| Full name: H6 family homeobox 1 | Alias Symbol: H6|NKX5-3 | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 3166 | HGNC ID: HGNC:5017 | Ensembl Gene: ENSG00000215612 | OMIM ID: 142992 |
| Drug and gene relationship at DGIdb | |||
Expression of HMX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMX1 | 3166 | 207353_s_at | 0.1586 | 0.5735 | |
| GSE20347 | HMX1 | 3166 | 207353_s_at | -0.0221 | 0.8260 | |
| GSE23400 | HMX1 | 3166 | 207353_s_at | -0.0879 | 0.0431 | |
| GSE26886 | HMX1 | 3166 | 207353_s_at | 0.5475 | 0.0001 | |
| GSE38129 | HMX1 | 3166 | 207353_s_at | -0.1497 | 0.1883 | |
| GSE45670 | HMX1 | 3166 | 207353_s_at | -0.0141 | 0.9057 | |
| GSE53622 | HMX1 | 3166 | 30695 | 0.0310 | 0.7393 | |
| GSE53624 | HMX1 | 3166 | 30695 | -0.0304 | 0.7181 | |
| GSE63941 | HMX1 | 3166 | 207353_s_at | 0.8766 | 0.0012 | |
| GSE77861 | HMX1 | 3166 | 207353_s_at | 0.0396 | 0.8271 | |
| GSE97050 | HMX1 | 3166 | A_33_P3279009 | -0.1964 | 0.4690 | |
| SRP159526 | HMX1 | 3166 | RNAseq | 7.3359 | 0.0000 | |
| TCGA | HMX1 | 3166 | RNAseq | 3.1433 | 0.0007 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HMX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMX1 | 3166 | 0 | 18 | 12 | |
| GSE20123 | HMX1 | 3166 | 0 | 17 | 13 | |
| GSE43470 | HMX1 | 3166 | 0 | 17 | 26 | |
| GSE46452 | HMX1 | 3166 | 1 | 36 | 22 | |
| GSE47630 | HMX1 | 3166 | 1 | 19 | 20 | |
| GSE54993 | HMX1 | 3166 | 10 | 0 | 60 | |
| GSE54994 | HMX1 | 3166 | 3 | 14 | 36 | |
| GSE60625 | HMX1 | 3166 | 0 | 0 | 11 | |
| GSE74703 | HMX1 | 3166 | 0 | 13 | 23 | |
| GSE74704 | HMX1 | 3166 | 0 | 10 | 10 | |
| TCGA | HMX1 | 3166 | 8 | 48 | 40 |
Total number of gains: 23; Total number of losses: 192; Total Number of normals: 273.
Somatic mutations of HMX1:
Generating mutation plots.
Highly correlated genes for HMX1:
Showing top 20/703 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMX1 | PPP1R12C | 0.850927 | 3 | 0 | 3 |
| HMX1 | CACNA1H | 0.757764 | 3 | 0 | 3 |
| HMX1 | AMN | 0.743457 | 5 | 0 | 5 |
| HMX1 | RBBP8NL | 0.727605 | 3 | 0 | 3 |
| HMX1 | MAPRE3 | 0.726507 | 7 | 0 | 7 |
| HMX1 | CNIH2 | 0.725865 | 3 | 0 | 3 |
| HMX1 | FRS3 | 0.707114 | 3 | 0 | 3 |
| HMX1 | FBRSL1 | 0.697653 | 4 | 0 | 4 |
| HMX1 | CLDN19 | 0.689159 | 6 | 0 | 5 |
| HMX1 | RIMBP2 | 0.685928 | 3 | 0 | 3 |
| HMX1 | SLC25A53 | 0.683872 | 3 | 0 | 3 |
| HMX1 | CASKIN1 | 0.683434 | 4 | 0 | 4 |
| HMX1 | NPEPL1 | 0.683294 | 8 | 0 | 7 |
| HMX1 | LINC00598 | 0.68309 | 4 | 0 | 4 |
| HMX1 | SPTAN1 | 0.680967 | 3 | 0 | 3 |
| HMX1 | MUC3B | 0.678483 | 6 | 0 | 6 |
| HMX1 | GSDMD | 0.678277 | 3 | 0 | 3 |
| HMX1 | MLXIPL | 0.678218 | 8 | 0 | 7 |
| HMX1 | ZNF527 | 0.677203 | 4 | 0 | 4 |
| HMX1 | ARVCF | 0.676627 | 8 | 0 | 7 |
For details and further investigation, click here
