| Full name: nexilin F-actin binding protein | Alias Symbol: nexilin|NELIN | ||
| Type: protein-coding gene | Cytoband: 1p31.1 | ||
| Entrez ID: 91624 | HGNC ID: HGNC:29557 | Ensembl Gene: ENSG00000162614 | OMIM ID: 613121 |
| Drug and gene relationship at DGIdb | |||
Expression of NEXN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEXN | 91624 | 1552309_a_at | -2.3686 | 0.0939 | |
| GSE26886 | NEXN | 91624 | 1552309_a_at | 0.5362 | 0.2316 | |
| GSE45670 | NEXN | 91624 | 1552309_a_at | -3.0649 | 0.0000 | |
| GSE53622 | NEXN | 91624 | 41702 | -1.4994 | 0.0000 | |
| GSE53624 | NEXN | 91624 | 41702 | -1.3688 | 0.0000 | |
| GSE63941 | NEXN | 91624 | 226103_at | -6.4022 | 0.0000 | |
| GSE77861 | NEXN | 91624 | 1552309_a_at | 0.0577 | 0.7314 | |
| GSE97050 | NEXN | 91624 | A_23_P200001 | -1.1187 | 0.1583 | |
| SRP007169 | NEXN | 91624 | RNAseq | 5.2839 | 0.0001 | |
| SRP064894 | NEXN | 91624 | RNAseq | -0.4743 | 0.2471 | |
| SRP133303 | NEXN | 91624 | RNAseq | -1.2169 | 0.0002 | |
| SRP159526 | NEXN | 91624 | RNAseq | -1.0777 | 0.0674 | |
| SRP193095 | NEXN | 91624 | RNAseq | 0.6339 | 0.0029 | |
| SRP219564 | NEXN | 91624 | RNAseq | -1.1086 | 0.2586 | |
| TCGA | NEXN | 91624 | RNAseq | -0.6634 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by NEXN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEXN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEXN | 91624 | 0 | 7 | 23 | |
| GSE20123 | NEXN | 91624 | 0 | 7 | 23 | |
| GSE43470 | NEXN | 91624 | 4 | 4 | 35 | |
| GSE46452 | NEXN | 91624 | 0 | 1 | 58 | |
| GSE47630 | NEXN | 91624 | 8 | 6 | 26 | |
| GSE54993 | NEXN | 91624 | 0 | 0 | 70 | |
| GSE54994 | NEXN | 91624 | 6 | 3 | 44 | |
| GSE60625 | NEXN | 91624 | 0 | 0 | 11 | |
| GSE74703 | NEXN | 91624 | 3 | 3 | 30 | |
| GSE74704 | NEXN | 91624 | 0 | 4 | 16 | |
| TCGA | NEXN | 91624 | 7 | 25 | 64 |
Total number of gains: 28; Total number of losses: 60; Total Number of normals: 400.
Somatic mutations of NEXN:
Generating mutation plots.
Highly correlated genes for NEXN:
Showing top 20/1109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEXN | NEGR1 | 0.887324 | 6 | 0 | 6 |
| NEXN | ARHGAP6 | 0.880515 | 6 | 0 | 6 |
| NEXN | PLA2G5 | 0.874254 | 4 | 0 | 4 |
| NEXN | MRVI1 | 0.867516 | 8 | 0 | 8 |
| NEXN | MSRB3 | 0.86146 | 7 | 0 | 7 |
| NEXN | PGM5 | 0.850879 | 6 | 0 | 6 |
| NEXN | AFF3 | 0.849911 | 3 | 0 | 3 |
| NEXN | ACTG2 | 0.847914 | 9 | 0 | 9 |
| NEXN | LMOD1 | 0.839251 | 9 | 0 | 9 |
| NEXN | FXYD1 | 0.838626 | 3 | 0 | 3 |
| NEXN | ITGA9 | 0.831365 | 6 | 0 | 6 |
| NEXN | ASPA | 0.829853 | 6 | 0 | 6 |
| NEXN | MIR100HG | 0.829586 | 7 | 0 | 7 |
| NEXN | CNN1 | 0.825033 | 7 | 0 | 7 |
| NEXN | BHMT2 | 0.824613 | 7 | 0 | 6 |
| NEXN | FILIP1 | 0.8245 | 5 | 0 | 5 |
| NEXN | ACTA2 | 0.822996 | 9 | 0 | 9 |
| NEXN | PRUNE2 | 0.822629 | 9 | 0 | 9 |
| NEXN | XKR4 | 0.822226 | 5 | 0 | 5 |
| NEXN | UBXN10 | 0.820734 | 3 | 0 | 3 |
For details and further investigation, click here
