| Full name: troponin C1, slow skeletal and cardiac type | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 7134 | HGNC ID: HGNC:11943 | Ensembl Gene: ENSG00000114854 | OMIM ID: 191040 |
| Drug and gene relationship at DGIdb | |||
TNNC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of TNNC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNC1 | 7134 | 209904_at | 0.1545 | 0.7105 | |
| GSE20347 | TNNC1 | 7134 | 209904_at | -0.0427 | 0.4516 | |
| GSE23400 | TNNC1 | 7134 | 209904_at | 0.0842 | 0.4475 | |
| GSE26886 | TNNC1 | 7134 | 209904_at | 0.0643 | 0.5191 | |
| GSE29001 | TNNC1 | 7134 | 209904_at | 0.0830 | 0.3466 | |
| GSE38129 | TNNC1 | 7134 | 209904_at | -0.1127 | 0.3678 | |
| GSE45670 | TNNC1 | 7134 | 209904_at | -0.0150 | 0.8827 | |
| GSE53622 | TNNC1 | 7134 | 19537 | -0.2300 | 0.0056 | |
| GSE53624 | TNNC1 | 7134 | 19537 | -0.2355 | 0.1001 | |
| GSE63941 | TNNC1 | 7134 | 209904_at | 0.9014 | 0.4439 | |
| GSE77861 | TNNC1 | 7134 | 209904_at | -0.1377 | 0.3710 | |
| GSE97050 | TNNC1 | 7134 | A_23_P166823 | -1.0018 | 0.2641 | |
| TCGA | TNNC1 | 7134 | RNAseq | -3.5127 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TNNC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNNC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNC1 | 7134 | 0 | 18 | 12 | |
| GSE20123 | TNNC1 | 7134 | 0 | 19 | 11 | |
| GSE43470 | TNNC1 | 7134 | 0 | 18 | 25 | |
| GSE46452 | TNNC1 | 7134 | 2 | 17 | 40 | |
| GSE47630 | TNNC1 | 7134 | 1 | 24 | 15 | |
| GSE54993 | TNNC1 | 7134 | 6 | 2 | 62 | |
| GSE54994 | TNNC1 | 7134 | 0 | 33 | 20 | |
| GSE60625 | TNNC1 | 7134 | 5 | 0 | 6 | |
| GSE74703 | TNNC1 | 7134 | 0 | 14 | 22 | |
| GSE74704 | TNNC1 | 7134 | 0 | 12 | 8 | |
| TCGA | TNNC1 | 7134 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of TNNC1:
Generating mutation plots.
Highly correlated genes for TNNC1:
Showing top 20/58 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNC1 | CA3 | 0.730738 | 4 | 0 | 3 |
| TNNC1 | VNN3 | 0.702258 | 3 | 0 | 3 |
| TNNC1 | SLC19A3 | 0.669203 | 4 | 0 | 3 |
| TNNC1 | ALPP | 0.664129 | 4 | 0 | 3 |
| TNNC1 | ACRBP | 0.663147 | 3 | 0 | 3 |
| TNNC1 | LINC00566 | 0.639428 | 3 | 0 | 3 |
| TNNC1 | FGF22 | 0.616551 | 3 | 0 | 3 |
| TNNC1 | KISS1 | 0.614332 | 3 | 0 | 3 |
| TNNC1 | TNNI1 | 0.613837 | 5 | 0 | 3 |
| TNNC1 | MYH2 | 0.613674 | 4 | 0 | 3 |
| TNNC1 | SLC22A6 | 0.60647 | 3 | 0 | 3 |
| TNNC1 | LINC00454 | 0.60476 | 3 | 0 | 3 |
| TNNC1 | SYNDIG1L | 0.603556 | 3 | 0 | 3 |
| TNNC1 | MYL2 | 0.598284 | 4 | 0 | 3 |
| TNNC1 | IL3RA | 0.596691 | 4 | 0 | 3 |
| TNNC1 | SNX8 | 0.595751 | 4 | 0 | 3 |
| TNNC1 | TELO2 | 0.595553 | 5 | 0 | 5 |
| TNNC1 | PSPN | 0.595057 | 4 | 0 | 4 |
| TNNC1 | SSTR3 | 0.592934 | 3 | 0 | 3 |
| TNNC1 | UFSP1 | 0.588472 | 3 | 0 | 3 |
For details and further investigation, click here
