | Proteoglycans in cancer |
Expression of ARHGEF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF1 | 9138 | 1560445_x_at | 0.2039 | 0.7192 | |
| GSE26886 | ARHGEF1 | 9138 | 1560445_x_at | 0.0179 | 0.9456 | |
| GSE45670 | ARHGEF1 | 9138 | 1560445_x_at | 0.1855 | 0.0655 | |
| GSE53622 | ARHGEF1 | 9138 | 85404 | 0.3181 | 0.0000 | |
| GSE53624 | ARHGEF1 | 9138 | 85404 | 0.4467 | 0.0000 | |
| GSE63941 | ARHGEF1 | 9138 | 1560445_x_at | -0.2481 | 0.1876 | |
| GSE77861 | ARHGEF1 | 9138 | 1560445_x_at | 0.3333 | 0.1971 | |
| GSE97050 | ARHGEF1 | 9138 | A_33_P3292864 | -0.1796 | 0.4174 | |
| SRP007169 | ARHGEF1 | 9138 | RNAseq | 0.1498 | 0.6623 | |
| SRP008496 | ARHGEF1 | 9138 | RNAseq | 0.3887 | 0.0750 | |
| SRP064894 | ARHGEF1 | 9138 | RNAseq | 0.8178 | 0.0000 | |
| SRP133303 | ARHGEF1 | 9138 | RNAseq | 0.0369 | 0.8481 | |
| SRP159526 | ARHGEF1 | 9138 | RNAseq | 0.0257 | 0.9101 | |
| SRP193095 | ARHGEF1 | 9138 | RNAseq | 0.7198 | 0.0007 | |
| SRP219564 | ARHGEF1 | 9138 | RNAseq | 0.5506 | 0.0547 | |
| TCGA | ARHGEF1 | 9138 | RNAseq | 0.0723 | 0.1339 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF1 | 9138 | 4 | 4 | 22 | |
| GSE20123 | ARHGEF1 | 9138 | 4 | 3 | 23 | |
| GSE43470 | ARHGEF1 | 9138 | 3 | 11 | 29 | |
| GSE46452 | ARHGEF1 | 9138 | 47 | 1 | 11 | |
| GSE47630 | ARHGEF1 | 9138 | 8 | 6 | 26 | |
| GSE54993 | ARHGEF1 | 9138 | 17 | 4 | 49 | |
| GSE54994 | ARHGEF1 | 9138 | 7 | 12 | 34 | |
| GSE60625 | ARHGEF1 | 9138 | 9 | 0 | 2 | |
| GSE74703 | ARHGEF1 | 9138 | 3 | 7 | 26 | |
| GSE74704 | ARHGEF1 | 9138 | 4 | 1 | 15 | |
| TCGA | ARHGEF1 | 9138 | 14 | 15 | 67 |
Total number of gains: 120; Total number of losses: 64; Total Number of normals: 304.
Somatic mutations of ARHGEF1:
Generating mutation plots.
Highly correlated genes for ARHGEF1:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF1 | TSR1 | 0.821019 | 3 | 0 | 3 |
| ARHGEF1 | FBXW12 | 0.815393 | 5 | 0 | 5 |
| ARHGEF1 | SLC22A3 | 0.800275 | 5 | 0 | 5 |
| ARHGEF1 | CCDC152 | 0.796611 | 6 | 0 | 6 |
| ARHGEF1 | CDK13 | 0.794186 | 6 | 0 | 6 |
| ARHGEF1 | ZNF692 | 0.781585 | 3 | 0 | 3 |
| ARHGEF1 | CMBL | 0.776805 | 5 | 0 | 5 |
| ARHGEF1 | XRCC2 | 0.763606 | 5 | 0 | 5 |
| ARHGEF1 | FUT8-AS1 | 0.76204 | 4 | 0 | 4 |
| ARHGEF1 | PGF | 0.738585 | 8 | 0 | 8 |
| ARHGEF1 | CCDC142 | 0.73693 | 3 | 0 | 3 |
| ARHGEF1 | ZNF611 | 0.726313 | 5 | 0 | 5 |
| ARHGEF1 | WDPCP | 0.719323 | 6 | 0 | 5 |
| ARHGEF1 | MFSD10 | 0.715862 | 3 | 0 | 3 |
| ARHGEF1 | KIFC2 | 0.709865 | 4 | 0 | 3 |
| ARHGEF1 | SOX12 | 0.709711 | 3 | 0 | 3 |
| ARHGEF1 | TNRC6C-AS1 | 0.708878 | 5 | 0 | 5 |
| ARHGEF1 | RAMP2-AS1 | 0.708404 | 4 | 0 | 4 |
| ARHGEF1 | SPDYE2 | 0.706146 | 4 | 0 | 4 |
| ARHGEF1 | WFDC6 | 0.705185 | 3 | 0 | 3 |
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