| Full name: R-spondin 3 | Alias Symbol: FLJ14440 | ||
| Type: protein-coding gene | Cytoband: 6q22.33 | ||
| Entrez ID: 84870 | HGNC ID: HGNC:20866 | Ensembl Gene: ENSG00000146374 | OMIM ID: 610574 |
| Drug and gene relationship at DGIdb | |||
Expression of RSPO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RSPO3 | 84870 | 228186_s_at | -1.7214 | 0.2230 | |
| GSE26886 | RSPO3 | 84870 | 228186_s_at | 1.6104 | 0.0070 | |
| GSE45670 | RSPO3 | 84870 | 228186_s_at | -2.7897 | 0.0000 | |
| GSE53622 | RSPO3 | 84870 | 9245 | -0.8830 | 0.0000 | |
| GSE53624 | RSPO3 | 84870 | 9245 | -0.3821 | 0.0239 | |
| GSE63941 | RSPO3 | 84870 | 228186_s_at | -5.8980 | 0.0000 | |
| GSE77861 | RSPO3 | 84870 | 228186_s_at | 0.0549 | 0.6984 | |
| GSE97050 | RSPO3 | 84870 | A_24_P106542 | -0.2430 | 0.3533 | |
| SRP007169 | RSPO3 | 84870 | RNAseq | 4.9405 | 0.0003 | |
| SRP064894 | RSPO3 | 84870 | RNAseq | 0.3918 | 0.3721 | |
| SRP133303 | RSPO3 | 84870 | RNAseq | -0.4097 | 0.4506 | |
| SRP159526 | RSPO3 | 84870 | RNAseq | 0.7361 | 0.1937 | |
| SRP219564 | RSPO3 | 84870 | RNAseq | 1.2500 | 0.2591 | |
| TCGA | RSPO3 | 84870 | RNAseq | -0.7199 | 0.0077 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by RSPO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RSPO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RSPO3 | 84870 | 1 | 4 | 25 | |
| GSE20123 | RSPO3 | 84870 | 2 | 3 | 25 | |
| GSE43470 | RSPO3 | 84870 | 5 | 0 | 38 | |
| GSE46452 | RSPO3 | 84870 | 2 | 11 | 46 | |
| GSE47630 | RSPO3 | 84870 | 9 | 4 | 27 | |
| GSE54993 | RSPO3 | 84870 | 3 | 3 | 64 | |
| GSE54994 | RSPO3 | 84870 | 9 | 7 | 37 | |
| GSE60625 | RSPO3 | 84870 | 0 | 1 | 10 | |
| GSE74703 | RSPO3 | 84870 | 4 | 0 | 32 | |
| GSE74704 | RSPO3 | 84870 | 0 | 1 | 19 | |
| TCGA | RSPO3 | 84870 | 10 | 18 | 68 |
Total number of gains: 45; Total number of losses: 52; Total Number of normals: 391.
Somatic mutations of RSPO3:
Generating mutation plots.
Highly correlated genes for RSPO3:
Showing top 20/1121 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RSPO3 | AFF3 | 0.880866 | 3 | 0 | 3 |
| RSPO3 | FIBIN | 0.868052 | 4 | 0 | 4 |
| RSPO3 | LINC01279 | 0.818374 | 4 | 0 | 4 |
| RSPO3 | KCNT2 | 0.814337 | 7 | 0 | 7 |
| RSPO3 | DIXDC1 | 0.808196 | 6 | 0 | 6 |
| RSPO3 | MIR100HG | 0.806543 | 6 | 0 | 6 |
| RSPO3 | ARHGAP6 | 0.804618 | 6 | 0 | 6 |
| RSPO3 | BHMT2 | 0.799778 | 6 | 0 | 6 |
| RSPO3 | MEOX2 | 0.79748 | 5 | 0 | 5 |
| RSPO3 | PEG3 | 0.794206 | 4 | 0 | 4 |
| RSPO3 | FAM13C | 0.792608 | 4 | 0 | 4 |
| RSPO3 | C11orf96 | 0.791011 | 5 | 0 | 5 |
| RSPO3 | PLN | 0.784078 | 9 | 0 | 9 |
| RSPO3 | DTNA | 0.78116 | 4 | 0 | 4 |
| RSPO3 | MAGI2-AS3 | 0.778727 | 6 | 0 | 6 |
| RSPO3 | PDE1A | 0.778187 | 8 | 0 | 7 |
| RSPO3 | SMPD1 | 0.776911 | 3 | 0 | 3 |
| RSPO3 | EDNRB | 0.774864 | 6 | 0 | 6 |
| RSPO3 | ADAMTS5 | 0.771534 | 7 | 0 | 6 |
| RSPO3 | MSRB3 | 0.769992 | 7 | 0 | 7 |
For details and further investigation, click here
