| Full name: zinc finger E-box binding homeobox 2 | Alias Symbol: KIAA0569|SIP-1|SIP1 | ||
| Type: protein-coding gene | Cytoband: 2q22.3 | ||
| Entrez ID: 9839 | HGNC ID: HGNC:14881 | Ensembl Gene: ENSG00000169554 | OMIM ID: 605802 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ZEB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZEB2 | 9839 | 228333_at | -0.7509 | 0.2950 | |
| GSE20347 | ZEB2 | 9839 | 203603_s_at | 0.0594 | 0.8580 | |
| GSE23400 | ZEB2 | 9839 | 203603_s_at | -0.1129 | 0.2562 | |
| GSE26886 | ZEB2 | 9839 | 228333_at | -0.0879 | 0.8062 | |
| GSE29001 | ZEB2 | 9839 | 203603_s_at | 0.4957 | 0.2893 | |
| GSE38129 | ZEB2 | 9839 | 203603_s_at | -0.4962 | 0.2274 | |
| GSE45670 | ZEB2 | 9839 | 203603_s_at | -1.9392 | 0.0004 | |
| GSE53622 | ZEB2 | 9839 | 236 | -1.1357 | 0.0000 | |
| GSE53624 | ZEB2 | 9839 | 236 | -0.9537 | 0.0000 | |
| GSE63941 | ZEB2 | 9839 | 203603_s_at | -6.2303 | 0.0000 | |
| GSE77861 | ZEB2 | 9839 | 233031_at | 0.0580 | 0.5467 | |
| GSE97050 | ZEB2 | 9839 | A_33_P3243832 | -0.2688 | 0.2852 | |
| SRP007169 | ZEB2 | 9839 | RNAseq | 2.4139 | 0.0000 | |
| SRP008496 | ZEB2 | 9839 | RNAseq | 3.1300 | 0.0000 | |
| SRP064894 | ZEB2 | 9839 | RNAseq | 0.1257 | 0.7104 | |
| SRP133303 | ZEB2 | 9839 | RNAseq | -0.4751 | 0.0367 | |
| SRP159526 | ZEB2 | 9839 | RNAseq | -0.5429 | 0.2953 | |
| SRP193095 | ZEB2 | 9839 | RNAseq | 0.8221 | 0.0014 | |
| SRP219564 | ZEB2 | 9839 | RNAseq | -0.1306 | 0.7475 | |
| TCGA | ZEB2 | 9839 | RNAseq | -0.3417 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by ZEB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZEB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZEB2 | 9839 | 4 | 3 | 23 | |
| GSE20123 | ZEB2 | 9839 | 3 | 3 | 24 | |
| GSE43470 | ZEB2 | 9839 | 3 | 1 | 39 | |
| GSE46452 | ZEB2 | 9839 | 1 | 4 | 54 | |
| GSE47630 | ZEB2 | 9839 | 5 | 3 | 32 | |
| GSE54993 | ZEB2 | 9839 | 0 | 5 | 65 | |
| GSE54994 | ZEB2 | 9839 | 10 | 2 | 41 | |
| GSE60625 | ZEB2 | 9839 | 0 | 3 | 8 | |
| GSE74703 | ZEB2 | 9839 | 2 | 1 | 33 | |
| GSE74704 | ZEB2 | 9839 | 3 | 1 | 16 | |
| TCGA | ZEB2 | 9839 | 22 | 11 | 63 |
Total number of gains: 53; Total number of losses: 37; Total Number of normals: 398.
Somatic mutations of ZEB2:
Generating mutation plots.
Highly correlated genes for ZEB2:
Showing top 20/1131 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZEB2 | CLEC3B | 0.829393 | 3 | 0 | 3 |
| ZEB2 | CNRIP1 | 0.82676 | 8 | 0 | 8 |
| ZEB2 | ZNF583 | 0.822365 | 3 | 0 | 3 |
| ZEB2 | CYP21A2 | 0.820904 | 3 | 0 | 3 |
| ZEB2 | NLGN4Y | 0.815437 | 3 | 0 | 3 |
| ZEB2 | SH3RF3 | 0.806784 | 3 | 0 | 3 |
| ZEB2 | PGM5-AS1 | 0.801646 | 3 | 0 | 3 |
| ZEB2 | BICC1 | 0.798543 | 7 | 0 | 7 |
| ZEB2 | FIBIN | 0.797948 | 5 | 0 | 5 |
| ZEB2 | DIXDC1 | 0.793167 | 9 | 0 | 9 |
| ZEB2 | LINC01279 | 0.790663 | 4 | 0 | 4 |
| ZEB2 | LINC01082 | 0.789269 | 5 | 0 | 5 |
| ZEB2 | NKAPL | 0.775443 | 4 | 0 | 4 |
| ZEB2 | ABCB4 | 0.775414 | 3 | 0 | 3 |
| ZEB2 | MRVI1 | 0.775195 | 7 | 0 | 6 |
| ZEB2 | SMPD1 | 0.774823 | 4 | 0 | 4 |
| ZEB2 | CCDC80 | 0.773854 | 7 | 0 | 7 |
| ZEB2 | MIR100HG | 0.763129 | 6 | 0 | 6 |
| ZEB2 | CCL14 | 0.760867 | 3 | 0 | 3 |
| ZEB2 | SCUBE3 | 0.760258 | 3 | 0 | 3 |
For details and further investigation, click here
