| Full name: actin alpha 1, skeletal muscle | Alias Symbol: NEM3 | ||
| Type: protein-coding gene | Cytoband: 1q42.13 | ||
| Entrez ID: 58 | HGNC ID: HGNC:129 | Ensembl Gene: ENSG00000143632 | OMIM ID: 102610 |
| Drug and gene relationship at DGIdb | |||
Expression of ACTA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTA1 | 58 | 203872_at | -0.7418 | 0.4649 | |
| GSE20347 | ACTA1 | 58 | 203872_at | -0.1368 | 0.0520 | |
| GSE23400 | ACTA1 | 58 | 203872_at | -0.0598 | 0.6547 | |
| GSE26886 | ACTA1 | 58 | 203872_at | 0.3312 | 0.0043 | |
| GSE29001 | ACTA1 | 58 | 203872_at | -0.1084 | 0.3592 | |
| GSE38129 | ACTA1 | 58 | 203872_at | -0.2836 | 0.0001 | |
| GSE45670 | ACTA1 | 58 | 203872_at | -0.2047 | 0.0715 | |
| GSE53622 | ACTA1 | 58 | 83365 | -0.6744 | 0.0042 | |
| GSE53624 | ACTA1 | 58 | 83365 | -1.0870 | 0.0000 | |
| GSE63941 | ACTA1 | 58 | 203872_at | 0.2580 | 0.1673 | |
| GSE77861 | ACTA1 | 58 | 203872_at | 0.0164 | 0.9278 | |
| GSE97050 | ACTA1 | 58 | A_23_P1102 | -1.6159 | 0.1726 | |
| TCGA | ACTA1 | 58 | RNAseq | 0.4742 | 0.4248 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACTA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACTA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTA1 | 58 | 11 | 0 | 19 | |
| GSE20123 | ACTA1 | 58 | 11 | 0 | 19 | |
| GSE43470 | ACTA1 | 58 | 8 | 1 | 34 | |
| GSE46452 | ACTA1 | 58 | 4 | 2 | 53 | |
| GSE47630 | ACTA1 | 58 | 15 | 0 | 25 | |
| GSE54993 | ACTA1 | 58 | 0 | 6 | 64 | |
| GSE54994 | ACTA1 | 58 | 17 | 0 | 36 | |
| GSE60625 | ACTA1 | 58 | 0 | 0 | 11 | |
| GSE74703 | ACTA1 | 58 | 8 | 1 | 27 | |
| GSE74704 | ACTA1 | 58 | 5 | 0 | 15 | |
| TCGA | ACTA1 | 58 | 45 | 2 | 49 |
Total number of gains: 124; Total number of losses: 12; Total Number of normals: 352.
Somatic mutations of ACTA1:
Generating mutation plots.
Highly correlated genes for ACTA1:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTA1 | CSRP3 | 0.789475 | 3 | 0 | 3 |
| ACTA1 | BOLA3-AS1 | 0.675217 | 3 | 0 | 3 |
| ACTA1 | SLN | 0.653949 | 5 | 0 | 4 |
| ACTA1 | HMX1 | 0.639556 | 3 | 0 | 3 |
| ACTA1 | SCGB1D2 | 0.637609 | 3 | 0 | 3 |
| ACTA1 | CACNA1H | 0.630051 | 5 | 0 | 4 |
| ACTA1 | TBC1D28 | 0.6184 | 3 | 0 | 3 |
| ACTA1 | NRSN2 | 0.617572 | 3 | 0 | 3 |
| ACTA1 | ABHD16B | 0.613654 | 3 | 0 | 3 |
| ACTA1 | CHST8 | 0.613314 | 4 | 0 | 3 |
| ACTA1 | CREB3L4 | 0.610749 | 3 | 0 | 3 |
| ACTA1 | CD1E | 0.594052 | 3 | 0 | 3 |
| ACTA1 | MEIS2 | 0.589744 | 3 | 0 | 3 |
| ACTA1 | SCGB3A1 | 0.588925 | 4 | 0 | 3 |
| ACTA1 | KCNQ2 | 0.588835 | 4 | 0 | 4 |
| ACTA1 | TNNC1 | 0.586973 | 5 | 0 | 3 |
| ACTA1 | ADAMTS10 | 0.586531 | 4 | 0 | 3 |
| ACTA1 | LCN1 | 0.579945 | 6 | 0 | 4 |
| ACTA1 | MYH3 | 0.572767 | 4 | 0 | 3 |
| ACTA1 | HDAC11 | 0.571113 | 3 | 0 | 3 |
For details and further investigation, click here
