| Full name: iroquois homeobox 1 | Alias Symbol: IRX-5 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 79192 | HGNC ID: HGNC:14358 | Ensembl Gene: ENSG00000170549 | OMIM ID: 606197 |
| Drug and gene relationship at DGIdb | |||
Expression of IRX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRX1 | 79192 | 230472_at | -0.7891 | 0.3093 | |
| GSE26886 | IRX1 | 79192 | 230472_at | 1.1277 | 0.0855 | |
| GSE45670 | IRX1 | 79192 | 230472_at | -0.5495 | 0.3507 | |
| GSE53622 | IRX1 | 79192 | 66970 | 0.4451 | 0.0036 | |
| GSE53624 | IRX1 | 79192 | 66970 | 0.1228 | 0.1401 | |
| GSE63941 | IRX1 | 79192 | 230472_at | 1.8769 | 0.3545 | |
| GSE77861 | IRX1 | 79192 | 230472_at | -0.1293 | 0.1579 | |
| SRP133303 | IRX1 | 79192 | RNAseq | -2.2592 | 0.0009 | |
| TCGA | IRX1 | 79192 | RNAseq | 1.8057 | 0.0394 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by IRX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRX1 | 79192 | 13 | 0 | 17 | |
| GSE20123 | IRX1 | 79192 | 13 | 0 | 17 | |
| GSE43470 | IRX1 | 79192 | 16 | 1 | 26 | |
| GSE46452 | IRX1 | 79192 | 6 | 22 | 31 | |
| GSE47630 | IRX1 | 79192 | 6 | 11 | 23 | |
| GSE54993 | IRX1 | 79192 | 5 | 5 | 60 | |
| GSE54994 | IRX1 | 79192 | 29 | 1 | 23 | |
| GSE60625 | IRX1 | 79192 | 0 | 0 | 11 | |
| GSE74703 | IRX1 | 79192 | 13 | 0 | 23 | |
| GSE74704 | IRX1 | 79192 | 11 | 0 | 9 | |
| TCGA | IRX1 | 79192 | 58 | 4 | 34 |
Total number of gains: 170; Total number of losses: 44; Total Number of normals: 274.
Somatic mutations of IRX1:
Generating mutation plots.
Highly correlated genes for IRX1:
Showing top 20/32 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRX1 | ABCB4 | 0.733692 | 3 | 0 | 3 |
| IRX1 | LIMD1-AS1 | 0.683402 | 3 | 0 | 3 |
| IRX1 | CACHD1 | 0.679662 | 3 | 0 | 3 |
| IRX1 | TLE2 | 0.665749 | 4 | 0 | 3 |
| IRX1 | EMX2 | 0.658202 | 3 | 0 | 3 |
| IRX1 | OCA2 | 0.637056 | 3 | 0 | 3 |
| IRX1 | SLC14A1 | 0.636265 | 3 | 0 | 3 |
| IRX1 | BEND5 | 0.633578 | 3 | 0 | 3 |
| IRX1 | CALN1 | 0.626556 | 3 | 0 | 3 |
| IRX1 | ABCA3 | 0.622956 | 4 | 0 | 3 |
| IRX1 | CACNA1A | 0.619012 | 3 | 0 | 3 |
| IRX1 | FAM163A | 0.611626 | 3 | 0 | 3 |
| IRX1 | NTF3 | 0.60464 | 3 | 0 | 3 |
| IRX1 | SCN5A | 0.602157 | 5 | 0 | 4 |
| IRX1 | FMN2 | 0.59926 | 3 | 0 | 3 |
| IRX1 | P2RX1 | 0.587533 | 3 | 0 | 3 |
| IRX1 | GPRC5B | 0.583658 | 4 | 0 | 3 |
| IRX1 | OLFM1 | 0.575965 | 4 | 0 | 3 |
| IRX1 | NPPA | 0.575371 | 3 | 0 | 3 |
| IRX1 | KANK3 | 0.572505 | 4 | 0 | 3 |
For details and further investigation, click here
