| Full name: ATP binding cassette subfamily B member 4 | Alias Symbol: MDR2|PFIC-3|GBD1 | ||
| Type: protein-coding gene | Cytoband: 7q21.12 | ||
| Entrez ID: 5244 | HGNC ID: HGNC:45 | Ensembl Gene: ENSG00000005471 | OMIM ID: 171060 |
| Drug and gene relationship at DGIdb | |||
ABCB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of ABCB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCB4 | 5244 | 207819_s_at | -0.2416 | 0.6786 | |
| GSE20347 | ABCB4 | 5244 | 207819_s_at | -0.0695 | 0.3531 | |
| GSE23400 | ABCB4 | 5244 | 207819_s_at | -0.1600 | 0.0000 | |
| GSE26886 | ABCB4 | 5244 | 207819_s_at | 0.2051 | 0.3149 | |
| GSE29001 | ABCB4 | 5244 | 207819_s_at | -0.2173 | 0.0922 | |
| GSE38129 | ABCB4 | 5244 | 207819_s_at | -0.1754 | 0.1205 | |
| GSE45670 | ABCB4 | 5244 | 207819_s_at | -0.4372 | 0.0002 | |
| GSE53622 | ABCB4 | 5244 | 99361 | -0.3730 | 0.0334 | |
| GSE53624 | ABCB4 | 5244 | 99361 | -0.3010 | 0.0019 | |
| GSE63941 | ABCB4 | 5244 | 207819_s_at | -1.1493 | 0.0003 | |
| GSE77861 | ABCB4 | 5244 | 207819_s_at | -0.2180 | 0.0266 | |
| GSE97050 | ABCB4 | 5244 | A_33_P3336760 | 0.0538 | 0.8204 | |
| SRP064894 | ABCB4 | 5244 | RNAseq | 0.1947 | 0.4556 | |
| SRP133303 | ABCB4 | 5244 | RNAseq | -0.7823 | 0.0015 | |
| SRP159526 | ABCB4 | 5244 | RNAseq | 0.1381 | 0.8231 | |
| SRP193095 | ABCB4 | 5244 | RNAseq | -0.0979 | 0.6732 | |
| SRP219564 | ABCB4 | 5244 | RNAseq | 0.1975 | 0.8141 | |
| TCGA | ABCB4 | 5244 | RNAseq | -0.2418 | 0.5426 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ABCB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCB4 | 5244 | 13 | 1 | 16 | |
| GSE20123 | ABCB4 | 5244 | 13 | 1 | 16 | |
| GSE43470 | ABCB4 | 5244 | 5 | 1 | 37 | |
| GSE46452 | ABCB4 | 5244 | 12 | 0 | 47 | |
| GSE47630 | ABCB4 | 5244 | 8 | 2 | 30 | |
| GSE54993 | ABCB4 | 5244 | 2 | 7 | 61 | |
| GSE54994 | ABCB4 | 5244 | 17 | 2 | 34 | |
| GSE60625 | ABCB4 | 5244 | 0 | 0 | 11 | |
| GSE74703 | ABCB4 | 5244 | 4 | 1 | 31 | |
| GSE74704 | ABCB4 | 5244 | 9 | 1 | 10 | |
| TCGA | ABCB4 | 5244 | 54 | 4 | 38 |
Total number of gains: 137; Total number of losses: 20; Total Number of normals: 331.
Somatic mutations of ABCB4:
Generating mutation plots.
Highly correlated genes for ABCB4:
Showing top 20/552 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCB4 | ZEB2 | 0.775414 | 3 | 0 | 3 |
| ABCB4 | TMEM178A | 0.769402 | 3 | 0 | 3 |
| ABCB4 | IRX1 | 0.733692 | 3 | 0 | 3 |
| ABCB4 | ITGBL1 | 0.729774 | 3 | 0 | 3 |
| ABCB4 | VASN | 0.721745 | 3 | 0 | 3 |
| ABCB4 | NEGR1 | 0.716378 | 3 | 0 | 3 |
| ABCB4 | MIR100HG | 0.707505 | 3 | 0 | 3 |
| ABCB4 | RSPO3 | 0.707233 | 4 | 0 | 4 |
| ABCB4 | NUDT2 | 0.70581 | 3 | 0 | 3 |
| ABCB4 | NEXN | 0.697079 | 3 | 0 | 3 |
| ABCB4 | CYP4V2 | 0.692351 | 4 | 0 | 4 |
| ABCB4 | MYOCD | 0.690116 | 3 | 0 | 3 |
| ABCB4 | GALNT15 | 0.688027 | 3 | 0 | 3 |
| ABCB4 | INMT | 0.684158 | 3 | 0 | 3 |
| ABCB4 | FCRL4 | 0.679697 | 4 | 0 | 4 |
| ABCB4 | RERG | 0.674924 | 4 | 0 | 4 |
| ABCB4 | TMEM234 | 0.673292 | 3 | 0 | 3 |
| ABCB4 | MAGI2-AS3 | 0.671291 | 4 | 0 | 3 |
| ABCB4 | WDFY3-AS2 | 0.665355 | 3 | 0 | 3 |
| ABCB4 | FCRLA | 0.665191 | 4 | 0 | 3 |
For details and further investigation, click here
