| Full name: angiotensin I converting enzyme | Alias Symbol: ACE1|CD143 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 1636 | HGNC ID: HGNC:2707 | Ensembl Gene: ENSG00000159640 | OMIM ID: 106180 |
| Drug and gene relationship at DGIdb | |||
ACE involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05142 | Chagas disease (American trypanosomiasis) |
Expression of ACE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACE | 1636 | 227463_at | 0.2507 | 0.5553 | |
| GSE20347 | ACE | 1636 | 209749_s_at | -0.0723 | 0.2141 | |
| GSE23400 | ACE | 1636 | 209749_s_at | -0.0885 | 0.0018 | |
| GSE26886 | ACE | 1636 | 227463_at | 0.2644 | 0.0593 | |
| GSE29001 | ACE | 1636 | 209749_s_at | -0.1270 | 0.2260 | |
| GSE38129 | ACE | 1636 | 209749_s_at | -0.1067 | 0.0755 | |
| GSE45670 | ACE | 1636 | 227463_at | -0.4261 | 0.0270 | |
| GSE53622 | ACE | 1636 | 59221 | 0.2439 | 0.0002 | |
| GSE53624 | ACE | 1636 | 59221 | -0.0627 | 0.6216 | |
| GSE63941 | ACE | 1636 | 227463_at | -0.6540 | 0.0744 | |
| GSE77861 | ACE | 1636 | 227463_at | -0.1037 | 0.5293 | |
| GSE97050 | ACE | 1636 | A_33_P3229288 | 0.1588 | 0.5707 | |
| SRP007169 | ACE | 1636 | RNAseq | 1.2020 | 0.0731 | |
| SRP064894 | ACE | 1636 | RNAseq | 0.1088 | 0.7036 | |
| SRP133303 | ACE | 1636 | RNAseq | 0.0430 | 0.8434 | |
| SRP159526 | ACE | 1636 | RNAseq | 0.0669 | 0.8635 | |
| SRP193095 | ACE | 1636 | RNAseq | -0.2170 | 0.4965 | |
| SRP219564 | ACE | 1636 | RNAseq | 0.9015 | 0.0085 | |
| TCGA | ACE | 1636 | RNAseq | -0.3029 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACE | 1636 | 3 | 1 | 26 | |
| GSE20123 | ACE | 1636 | 3 | 1 | 26 | |
| GSE43470 | ACE | 1636 | 4 | 0 | 39 | |
| GSE46452 | ACE | 1636 | 31 | 0 | 28 | |
| GSE47630 | ACE | 1636 | 7 | 1 | 32 | |
| GSE54993 | ACE | 1636 | 2 | 5 | 63 | |
| GSE54994 | ACE | 1636 | 9 | 5 | 39 | |
| GSE60625 | ACE | 1636 | 4 | 0 | 7 | |
| GSE74703 | ACE | 1636 | 4 | 0 | 32 | |
| GSE74704 | ACE | 1636 | 3 | 1 | 16 | |
| TCGA | ACE | 1636 | 31 | 8 | 57 |
Total number of gains: 101; Total number of losses: 22; Total Number of normals: 365.
Somatic mutations of ACE:
Generating mutation plots.
Highly correlated genes for ACE:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACE | KCTD19 | 0.766185 | 3 | 0 | 3 |
| ACE | LCE1D | 0.744694 | 3 | 0 | 3 |
| ACE | OR4D6 | 0.737826 | 3 | 0 | 3 |
| ACE | STRC | 0.731602 | 3 | 0 | 3 |
| ACE | SPACA3 | 0.725519 | 5 | 0 | 5 |
| ACE | FAM181A | 0.715591 | 3 | 0 | 3 |
| ACE | ZNF843 | 0.712964 | 3 | 0 | 3 |
| ACE | CD248 | 0.705732 | 4 | 0 | 4 |
| ACE | KIF17 | 0.693388 | 3 | 0 | 3 |
| ACE | RASL10B | 0.687379 | 4 | 0 | 3 |
| ACE | ABTB1 | 0.68623 | 3 | 0 | 3 |
| ACE | GPR152 | 0.686034 | 3 | 0 | 3 |
| ACE | SYT3 | 0.685085 | 3 | 0 | 3 |
| ACE | MAGEE1 | 0.683104 | 4 | 0 | 4 |
| ACE | RHBDD3 | 0.682061 | 4 | 0 | 4 |
| ACE | LDB2 | 0.68193 | 4 | 0 | 3 |
| ACE | SLC22A31 | 0.674332 | 5 | 0 | 5 |
| ACE | PHF21A | 0.674326 | 3 | 0 | 3 |
| ACE | GNL1 | 0.671055 | 3 | 0 | 3 |
| ACE | CSH2 | 0.670236 | 3 | 0 | 3 |
For details and further investigation, click here
