| Full name: chorionic somatomammotropin hormone 2 | Alias Symbol: hCS-B|CSB|CS-2 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 1443 | HGNC ID: HGNC:2441 | Ensembl Gene: ENSG00000213218 | OMIM ID: 118820 |
| Drug and gene relationship at DGIdb | |||
CSH2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of CSH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CSH2 | 1443 | 84535 | 0.1546 | 0.0561 | |
| GSE53624 | CSH2 | 1443 | 84535 | 0.4406 | 0.0005 | |
| GSE97050 | CSH2 | 1443 | A_23_P207154 | -0.0080 | 0.9774 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CSH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSH2 | 1443 | 3 | 1 | 26 | |
| GSE20123 | CSH2 | 1443 | 3 | 1 | 26 | |
| GSE43470 | CSH2 | 1443 | 4 | 0 | 39 | |
| GSE46452 | CSH2 | 1443 | 31 | 0 | 28 | |
| GSE47630 | CSH2 | 1443 | 7 | 1 | 32 | |
| GSE54993 | CSH2 | 1443 | 2 | 5 | 63 | |
| GSE54994 | CSH2 | 1443 | 9 | 4 | 40 | |
| GSE60625 | CSH2 | 1443 | 4 | 0 | 7 | |
| GSE74703 | CSH2 | 1443 | 4 | 0 | 32 | |
| GSE74704 | CSH2 | 1443 | 3 | 1 | 16 | |
| TCGA | CSH2 | 1443 | 30 | 8 | 58 |
Total number of gains: 100; Total number of losses: 21; Total Number of normals: 367.
Somatic mutations of CSH2:
Generating mutation plots.
Highly correlated genes for CSH2:
Showing top 20/52 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSH2 | RGR | 0.799507 | 3 | 0 | 3 |
| CSH2 | C19orf44 | 0.783037 | 3 | 0 | 3 |
| CSH2 | SPEF1 | 0.769922 | 3 | 0 | 3 |
| CSH2 | SLC39A5 | 0.759933 | 3 | 0 | 3 |
| CSH2 | ALPP | 0.755172 | 3 | 0 | 3 |
| CSH2 | SLC4A1 | 0.727154 | 3 | 0 | 3 |
| CSH2 | SPACA3 | 0.725992 | 3 | 0 | 3 |
| CSH2 | GCM2 | 0.723466 | 3 | 0 | 3 |
| CSH2 | CSHL1 | 0.72155 | 3 | 0 | 3 |
| CSH2 | STRC | 0.720455 | 3 | 0 | 3 |
| CSH2 | CLTCL1 | 0.719339 | 3 | 0 | 3 |
| CSH2 | ANKDD1A | 0.719145 | 3 | 0 | 3 |
| CSH2 | CDH22 | 0.711776 | 3 | 0 | 3 |
| CSH2 | LHX9 | 0.710314 | 3 | 0 | 3 |
| CSH2 | GH1 | 0.708553 | 3 | 0 | 3 |
| CSH2 | PLA2G2F | 0.704541 | 3 | 0 | 3 |
| CSH2 | KLHDC4 | 0.704031 | 3 | 0 | 3 |
| CSH2 | IL1F10 | 0.701179 | 3 | 0 | 3 |
| CSH2 | CCL25 | 0.696594 | 3 | 0 | 3 |
| CSH2 | SYCN | 0.690571 | 3 | 0 | 3 |
For details and further investigation, click here
